Follistatin like-1 aggravates silica-induced mouse lung injury

Abstract Occupational inhalation of dust, such as crystalline silica, for prolonged periods in the workplace leads to fibrotic lung diseases worldwide. The mechanisms underlying the diseases are unknown, so that no effective treatment exists for these conditions. We found elevated levels of follista...

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Autores principales:	Yinshan Fang, Si Zhang, Xiaohe Li, Fangxin Jiang, Qiao Ye, Wen Ning
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f87cb8a5f8e14970a88b7d22e5ecf7c9
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spelling	oai:doaj.org-article:f87cb8a5f8e14970a88b7d22e5ecf7c92021-12-02T11:52:43ZFollistatin like-1 aggravates silica-induced mouse lung injury10.1038/s41598-017-00478-02045-2322https://doaj.org/article/f87cb8a5f8e14970a88b7d22e5ecf7c92017-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00478-0https://doaj.org/toc/2045-2322Abstract Occupational inhalation of dust, such as crystalline silica, for prolonged periods in the workplace leads to fibrotic lung diseases worldwide. The mechanisms underlying the diseases are unknown, so that no effective treatment exists for these conditions. We found elevated levels of follistatin like 1 (FSTL1) in serum from patients with silicosis and in lungs from silica-induced mouse model. The induced Fstl1 regulated inflammation response via activation of nod-like receptor family, pyrin domain containing 3v (NLRP3) inflammasome-mediated IL-1β production from macrophages. Meanwhile, Fstl1 promoted fibrosis via positive regulation of TGF-β1 signaling. Haploinsufficiency of Fstl1 or blockage of FSTL1 with a neutralizing antibody was protective from silica-induced lung injury in mice in vivo. Our data suggest that Fstl1 plays an important role in lung fibrosis, and may serve as a novel therapeutic target for treatment of silicosis.Yinshan FangSi ZhangXiaohe LiFangxin JiangQiao YeWen NingNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yinshan Fang Si Zhang Xiaohe Li Fangxin Jiang Qiao Ye Wen Ning Follistatin like-1 aggravates silica-induced mouse lung injury
description	Abstract Occupational inhalation of dust, such as crystalline silica, for prolonged periods in the workplace leads to fibrotic lung diseases worldwide. The mechanisms underlying the diseases are unknown, so that no effective treatment exists for these conditions. We found elevated levels of follistatin like 1 (FSTL1) in serum from patients with silicosis and in lungs from silica-induced mouse model. The induced Fstl1 regulated inflammation response via activation of nod-like receptor family, pyrin domain containing 3v (NLRP3) inflammasome-mediated IL-1β production from macrophages. Meanwhile, Fstl1 promoted fibrosis via positive regulation of TGF-β1 signaling. Haploinsufficiency of Fstl1 or blockage of FSTL1 with a neutralizing antibody was protective from silica-induced lung injury in mice in vivo. Our data suggest that Fstl1 plays an important role in lung fibrosis, and may serve as a novel therapeutic target for treatment of silicosis.
format	article
author	Yinshan Fang Si Zhang Xiaohe Li Fangxin Jiang Qiao Ye Wen Ning
author_facet	Yinshan Fang Si Zhang Xiaohe Li Fangxin Jiang Qiao Ye Wen Ning
author_sort	Yinshan Fang
title	Follistatin like-1 aggravates silica-induced mouse lung injury
title_short	Follistatin like-1 aggravates silica-induced mouse lung injury
title_full	Follistatin like-1 aggravates silica-induced mouse lung injury
title_fullStr	Follistatin like-1 aggravates silica-induced mouse lung injury
title_full_unstemmed	Follistatin like-1 aggravates silica-induced mouse lung injury
title_sort	follistatin like-1 aggravates silica-induced mouse lung injury
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f87cb8a5f8e14970a88b7d22e5ecf7c9
work_keys_str_mv	AT yinshanfang follistatinlike1aggravatessilicainducedmouselunginjury AT sizhang follistatinlike1aggravatessilicainducedmouselunginjury AT xiaoheli follistatinlike1aggravatessilicainducedmouselunginjury AT fangxinjiang follistatinlike1aggravatessilicainducedmouselunginjury AT qiaoye follistatinlike1aggravatessilicainducedmouselunginjury AT wenning follistatinlike1aggravatessilicainducedmouselunginjury
_version_	1718394963077627904

Follistatin like-1 aggravates silica-induced mouse lung injury

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