Human Coronavirus EMC Is Not the Same as Severe Acute Respiratory Syndrome Coronavirus

ABSTRACT A newly identified betacoronavirus, human coronavirus EMC (HCoV-EMC), has been isolated from several patients with respiratory and renal disease in the Middle East. While only a few infected patients have been identified, the mortality of the infection is greater than 50%. Like its better-k...

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Autores principales:	Stanley Perlman, Jincun Zhao
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2013
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/f8796aab15854b7dababbbaa640cb4cb
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spelling	oai:doaj.org-article:f8796aab15854b7dababbbaa640cb4cb2021-11-15T15:40:25ZHuman Coronavirus EMC Is Not the Same as Severe Acute Respiratory Syndrome Coronavirus10.1128/mBio.00002-132150-7511https://doaj.org/article/f8796aab15854b7dababbbaa640cb4cb2013-03-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00002-13https://doaj.org/toc/2150-7511ABSTRACT A newly identified betacoronavirus, human coronavirus EMC (HCoV-EMC), has been isolated from several patients with respiratory and renal disease in the Middle East. While only a few infected patients have been identified, the mortality of the infection is greater than 50%. Like its better-known cousin severe acute respiratory syndrome coronavirus (SARS-CoV), HCoV-EMC appears to have originated from bats. In a recent article in mBio, Müller et al. described several important differences between the two viruses [M. A. Müller et al., mBio 3(6):e00515-12, 2012, doi:10.1128/mBio.00515-12]. Unlike SARS-CoV, HCoV-EMC can directly infect bat cells. As important, HCoV-EMC does not enter cells using the SARS-CoV receptor, human angiotensin-converting receptor-2 (hACE2). These results provide a strong incentive for identifying the host cell receptor used by HCoV-EMC. Identification of the receptor will provide insight into the pathogenesis of pulmonary and renal disease and may also suggest novel therapeutic interventions.Stanley PerlmanJincun ZhaoAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 4, Iss 1 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Stanley Perlman Jincun Zhao Human Coronavirus EMC Is Not the Same as Severe Acute Respiratory Syndrome Coronavirus
description	ABSTRACT A newly identified betacoronavirus, human coronavirus EMC (HCoV-EMC), has been isolated from several patients with respiratory and renal disease in the Middle East. While only a few infected patients have been identified, the mortality of the infection is greater than 50%. Like its better-known cousin severe acute respiratory syndrome coronavirus (SARS-CoV), HCoV-EMC appears to have originated from bats. In a recent article in mBio, Müller et al. described several important differences between the two viruses [M. A. Müller et al., mBio 3(6):e00515-12, 2012, doi:10.1128/mBio.00515-12]. Unlike SARS-CoV, HCoV-EMC can directly infect bat cells. As important, HCoV-EMC does not enter cells using the SARS-CoV receptor, human angiotensin-converting receptor-2 (hACE2). These results provide a strong incentive for identifying the host cell receptor used by HCoV-EMC. Identification of the receptor will provide insight into the pathogenesis of pulmonary and renal disease and may also suggest novel therapeutic interventions.
format	article
author	Stanley Perlman Jincun Zhao
author_facet	Stanley Perlman Jincun Zhao
author_sort	Stanley Perlman
title	Human Coronavirus EMC Is Not the Same as Severe Acute Respiratory Syndrome Coronavirus
title_short	Human Coronavirus EMC Is Not the Same as Severe Acute Respiratory Syndrome Coronavirus
title_full	Human Coronavirus EMC Is Not the Same as Severe Acute Respiratory Syndrome Coronavirus
title_fullStr	Human Coronavirus EMC Is Not the Same as Severe Acute Respiratory Syndrome Coronavirus
title_full_unstemmed	Human Coronavirus EMC Is Not the Same as Severe Acute Respiratory Syndrome Coronavirus
title_sort	human coronavirus emc is not the same as severe acute respiratory syndrome coronavirus
publisher	American Society for Microbiology
publishDate	2013
url	https://doaj.org/article/f8796aab15854b7dababbbaa640cb4cb
work_keys_str_mv	AT stanleyperlman humancoronavirusemcisnotthesameassevereacuterespiratorysyndromecoronavirus AT jincunzhao humancoronavirusemcisnotthesameassevereacuterespiratorysyndromecoronavirus
_version_	1718427803596095488

Human Coronavirus EMC Is Not the Same as Severe Acute Respiratory Syndrome Coronavirus

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