Retinal ganglion cell dysfunction in preclinical Alzheimer’s disease: an electrophysiologic biomarker signature

Abstract The current study evaluated retinal function using electroretinography (ERG) in cognitively healthy (CH) participants with preclinical Alzheimer’s disease (AD), as classified by cerebral spinal fluid (CSF) Aβ42/Tau ratio. Individuals with normal retinal morphology ascertained by spectral-do...

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Autores principales:	Samuel Asanad, Christian M. Felix, Michele Fantini, Michael G. Harrington, Alfredo A. Sadun, Rustum Karanjia
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f87f70fe13e448fc88e26ae7471dfe78
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spelling	oai:doaj.org-article:f87f70fe13e448fc88e26ae7471dfe782021-12-02T17:04:53ZRetinal ganglion cell dysfunction in preclinical Alzheimer’s disease: an electrophysiologic biomarker signature10.1038/s41598-021-85010-12045-2322https://doaj.org/article/f87f70fe13e448fc88e26ae7471dfe782021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85010-1https://doaj.org/toc/2045-2322Abstract The current study evaluated retinal function using electroretinography (ERG) in cognitively healthy (CH) participants with preclinical Alzheimer’s disease (AD), as classified by cerebral spinal fluid (CSF) Aβ42/Tau ratio. Individuals with normal retinal morphology ascertained by spectral-domain optical coherence tomography were enrolled. Full-field ERG, pattern PERG, and photopic negative response (PhNR) were performed in 29 adult participants (58 eyes). Amplitude and implicit times of the ERG wave components were analyzed. Preclinical AD participants showed marked retinal ganglion cell dysfunction relative to controls. The PhNR was significantly diminished in preclinical AD relative to controls. PhNR amplitude and N95 implicit time differentiated CH individuals with CSF biomarkers of AD pathology with 87% sensitivity and 82% specificity. These quantitative electrophysiologic findings expand our understanding of early retinal functional changes that precede cognitive decline in AD. Retinal ganglion cell dysfunction, as detected by ERG, may be a clinically useful, non-invasive in vivo biomarker for early disease detection, which is necessary for ultimately pursuing early intervention.Samuel AsanadChristian M. FelixMichele FantiniMichael G. HarringtonAlfredo A. SadunRustum KaranjiaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Samuel Asanad Christian M. Felix Michele Fantini Michael G. Harrington Alfredo A. Sadun Rustum Karanjia Retinal ganglion cell dysfunction in preclinical Alzheimer’s disease: an electrophysiologic biomarker signature
description	Abstract The current study evaluated retinal function using electroretinography (ERG) in cognitively healthy (CH) participants with preclinical Alzheimer’s disease (AD), as classified by cerebral spinal fluid (CSF) Aβ42/Tau ratio. Individuals with normal retinal morphology ascertained by spectral-domain optical coherence tomography were enrolled. Full-field ERG, pattern PERG, and photopic negative response (PhNR) were performed in 29 adult participants (58 eyes). Amplitude and implicit times of the ERG wave components were analyzed. Preclinical AD participants showed marked retinal ganglion cell dysfunction relative to controls. The PhNR was significantly diminished in preclinical AD relative to controls. PhNR amplitude and N95 implicit time differentiated CH individuals with CSF biomarkers of AD pathology with 87% sensitivity and 82% specificity. These quantitative electrophysiologic findings expand our understanding of early retinal functional changes that precede cognitive decline in AD. Retinal ganglion cell dysfunction, as detected by ERG, may be a clinically useful, non-invasive in vivo biomarker for early disease detection, which is necessary for ultimately pursuing early intervention.
format	article
author	Samuel Asanad Christian M. Felix Michele Fantini Michael G. Harrington Alfredo A. Sadun Rustum Karanjia
author_facet	Samuel Asanad Christian M. Felix Michele Fantini Michael G. Harrington Alfredo A. Sadun Rustum Karanjia
author_sort	Samuel Asanad
title	Retinal ganglion cell dysfunction in preclinical Alzheimer’s disease: an electrophysiologic biomarker signature
title_short	Retinal ganglion cell dysfunction in preclinical Alzheimer’s disease: an electrophysiologic biomarker signature
title_full	Retinal ganglion cell dysfunction in preclinical Alzheimer’s disease: an electrophysiologic biomarker signature
title_fullStr	Retinal ganglion cell dysfunction in preclinical Alzheimer’s disease: an electrophysiologic biomarker signature
title_full_unstemmed	Retinal ganglion cell dysfunction in preclinical Alzheimer’s disease: an electrophysiologic biomarker signature
title_sort	retinal ganglion cell dysfunction in preclinical alzheimer’s disease: an electrophysiologic biomarker signature
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f87f70fe13e448fc88e26ae7471dfe78
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Retinal ganglion cell dysfunction in preclinical Alzheimer’s disease: an electrophysiologic biomarker signature

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