Fasting induces a subcutaneous-to-visceral fat switch mediated by microRNA-149-3p and suppression of PRDM16

Visceral adiposity is associated with metabolic diseases, whereas subcutaneous adiposity is comparatively benign. Here, the authors report that subcutaneous adipose tissue adopts visceral-like characteristics in response to prolonged fasting, and show this is mediated by miR-149-3p and its target, P...

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Autores principales: Hanying Ding, Shasha Zheng, Daniel Garcia-Ruiz, Dongxia Hou, Zhe Wei, Zhicong Liao, Limin Li, Yujing Zhang, Xiao Han, Ke Zen, Chen-Yu Zhang, Jing Li, Xiaohong Jiang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/f877f6cf92a7471b819414666df8c0fe
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Sumario:Visceral adiposity is associated with metabolic diseases, whereas subcutaneous adiposity is comparatively benign. Here, the authors report that subcutaneous adipose tissue adopts visceral-like characteristics in response to prolonged fasting, and show this is mediated by miR-149-3p and its target, PRDM16.