Using all-cause mortality to define severe RV dilation with RV/LV volume ratio

Abstract Right ventricular (RV) end-diastolic volume (EDV) to left ventricular (LV) EDV ratio using cardiovascular magnetic resonance imaging (CMR) is an important parameter for RV size evaluation in additional to indexed EDV. We explore the severity partition for RV dilation using mortality in a po...

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Autores principales:	Stephan P. L. Altmayer, Q. Joyce Han, Karima Addetia, Amit R. Patel, Paul R. Forfia, Yuchi Han
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f87ef9adf57847b3a2482ced88837d35
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spelling	oai:doaj.org-article:f87ef9adf57847b3a2482ced88837d352021-12-02T15:08:24ZUsing all-cause mortality to define severe RV dilation with RV/LV volume ratio10.1038/s41598-018-25259-12045-2322https://doaj.org/article/f87ef9adf57847b3a2482ced88837d352018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-25259-1https://doaj.org/toc/2045-2322Abstract Right ventricular (RV) end-diastolic volume (EDV) to left ventricular (LV) EDV ratio using cardiovascular magnetic resonance imaging (CMR) is an important parameter for RV size evaluation in additional to indexed EDV. We explore the severity partition for RV dilation using mortality in a population of 62 patients with pulmonary hypertension (PH). Cine short-axis images were acquired with a 1.5 T MR scanner using a steady-state free precession sequence. The optimal cutoff to classify severe RV dilation was determined by a receiver-operating curve (ROC) analysis based on mortality. We further defined mild and moderate categories by the standard deviation distance between normal and severely dilated and found the categories RV dilation by RV/LV volume ratio to be “mild” (1.27–1.69), “moderate” (1.70–2.29) and “severe” (≥2.30). There were significant differences in RVEDV and RV ejection fraction between “mild”, “moderate” and “severe” groups (p < 0.001). The “severe” category had a significantly higher mortality when compared to the “non-severe” categories (p < 0.001) while there was no difference among the “non-severe” dilated groups. We have shown that severe RV dilation partition can be defined using mortality with RV/LV volume ratio, which offers an outcome based grading of the “severe” category of RV dilation.Stephan P. L. AltmayerQ. Joyce HanKarima AddetiaAmit R. PatelPaul R. ForfiaYuchi HanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Stephan P. L. Altmayer Q. Joyce Han Karima Addetia Amit R. Patel Paul R. Forfia Yuchi Han Using all-cause mortality to define severe RV dilation with RV/LV volume ratio
description	Abstract Right ventricular (RV) end-diastolic volume (EDV) to left ventricular (LV) EDV ratio using cardiovascular magnetic resonance imaging (CMR) is an important parameter for RV size evaluation in additional to indexed EDV. We explore the severity partition for RV dilation using mortality in a population of 62 patients with pulmonary hypertension (PH). Cine short-axis images were acquired with a 1.5 T MR scanner using a steady-state free precession sequence. The optimal cutoff to classify severe RV dilation was determined by a receiver-operating curve (ROC) analysis based on mortality. We further defined mild and moderate categories by the standard deviation distance between normal and severely dilated and found the categories RV dilation by RV/LV volume ratio to be “mild” (1.27–1.69), “moderate” (1.70–2.29) and “severe” (≥2.30). There were significant differences in RVEDV and RV ejection fraction between “mild”, “moderate” and “severe” groups (p < 0.001). The “severe” category had a significantly higher mortality when compared to the “non-severe” categories (p < 0.001) while there was no difference among the “non-severe” dilated groups. We have shown that severe RV dilation partition can be defined using mortality with RV/LV volume ratio, which offers an outcome based grading of the “severe” category of RV dilation.
format	article
author	Stephan P. L. Altmayer Q. Joyce Han Karima Addetia Amit R. Patel Paul R. Forfia Yuchi Han
author_facet	Stephan P. L. Altmayer Q. Joyce Han Karima Addetia Amit R. Patel Paul R. Forfia Yuchi Han
author_sort	Stephan P. L. Altmayer
title	Using all-cause mortality to define severe RV dilation with RV/LV volume ratio
title_short	Using all-cause mortality to define severe RV dilation with RV/LV volume ratio
title_full	Using all-cause mortality to define severe RV dilation with RV/LV volume ratio
title_fullStr	Using all-cause mortality to define severe RV dilation with RV/LV volume ratio
title_full_unstemmed	Using all-cause mortality to define severe RV dilation with RV/LV volume ratio
title_sort	using all-cause mortality to define severe rv dilation with rv/lv volume ratio
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/f87ef9adf57847b3a2482ced88837d35
work_keys_str_mv	AT stephanplaltmayer usingallcausemortalitytodefineseverervdilationwithrvlvvolumeratio AT qjoycehan usingallcausemortalitytodefineseverervdilationwithrvlvvolumeratio AT karimaaddetia usingallcausemortalitytodefineseverervdilationwithrvlvvolumeratio AT amitrpatel usingallcausemortalitytodefineseverervdilationwithrvlvvolumeratio AT paulrforfia usingallcausemortalitytodefineseverervdilationwithrvlvvolumeratio AT yuchihan usingallcausemortalitytodefineseverervdilationwithrvlvvolumeratio
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Using all-cause mortality to define severe RV dilation with RV/LV volume ratio

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