C-reactive protein as an early biomarker for malaria infection and monitoring of malaria severity: a meta-analysis

Abstract This study investigated whether C-reactive protein (CRP) can be used as a marker for the early detection and monitoring of malaria severity. Potentially relevant studies were searched in Medline (PubMed), Scopus, and Web of Science. Differences in CRP between (1) severe malaria and uncompli...

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Autores principales:	Polrat Wilairatana, Praphassorn Mahannop, Thanita Tussato, I-mee Hayeedoloh, Rachasak Boonhok, Wiyada Kwanhian Klangbud, Wanida Mala, Kwuntida Uthaisar Kotepui, Manas Kotepui
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f87dc56564004370aab34e934f0c046f
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spelling	oai:doaj.org-article:f87dc56564004370aab34e934f0c046f2021-11-14T12:21:39ZC-reactive protein as an early biomarker for malaria infection and monitoring of malaria severity: a meta-analysis10.1038/s41598-021-01556-02045-2322https://doaj.org/article/f87dc56564004370aab34e934f0c046f2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01556-0https://doaj.org/toc/2045-2322Abstract This study investigated whether C-reactive protein (CRP) can be used as a marker for the early detection and monitoring of malaria severity. Potentially relevant studies were searched in Medline (PubMed), Scopus, and Web of Science. Differences in CRP between (1) severe malaria and uncomplicated malaria, (2) uncomplicated malaria and asymptomatic malaria, (3) uncomplicated malaria and febrile/healthy controls, and (4) asymptomatic malaria and febrile/healthy controls were estimated using random-effects models. Twenty-nine studies were included for meta-analysis. The results of meta-analysis demonstrated higher mean CRP levels in (1) patients with severe malaria compared with uncomplicated malaria (p < 0.001, standard mean difference [SMD]: 1.52, 95% confidence interval [CI]: 0.91–2.12, I2: 95.1%), (2) patients with uncomplicated malaria than in those with asymptomatic malaria (p: 0.001, SMD: 1.65, 95% CI: 0.67–2.62, I2: 96.7%), (3) patients with uncomplicated malaria compared with febrile/healthy controls (p < 0.001, SMD: 2.38, 95% CI: 1.37–3.40, I2: 98.5%), and (4) patients with asymptomatic malaria compared with febrile/healthy controls (p < 0.001, SMD: 2.55, 95% CI: 1.60–3.50, I2: 99.2%). This study demonstrated CRP levels are a biomarker for the early detection and monitoring of malaria severity.Polrat WilairatanaPraphassorn MahannopThanita TussatoI-mee HayeedolohRachasak BoonhokWiyada Kwanhian KlangbudWanida MalaKwuntida Uthaisar KotepuiManas KotepuiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-20 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Polrat Wilairatana Praphassorn Mahannop Thanita Tussato I-mee Hayeedoloh Rachasak Boonhok Wiyada Kwanhian Klangbud Wanida Mala Kwuntida Uthaisar Kotepui Manas Kotepui C-reactive protein as an early biomarker for malaria infection and monitoring of malaria severity: a meta-analysis
description	Abstract This study investigated whether C-reactive protein (CRP) can be used as a marker for the early detection and monitoring of malaria severity. Potentially relevant studies were searched in Medline (PubMed), Scopus, and Web of Science. Differences in CRP between (1) severe malaria and uncomplicated malaria, (2) uncomplicated malaria and asymptomatic malaria, (3) uncomplicated malaria and febrile/healthy controls, and (4) asymptomatic malaria and febrile/healthy controls were estimated using random-effects models. Twenty-nine studies were included for meta-analysis. The results of meta-analysis demonstrated higher mean CRP levels in (1) patients with severe malaria compared with uncomplicated malaria (p < 0.001, standard mean difference [SMD]: 1.52, 95% confidence interval [CI]: 0.91–2.12, I2: 95.1%), (2) patients with uncomplicated malaria than in those with asymptomatic malaria (p: 0.001, SMD: 1.65, 95% CI: 0.67–2.62, I2: 96.7%), (3) patients with uncomplicated malaria compared with febrile/healthy controls (p < 0.001, SMD: 2.38, 95% CI: 1.37–3.40, I2: 98.5%), and (4) patients with asymptomatic malaria compared with febrile/healthy controls (p < 0.001, SMD: 2.55, 95% CI: 1.60–3.50, I2: 99.2%). This study demonstrated CRP levels are a biomarker for the early detection and monitoring of malaria severity.
format	article
author	Polrat Wilairatana Praphassorn Mahannop Thanita Tussato I-mee Hayeedoloh Rachasak Boonhok Wiyada Kwanhian Klangbud Wanida Mala Kwuntida Uthaisar Kotepui Manas Kotepui
author_facet	Polrat Wilairatana Praphassorn Mahannop Thanita Tussato I-mee Hayeedoloh Rachasak Boonhok Wiyada Kwanhian Klangbud Wanida Mala Kwuntida Uthaisar Kotepui Manas Kotepui
author_sort	Polrat Wilairatana
title	C-reactive protein as an early biomarker for malaria infection and monitoring of malaria severity: a meta-analysis
title_short	C-reactive protein as an early biomarker for malaria infection and monitoring of malaria severity: a meta-analysis
title_full	C-reactive protein as an early biomarker for malaria infection and monitoring of malaria severity: a meta-analysis
title_fullStr	C-reactive protein as an early biomarker for malaria infection and monitoring of malaria severity: a meta-analysis
title_full_unstemmed	C-reactive protein as an early biomarker for malaria infection and monitoring of malaria severity: a meta-analysis
title_sort	c-reactive protein as an early biomarker for malaria infection and monitoring of malaria severity: a meta-analysis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f87dc56564004370aab34e934f0c046f
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C-reactive protein as an early biomarker for malaria infection and monitoring of malaria severity: a meta-analysis

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