Development of CRISPR-Cas13a-based antimicrobials capable of sequence-specific killing of target bacteria

Development of CRISPR-Cas13a-based antimicrobials capable of sequence-specific killing of target bacteria

CRISPR technology is emerging as a potential antimicrobial against antimicrobial-resistant bacteria. Here the authors develop a bacteriophage delivered Cas13a system for killing target bacteria and detecting bacterial genes.

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Autores principales: Kotaro Kiga, Xin-Ee Tan, Rodrigo Ibarra-Chávez, Shinya Watanabe, Yoshifumi Aiba, Yusuke Sato’o, Feng-Yu Li, Teppei Sasahara, Bintao Cui, Moriyuki Kawauchi, Tanit Boonsiri, Kanate Thitiananpakorn, Yusuke Taki, Aa Haeruman Azam, Masato Suzuki, José R. Penadés, Longzhu Cui
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Q
Acceso en línea:https://doaj.org/article/f87529d3a0c642c78aab97a22b66d12b
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spelling oai:doaj.org-article:f87529d3a0c642c78aab97a22b66d12b2021-12-02T17:30:39ZDevelopment of CRISPR-Cas13a-based antimicrobials capable of sequence-specific killing of target bacteria10.1038/s41467-020-16731-62041-1723https://doaj.org/article/f87529d3a0c642c78aab97a22b66d12b2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16731-6https://doaj.org/toc/2041-1723CRISPR technology is emerging as a potential antimicrobial against antimicrobial-resistant bacteria. Here the authors develop a bacteriophage delivered Cas13a system for killing target bacteria and detecting bacterial genes.Kotaro KigaXin-Ee TanRodrigo Ibarra-ChávezShinya WatanabeYoshifumi AibaYusuke Sato’oFeng-Yu LiTeppei SasaharaBintao CuiMoriyuki KawauchiTanit BoonsiriKanate ThitiananpakornYusuke TakiAa Haeruman AzamMasato SuzukiJosé R. PenadésLongzhu CuiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Kotaro Kiga
Xin-Ee Tan
Rodrigo Ibarra-Chávez
Shinya Watanabe
Yoshifumi Aiba
Yusuke Sato’o
Feng-Yu Li
Teppei Sasahara
Bintao Cui
Moriyuki Kawauchi
Tanit Boonsiri
Kanate Thitiananpakorn
Yusuke Taki
Aa Haeruman Azam
Masato Suzuki
José R. Penadés
Longzhu Cui
Development of CRISPR-Cas13a-based antimicrobials capable of sequence-specific killing of target bacteria
description CRISPR technology is emerging as a potential antimicrobial against antimicrobial-resistant bacteria. Here the authors develop a bacteriophage delivered Cas13a system for killing target bacteria and detecting bacterial genes.
format article
author Kotaro Kiga
Xin-Ee Tan
Rodrigo Ibarra-Chávez
Shinya Watanabe
Yoshifumi Aiba
Yusuke Sato’o
Feng-Yu Li
Teppei Sasahara
Bintao Cui
Moriyuki Kawauchi
Tanit Boonsiri
Kanate Thitiananpakorn
Yusuke Taki
Aa Haeruman Azam
Masato Suzuki
José R. Penadés
Longzhu Cui
author_facet Kotaro Kiga
Xin-Ee Tan
Rodrigo Ibarra-Chávez
Shinya Watanabe
Yoshifumi Aiba
Yusuke Sato’o
Feng-Yu Li
Teppei Sasahara
Bintao Cui
Moriyuki Kawauchi
Tanit Boonsiri
Kanate Thitiananpakorn
Yusuke Taki
Aa Haeruman Azam
Masato Suzuki
José R. Penadés
Longzhu Cui
author_sort Kotaro Kiga
title Development of CRISPR-Cas13a-based antimicrobials capable of sequence-specific killing of target bacteria
title_short Development of CRISPR-Cas13a-based antimicrobials capable of sequence-specific killing of target bacteria
title_full Development of CRISPR-Cas13a-based antimicrobials capable of sequence-specific killing of target bacteria
title_fullStr Development of CRISPR-Cas13a-based antimicrobials capable of sequence-specific killing of target bacteria
title_full_unstemmed Development of CRISPR-Cas13a-based antimicrobials capable of sequence-specific killing of target bacteria
title_sort development of crispr-cas13a-based antimicrobials capable of sequence-specific killing of target bacteria
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/f87529d3a0c642c78aab97a22b66d12b
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