Advances in nanomedicine for the treatment of ankylosing spondylitis

Yanhai Xi,1,* Tingwang Jiang,2,* Birendra Chaurasiya,3 Yanyan Zhou,1 Jiangmin Yu,1 Jiankun Wen,1 Yan Shen,3 Xiaojian Ye,1 Thomas J Webster4 1Department of Spine Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, People’s Republic of China; 2Department of Immunology...

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Autores principales:	Xi Y, Jiang T, Chaurasiya B, Zhou Y, Yu J, Wen J, Shen Y, Ye X, Webster TJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	ankylosing spondylitis pathogenesis genetic factors environmental factors treatment approaches. Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/f8722d356e9043af9e21a346840c7ae9
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spelling	oai:doaj.org-article:f8722d356e9043af9e21a346840c7ae92021-12-02T04:51:18ZAdvances in nanomedicine for the treatment of ankylosing spondylitis1178-2013https://doaj.org/article/f8722d356e9043af9e21a346840c7ae92019-10-01T00:00:00Zhttps://www.dovepress.com/advances-in-nanomedicine-for-the-treatment-of-ankylosing-spondylitis-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Yanhai Xi,1,* Tingwang Jiang,2,* Birendra Chaurasiya,3 Yanyan Zhou,1 Jiangmin Yu,1 Jiankun Wen,1 Yan Shen,3 Xiaojian Ye,1 Thomas J Webster4 1Department of Spine Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, People’s Republic of China; 2Department of Immunology and Microbiology, Institution of Laboratory Medicine of Changshu, Changshu, Jiangsu 215500, People’s Republic of China; 3Department of Pharmaceutics, Center for Research Development and Evaluation of Pharmaceutical Excipients and Generic Drugs, China Pharmaceutical University, Nanjing, People’s Republic of China; 4Department of Chemical Engineering, Northeastern University, Boston, MA, USA*These authors contributed equally to this workCorrespondence: Xiaojian YeDepartment of Spine Surgery, Changzheng Hospital, Second Military Medical University, 360 Huntington Avenue, Shanghai, MA 200003, People’s Republic of ChinaTel +86 1 381 734 6934Email xjyespine@smmu.edu.cnThomas J WebsterDepartment of Chemical Engineering, Northeastern University, Boston, MA 02115, USATel +1 617 373 6585Email th.webster@neu.eduAbstract: Ankylosing spondylitis (AS) is a complex disease characterized by inflammation and ankylosis primarily at the cartilage–bone interface. The disease is more common in young males and risk factors include both genetic and environmental. While the pathogenesis of AS is not completely understood, it is thought to be an immune-mediated disease involving inflammatory cellular infiltrates, and human leukocyte antigen-B27. Currently, there is no specific diagnostic technique available for this disease; therefore conventional diagnostic approaches such as clinical symptoms, laboratory tests and imaging techniques are used. There are various review papers that have been published on conventional treatment approaches, and in this review work, we focus on the more promising nanomedicine-based treatment modalities to move this field forward.Keywords: ankylosing spondylitis, pathogenesis, genetic factors, environmental factors, treatment approachesXi YJiang TChaurasiya BZhou YYu JWen JShen YYe XWebster TJDove Medical Pressarticleankylosing spondylitispathogenesisgenetic factorsenvironmental factorstreatment approaches.Medicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 8521-8542 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	ankylosing spondylitis pathogenesis genetic factors environmental factors treatment approaches. Medicine (General) R5-920
spellingShingle	ankylosing spondylitis pathogenesis genetic factors environmental factors treatment approaches. Medicine (General) R5-920 Xi Y Jiang T Chaurasiya B Zhou Y Yu J Wen J Shen Y Ye X Webster TJ Advances in nanomedicine for the treatment of ankylosing spondylitis
description	Yanhai Xi,1,* Tingwang Jiang,2,* Birendra Chaurasiya,3 Yanyan Zhou,1 Jiangmin Yu,1 Jiankun Wen,1 Yan Shen,3 Xiaojian Ye,1 Thomas J Webster4 1Department of Spine Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, People’s Republic of China; 2Department of Immunology and Microbiology, Institution of Laboratory Medicine of Changshu, Changshu, Jiangsu 215500, People’s Republic of China; 3Department of Pharmaceutics, Center for Research Development and Evaluation of Pharmaceutical Excipients and Generic Drugs, China Pharmaceutical University, Nanjing, People’s Republic of China; 4Department of Chemical Engineering, Northeastern University, Boston, MA, USA*These authors contributed equally to this workCorrespondence: Xiaojian YeDepartment of Spine Surgery, Changzheng Hospital, Second Military Medical University, 360 Huntington Avenue, Shanghai, MA 200003, People’s Republic of ChinaTel +86 1 381 734 6934Email xjyespine@smmu.edu.cnThomas J WebsterDepartment of Chemical Engineering, Northeastern University, Boston, MA 02115, USATel +1 617 373 6585Email th.webster@neu.eduAbstract: Ankylosing spondylitis (AS) is a complex disease characterized by inflammation and ankylosis primarily at the cartilage–bone interface. The disease is more common in young males and risk factors include both genetic and environmental. While the pathogenesis of AS is not completely understood, it is thought to be an immune-mediated disease involving inflammatory cellular infiltrates, and human leukocyte antigen-B27. Currently, there is no specific diagnostic technique available for this disease; therefore conventional diagnostic approaches such as clinical symptoms, laboratory tests and imaging techniques are used. There are various review papers that have been published on conventional treatment approaches, and in this review work, we focus on the more promising nanomedicine-based treatment modalities to move this field forward.Keywords: ankylosing spondylitis, pathogenesis, genetic factors, environmental factors, treatment approaches
format	article
author	Xi Y Jiang T Chaurasiya B Zhou Y Yu J Wen J Shen Y Ye X Webster TJ
author_facet	Xi Y Jiang T Chaurasiya B Zhou Y Yu J Wen J Shen Y Ye X Webster TJ
author_sort	Xi Y
title	Advances in nanomedicine for the treatment of ankylosing spondylitis
title_short	Advances in nanomedicine for the treatment of ankylosing spondylitis
title_full	Advances in nanomedicine for the treatment of ankylosing spondylitis
title_fullStr	Advances in nanomedicine for the treatment of ankylosing spondylitis
title_full_unstemmed	Advances in nanomedicine for the treatment of ankylosing spondylitis
title_sort	advances in nanomedicine for the treatment of ankylosing spondylitis
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/f8722d356e9043af9e21a346840c7ae9
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Advances in nanomedicine for the treatment of ankylosing spondylitis

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