Gold quantum dots impair the tumorigenic potential of glioma stem-like cells via β-catenin downregulation in vitro

Gold quantum dots impair the tumorigenic potential of glioma stem-like cells via β-catenin downregulation in vitro

Rizwan Wahab,1,2,* Neha Kaushik,3,* Farheen Khan,4 Nagendra Kumar Kaushik,5 Su-Jae Lee,3 Eun Ha Choi,5 Abdulaziz A Al-Khedhairy1 1Zoology Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia; 2Al-Jeraisy, Chair for DNA Research, King Saud University, Riyadh 11451, Saudi...

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Main Authors: Wahab R, Kaushik N, Khan F, Kaushik NK, Lee SJ, Choi EH, Al-Khedhairy AA
Format: article
Language:EN
Published: Dove Medical Press 2019
Subjects:
Multivarient gold nanoparticles
Quantum dots
LOD
LOQ
Glioma
Cancer stem like cells
Epithelial mesenchymal transition.
Medicine (General)
R5-920
Online Access:https://doaj.org/article/f877c07c20f54633b36511342da45f71
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spelling oai:doaj.org-article:f877c07c20f54633b36511342da45f712021-12-02T02:17:37ZGold quantum dots impair the tumorigenic potential of glioma stem-like cells via β-catenin downregulation in vitro1178-2013https://doaj.org/article/f877c07c20f54633b36511342da45f712019-02-01T00:00:00Zhttps://www.dovepress.com/gold-quantum-dots-impair-the-tumorigenic-potential-of-glioma-stem-like-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Rizwan Wahab,1,2,* Neha Kaushik,3,* Farheen Khan,4 Nagendra Kumar Kaushik,5 Su-Jae Lee,3 Eun Ha Choi,5 Abdulaziz A Al-Khedhairy1 1Zoology Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia; 2Al-Jeraisy, Chair for DNA Research, King Saud University, Riyadh 11451, Saudi Arabia; 3Department of Life Science, Hanyang University, Seoul 04763, South Korea; 4Chemistry Department, Faculty of Science, Taibah University, Yanbu 42353, Saudi Arabia; 5Plasma Bioscience Research Center/Applied Plasma Medicine Center, Department of Electrical and Biological Physics, Kwangwoon University, Seoul 01897, South Korea *These authors contributed equally to this work Background: Over the past several decades, the incidence of solid cancers has rapidly increased worldwide. Successful removal of tumor-initiating cells within tumors is essential in the field of cancer therapeutics to improve patient disease-free survival rates. The biocompatible multivarient-sized gold nanoparticles (MVS-GNPs) from quantum dots (QDs, Methods: Herein, MVS-GNPs synthesized and characterized by means of X-ray diffraction pattern (XRD) and transmission electron microscopy (TEM) techniques. Afterwards, interaction of these GNPs with glioma stem-cell like cells along with cancer cells were evaluated by MTT, cell motility, self-renewal assays and biostatistics was also applied.Results: Among these GNPs, G-QDs contributed to reduce metastatic events and spheroid cell growth, potentially blocking the self-renewal ability of these cells. This study also uncovers the previously unknown role of the inhibition of CTNNB1 signaling as a novel candidate to decrease the tumorigenesis of glioma spheroids and subsequent spheroid growth. The accurate and precise biostatistics results were obtained at quantify level.Conclusion: In summary, G-QDs may exhibit possible contribution on suppressing the growth of tumor-initiating cells. These data reveal a unique therapeutic approach for the elimination of residual resistant stem-like cells during cancer treatment. Keywords: multivarient gold nanoparticles, epithelial-mesenchymal transition, solid tumor, brain cancer, self-renewal, cellular movement, biostatisticsWahab RKaushik NKhan FKaushik NKLee SJChoi EHAl-Khedhairy AADove Medical PressarticleMultivarient gold nanoparticlesQuantum dotsLODLOQGliomaCancer stem like cellsEpithelial mesenchymal transition.Medicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 1131-1148 (2019)
