Application of Polymeric Nanocarriers for Enhancing the Bioavailability of Antibiotics at the Target Site and Overcoming Antimicrobial Resistance

Antimicrobial resistance is one of the greatest threats to global health. Although the efforts in antibiotic drug discovery continue to play a pivotal role, this solution alone probably will not be enough to ensure the required level of infection control in the future. New strategies and innovative...

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Autores principales:	Hung Le, Carole Karakasyan, Thierry Jouenne, Didier Le Cerf, Emmanuelle Dé
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	antimicrobial resistance polymeric nanocarrier antibiotic local bioavailability controlled release targeted delivery Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/f8746c270833421f808892fe5d86809c
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spelling	oai:doaj.org-article:f8746c270833421f808892fe5d86809c2021-11-25T16:35:35ZApplication of Polymeric Nanocarriers for Enhancing the Bioavailability of Antibiotics at the Target Site and Overcoming Antimicrobial Resistance10.3390/app1122106952076-3417https://doaj.org/article/f8746c270833421f808892fe5d86809c2021-11-01T00:00:00Zhttps://www.mdpi.com/2076-3417/11/22/10695https://doaj.org/toc/2076-3417Antimicrobial resistance is one of the greatest threats to global health. Although the efforts in antibiotic drug discovery continue to play a pivotal role, this solution alone probably will not be enough to ensure the required level of infection control in the future. New strategies and innovative modes of action are desperately needed to preserve the effectiveness of antimicrobials. Accordingly, antibiotic delivery based on polymeric nanoparticles is one of the possible methods that has been recently explored to improve their pharmacokinetic profile. Through optimized access of antibiotics to their sites of action, nanocarriers can unlock the full potential of the antibiotic cargoes, extend the antimicrobial spectrum, and reduce the required dose of antibiotic while preserving efficacy. Additionally, the use of an antibiotic-loaded nanocarrier is also considered a steady solution as novel molecules can be continuously developed and incorporated into the delivery platform. This review describes the present state of polymeric nanocarriers in enhancing antibiotic treatment, including improved pharmacokinetic properties and restored antibiotic efficacy against drug-resistant bacteria. Additionally, the current challenges and the future direction of this field are discussed.Hung LeCarole KarakasyanThierry JouenneDidier Le CerfEmmanuelle DéMDPI AGarticleantimicrobial resistancepolymeric nanocarrierantibioticlocal bioavailabilitycontrolled releasetargeted deliveryTechnologyTEngineering (General). Civil engineering (General)TA1-2040Biology (General)QH301-705.5PhysicsQC1-999ChemistryQD1-999ENApplied Sciences, Vol 11, Iss 10695, p 10695 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	antimicrobial resistance polymeric nanocarrier antibiotic local bioavailability controlled release targeted delivery Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
spellingShingle	antimicrobial resistance polymeric nanocarrier antibiotic local bioavailability controlled release targeted delivery Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999 Hung Le Carole Karakasyan Thierry Jouenne Didier Le Cerf Emmanuelle Dé Application of Polymeric Nanocarriers for Enhancing the Bioavailability of Antibiotics at the Target Site and Overcoming Antimicrobial Resistance
description	Antimicrobial resistance is one of the greatest threats to global health. Although the efforts in antibiotic drug discovery continue to play a pivotal role, this solution alone probably will not be enough to ensure the required level of infection control in the future. New strategies and innovative modes of action are desperately needed to preserve the effectiveness of antimicrobials. Accordingly, antibiotic delivery based on polymeric nanoparticles is one of the possible methods that has been recently explored to improve their pharmacokinetic profile. Through optimized access of antibiotics to their sites of action, nanocarriers can unlock the full potential of the antibiotic cargoes, extend the antimicrobial spectrum, and reduce the required dose of antibiotic while preserving efficacy. Additionally, the use of an antibiotic-loaded nanocarrier is also considered a steady solution as novel molecules can be continuously developed and incorporated into the delivery platform. This review describes the present state of polymeric nanocarriers in enhancing antibiotic treatment, including improved pharmacokinetic properties and restored antibiotic efficacy against drug-resistant bacteria. Additionally, the current challenges and the future direction of this field are discussed.
format	article
author	Hung Le Carole Karakasyan Thierry Jouenne Didier Le Cerf Emmanuelle Dé
author_facet	Hung Le Carole Karakasyan Thierry Jouenne Didier Le Cerf Emmanuelle Dé
author_sort	Hung Le
title	Application of Polymeric Nanocarriers for Enhancing the Bioavailability of Antibiotics at the Target Site and Overcoming Antimicrobial Resistance
title_short	Application of Polymeric Nanocarriers for Enhancing the Bioavailability of Antibiotics at the Target Site and Overcoming Antimicrobial Resistance
title_full	Application of Polymeric Nanocarriers for Enhancing the Bioavailability of Antibiotics at the Target Site and Overcoming Antimicrobial Resistance
title_fullStr	Application of Polymeric Nanocarriers for Enhancing the Bioavailability of Antibiotics at the Target Site and Overcoming Antimicrobial Resistance
title_full_unstemmed	Application of Polymeric Nanocarriers for Enhancing the Bioavailability of Antibiotics at the Target Site and Overcoming Antimicrobial Resistance
title_sort	application of polymeric nanocarriers for enhancing the bioavailability of antibiotics at the target site and overcoming antimicrobial resistance
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/f8746c270833421f808892fe5d86809c
work_keys_str_mv	AT hungle applicationofpolymericnanocarriersforenhancingthebioavailabilityofantibioticsatthetargetsiteandovercomingantimicrobialresistance AT carolekarakasyan applicationofpolymericnanocarriersforenhancingthebioavailabilityofantibioticsatthetargetsiteandovercomingantimicrobialresistance AT thierryjouenne applicationofpolymericnanocarriersforenhancingthebioavailabilityofantibioticsatthetargetsiteandovercomingantimicrobialresistance AT didierlecerf applicationofpolymericnanocarriersforenhancingthebioavailabilityofantibioticsatthetargetsiteandovercomingantimicrobialresistance AT emmanuellede applicationofpolymericnanocarriersforenhancingthebioavailabilityofantibioticsatthetargetsiteandovercomingantimicrobialresistance
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Application of Polymeric Nanocarriers for Enhancing the Bioavailability of Antibiotics at the Target Site and Overcoming Antimicrobial Resistance

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