Reduced sensitivity to delayed time and delayed reward of the post-operative insular glioma patients in delay discounting
Previous studies have shown that the insula is closely related to addiction, and the structure’s role in delay discounting can be measured by a specific task, but the specific role of the insula has been less studied. In this study, we first conducted a lesion study in which we recruited healthy con...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Elsevier
2022
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/f883fd0d15bf40c0837af9d306c38686 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:f883fd0d15bf40c0837af9d306c38686 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:f883fd0d15bf40c0837af9d306c386862021-12-04T04:34:00ZReduced sensitivity to delayed time and delayed reward of the post-operative insular glioma patients in delay discounting2213-158210.1016/j.nicl.2021.102895https://doaj.org/article/f883fd0d15bf40c0837af9d306c386862022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2213158221003399https://doaj.org/toc/2213-1582Previous studies have shown that the insula is closely related to addiction, and the structure’s role in delay discounting can be measured by a specific task, but the specific role of the insula has been less studied. In this study, we first conducted a lesion study in which we recruited healthy controls (n = 30) and patients with unilateral insula injury (n = 16) to complete a behavioral delay discounting task. Then we conducted a functional magnetic resonance imaging (fMRI) study, and a separate group healthy volunteers (n = 51) completed a delay discounting task during the fMRI scan. The lesion study showed a significant difference between the two groups in the delay discounting task, which revealed that insula injury was associated with impaired decision making. The fMRI study revealed choice-sensitive insula activation that was modulated by delayed time and delayed reward, indicating an important role of the insula in delay discounting. Overall, our results provide evidence for a role of the insular lobe in delay discounting and suggests that this structure may be considered an important factor in the future treatment and diagnosis of addiction disorders.Wenjin FuZhenxing HuangJun LiQi DongYang LiGen LiYaokai XuBowen XueZhenye LiChuansheng ChenShengjun SunYazhuo ZhangZonggang HouJian XieElsevierarticleDecision makingDelay discountingInsulaInsular gliomaComputer applications to medicine. Medical informaticsR858-859.7Neurology. Diseases of the nervous systemRC346-429ENNeuroImage: Clinical, Vol 33, Iss , Pp 102895- (2022) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Decision making Delay discounting Insula Insular glioma Computer applications to medicine. Medical informatics R858-859.7 Neurology. Diseases of the nervous system RC346-429 |
| spellingShingle |
Decision making Delay discounting Insula Insular glioma Computer applications to medicine. Medical informatics R858-859.7 Neurology. Diseases of the nervous system RC346-429 Wenjin Fu Zhenxing Huang Jun Li Qi Dong Yang Li Gen Li Yaokai Xu Bowen Xue Zhenye Li Chuansheng Chen Shengjun Sun Yazhuo Zhang Zonggang Hou Jian Xie Reduced sensitivity to delayed time and delayed reward of the post-operative insular glioma patients in delay discounting |
| description |
Previous studies have shown that the insula is closely related to addiction, and the structure’s role in delay discounting can be measured by a specific task, but the specific role of the insula has been less studied. In this study, we first conducted a lesion study in which we recruited healthy controls (n = 30) and patients with unilateral insula injury (n = 16) to complete a behavioral delay discounting task. Then we conducted a functional magnetic resonance imaging (fMRI) study, and a separate group healthy volunteers (n = 51) completed a delay discounting task during the fMRI scan. The lesion study showed a significant difference between the two groups in the delay discounting task, which revealed that insula injury was associated with impaired decision making. The fMRI study revealed choice-sensitive insula activation that was modulated by delayed time and delayed reward, indicating an important role of the insula in delay discounting. Overall, our results provide evidence for a role of the insular lobe in delay discounting and suggests that this structure may be considered an important factor in the future treatment and diagnosis of addiction disorders. |
| format |
article |
| author |
Wenjin Fu Zhenxing Huang Jun Li Qi Dong Yang Li Gen Li Yaokai Xu Bowen Xue Zhenye Li Chuansheng Chen Shengjun Sun Yazhuo Zhang Zonggang Hou Jian Xie |
| author_facet |
Wenjin Fu Zhenxing Huang Jun Li Qi Dong Yang Li Gen Li Yaokai Xu Bowen Xue Zhenye Li Chuansheng Chen Shengjun Sun Yazhuo Zhang Zonggang Hou Jian Xie |
| author_sort |
Wenjin Fu |
| title |
Reduced sensitivity to delayed time and delayed reward of the post-operative insular glioma patients in delay discounting |
| title_short |
Reduced sensitivity to delayed time and delayed reward of the post-operative insular glioma patients in delay discounting |
| title_full |
Reduced sensitivity to delayed time and delayed reward of the post-operative insular glioma patients in delay discounting |
| title_fullStr |
Reduced sensitivity to delayed time and delayed reward of the post-operative insular glioma patients in delay discounting |
| title_full_unstemmed |
Reduced sensitivity to delayed time and delayed reward of the post-operative insular glioma patients in delay discounting |
| title_sort |
reduced sensitivity to delayed time and delayed reward of the post-operative insular glioma patients in delay discounting |
| publisher |
Elsevier |
| publishDate |
2022 |
| url |
https://doaj.org/article/f883fd0d15bf40c0837af9d306c38686 |
| work_keys_str_mv |
AT wenjinfu reducedsensitivitytodelayedtimeanddelayedrewardofthepostoperativeinsulargliomapatientsindelaydiscounting AT zhenxinghuang reducedsensitivitytodelayedtimeanddelayedrewardofthepostoperativeinsulargliomapatientsindelaydiscounting AT junli reducedsensitivitytodelayedtimeanddelayedrewardofthepostoperativeinsulargliomapatientsindelaydiscounting AT qidong reducedsensitivitytodelayedtimeanddelayedrewardofthepostoperativeinsulargliomapatientsindelaydiscounting AT yangli reducedsensitivitytodelayedtimeanddelayedrewardofthepostoperativeinsulargliomapatientsindelaydiscounting AT genli reducedsensitivitytodelayedtimeanddelayedrewardofthepostoperativeinsulargliomapatientsindelaydiscounting AT yaokaixu reducedsensitivitytodelayedtimeanddelayedrewardofthepostoperativeinsulargliomapatientsindelaydiscounting AT bowenxue reducedsensitivitytodelayedtimeanddelayedrewardofthepostoperativeinsulargliomapatientsindelaydiscounting AT zhenyeli reducedsensitivitytodelayedtimeanddelayedrewardofthepostoperativeinsulargliomapatientsindelaydiscounting AT chuanshengchen reducedsensitivitytodelayedtimeanddelayedrewardofthepostoperativeinsulargliomapatientsindelaydiscounting AT shengjunsun reducedsensitivitytodelayedtimeanddelayedrewardofthepostoperativeinsulargliomapatientsindelaydiscounting AT yazhuozhang reducedsensitivitytodelayedtimeanddelayedrewardofthepostoperativeinsulargliomapatientsindelaydiscounting AT zongganghou reducedsensitivitytodelayedtimeanddelayedrewardofthepostoperativeinsulargliomapatientsindelaydiscounting AT jianxie reducedsensitivitytodelayedtimeanddelayedrewardofthepostoperativeinsulargliomapatientsindelaydiscounting |
| _version_ |
1718373007682961408 |