Nutritional status at diagnosis among children with cancer referred to a nutritional service in Brazil

Introduction: Children and adolescents with cancer are particularly vulnerable to malnutrition and require special attention on nutritional assessment. An adequate nutritional status during treatment is essential in reducing morbidity and mortality, being a modifiable risk factor for clinical outcom...

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Autores principales:	Karina Viani, Ronald D. Barr, Vicente Odone Filho, Elena J. Ladas
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Nutritional status Child Adolescent Neoplasms/metabolism Brazil Diseases of the blood and blood-forming organs RC633-647.5
Acceso en línea:	https://doaj.org/article/f8842576ab4a4afd90a59c02250c8e68
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spelling	oai:doaj.org-article:f8842576ab4a4afd90a59c02250c8e682021-11-04T04:36:50ZNutritional status at diagnosis among children with cancer referred to a nutritional service in Brazil2531-137910.1016/j.htct.2020.04.008https://doaj.org/article/f8842576ab4a4afd90a59c02250c8e682021-10-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2531137920300699https://doaj.org/toc/2531-1379Introduction: Children and adolescents with cancer are particularly vulnerable to malnutrition and require special attention on nutritional assessment. An adequate nutritional status during treatment is essential in reducing morbidity and mortality, being a modifiable risk factor for clinical outcomes. This study aims to determine the nutritional status of pediatric patients with cancer assessed by the nutrition team at diagnosis and evaluate its association with the overall survival. Method: This is a retrospective cross-sectional study of patients at the time of cancer diagnosis who had nutritional assessments when hospitalized or referred to the nutrition outpatient clinic. Nutritional status was classified by the mid-upper arm circumference (MUAC) and body mass index for age z-score (zBMI/A). The Cox regression analysis was used to determine the association between the nutritional status and overall survival, adjusting for gender, tumor group and age. Results: The study included 366 patients. The prevalence of undernutrition varied from 8 to 23% and overweight, from 5 to 20%. The MUAC identified more children as undernourished than the zBMI/A in patients with solid and hematological tumors. There was no significant difference in the overall survival by malnutrition classified by the zBMI/A (p =  0.1507) or MUAC (p =  0.8135). When adjusted for gender, tumor group and age, the nutritional status classification by the zBMI/A (hazard ratio [HR], 1.27; 95% confidence interval [CI], 0.88–1.83; p =  0.209) and MUAC (HR, 0.94; 95% CI, 0.61–1.44; p =  0.773) did not impact overall survival. Conclusion: The nutritional status at diagnosis did not significantly impact the overall survival, which suggests there may have been a protective effect by successful nutritional intervention during the subsequent care.Karina VianiRonald D. BarrVicente Odone FilhoElena J. LadasElsevierarticleNutritional statusChildAdolescentNeoplasms/metabolismBrazilDiseases of the blood and blood-forming organsRC633-647.5ENHematology, Transfusion and Cell Therapy, Vol 43, Iss 4, Pp 389-395 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Nutritional status Child Adolescent Neoplasms/metabolism Brazil Diseases of the blood and blood-forming organs RC633-647.5
spellingShingle	Nutritional status Child Adolescent Neoplasms/metabolism Brazil Diseases of the blood and blood-forming organs RC633-647.5 Karina Viani Ronald D. Barr Vicente Odone Filho Elena J. Ladas Nutritional status at diagnosis among children with cancer referred to a nutritional service in Brazil
description	Introduction: Children and adolescents with cancer are particularly vulnerable to malnutrition and require special attention on nutritional assessment. An adequate nutritional status during treatment is essential in reducing morbidity and mortality, being a modifiable risk factor for clinical outcomes. This study aims to determine the nutritional status of pediatric patients with cancer assessed by the nutrition team at diagnosis and evaluate its association with the overall survival. Method: This is a retrospective cross-sectional study of patients at the time of cancer diagnosis who had nutritional assessments when hospitalized or referred to the nutrition outpatient clinic. Nutritional status was classified by the mid-upper arm circumference (MUAC) and body mass index for age z-score (zBMI/A). The Cox regression analysis was used to determine the association between the nutritional status and overall survival, adjusting for gender, tumor group and age. Results: The study included 366 patients. The prevalence of undernutrition varied from 8 to 23% and overweight, from 5 to 20%. The MUAC identified more children as undernourished than the zBMI/A in patients with solid and hematological tumors. There was no significant difference in the overall survival by malnutrition classified by the zBMI/A (p =  0.1507) or MUAC (p =  0.8135). When adjusted for gender, tumor group and age, the nutritional status classification by the zBMI/A (hazard ratio [HR], 1.27; 95% confidence interval [CI], 0.88–1.83; p =  0.209) and MUAC (HR, 0.94; 95% CI, 0.61–1.44; p =  0.773) did not impact overall survival. Conclusion: The nutritional status at diagnosis did not significantly impact the overall survival, which suggests there may have been a protective effect by successful nutritional intervention during the subsequent care.
format	article
author	Karina Viani Ronald D. Barr Vicente Odone Filho Elena J. Ladas
author_facet	Karina Viani Ronald D. Barr Vicente Odone Filho Elena J. Ladas
author_sort	Karina Viani
title	Nutritional status at diagnosis among children with cancer referred to a nutritional service in Brazil
title_short	Nutritional status at diagnosis among children with cancer referred to a nutritional service in Brazil
title_full	Nutritional status at diagnosis among children with cancer referred to a nutritional service in Brazil
title_fullStr	Nutritional status at diagnosis among children with cancer referred to a nutritional service in Brazil
title_full_unstemmed	Nutritional status at diagnosis among children with cancer referred to a nutritional service in Brazil
title_sort	nutritional status at diagnosis among children with cancer referred to a nutritional service in brazil
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/f8842576ab4a4afd90a59c02250c8e68
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Nutritional status at diagnosis among children with cancer referred to a nutritional service in Brazil

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