institution DOAJ
collection DOAJ
language EN
topic Multivarient gold nanoparticles
Quantum dots
LOD
LOQ
Glioma
Cancer stem like cells
Epithelial mesenchymal transition.
Medicine (General)
R5-920
spellingShingle Multivarient gold nanoparticles
Quantum dots
LOD
LOQ
Glioma
Cancer stem like cells
Epithelial mesenchymal transition.
Medicine (General)
R5-920
Wahab R
Kaushik N
Khan F
Kaushik NK
Lee SJ
Choi EH
Al-Khedhairy AA
Gold quantum dots impair the tumorigenic potential of glioma stem-like cells via β-catenin downregulation in vitro
description Rizwan Wahab,1,2,* Neha Kaushik,3,* Farheen Khan,4 Nagendra Kumar Kaushik,5 Su-Jae Lee,3 Eun Ha Choi,5 Abdulaziz A Al-Khedhairy1 1Zoology Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia; 2Al-Jeraisy, Chair for DNA Research, King Saud University, Riyadh 11451, Saudi Arabia; 3Department of Life Science, Hanyang University, Seoul 04763, South Korea; 4Chemistry Department, Faculty of Science, Taibah University, Yanbu 42353, Saudi Arabia; 5Plasma Bioscience Research Center/Applied Plasma Medicine Center, Department of Electrical and Biological Physics, Kwangwoon University, Seoul 01897, South Korea *These authors contributed equally to this work Background: Over the past several decades, the incidence of solid cancers has rapidly increased worldwide. Successful removal of tumor-initiating cells within tumors is essential in the field of cancer therapeutics to improve patient disease-free survival rates. The biocompatible multivarient-sized gold nanoparticles (MVS-GNPs) from quantum dots (QDs, Methods: Herein, MVS-GNPs synthesized and characterized by means of X-ray diffraction pattern (XRD) and transmission electron microscopy (TEM) techniques. Afterwards, interaction of these GNPs with glioma stem-cell like cells along with cancer cells were evaluated by MTT, cell motility, self-renewal assays and biostatistics was also applied.Results: Among these GNPs, G-QDs contributed to reduce metastatic events and spheroid cell growth, potentially blocking the self-renewal ability of these cells. This study also uncovers the previously unknown role of the inhibition of CTNNB1 signaling as a novel candidate to decrease the tumorigenesis of glioma spheroids and subsequent spheroid growth. The accurate and precise biostatistics results were obtained at quantify level.Conclusion: In summary, G-QDs may exhibit possible contribution on suppressing the growth of tumor-initiating cells. These data reveal a unique therapeutic approach for the elimination of residual resistant stem-like cells during cancer treatment. Keywords: multivarient gold nanoparticles, epithelial-mesenchymal transition, solid tumor, brain cancer, self-renewal, cellular movement, biostatistics
format article
author Wahab R
Kaushik N
Khan F
Kaushik NK
Lee SJ
Choi EH
Al-Khedhairy AA
author_facet Wahab R
Kaushik N
Khan F
Kaushik NK
Lee SJ
Choi EH
Al-Khedhairy AA
author_sort Wahab R
title Gold quantum dots impair the tumorigenic potential of glioma stem-like cells via β-catenin downregulation in vitro
title_short Gold quantum dots impair the tumorigenic potential of glioma stem-like cells via β-catenin downregulation in vitro
title_full Gold quantum dots impair the tumorigenic potential of glioma stem-like cells via β-catenin downregulation in vitro
title_fullStr Gold quantum dots impair the tumorigenic potential of glioma stem-like cells via β-catenin downregulation in vitro
title_full_unstemmed Gold quantum dots impair the tumorigenic potential of glioma stem-like cells via β-catenin downregulation in vitro
title_sort gold quantum dots impair the tumorigenic potential of glioma stem-like cells via β-catenin downregulation in vitro
publisher Dove Medical Press
publishDate 2019
url https://doaj.org/article/f877c07c20f54633b36511342da45f71
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