STAT1 gain-of-function heterozygous cell models reveal diverse interferon-signature gene transcriptional responses

STAT1 gain-of-function heterozygous cell models reveal diverse interferon-signature gene transcriptional responses

Abstract Signal transducer and activator of transcription 1 (STAT1) gain-of-function (GOF) is an autosomal dominant immune disorder marked by wide infectious predisposition, autoimmunity, vascular disease, and malignancy. Its molecular hallmark, elevated phospho-STAT1 (pSTAT1) following interferon (...

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Autores principales: Ori Scott, Kyle Lindsay, Steven Erwood, Antonio Mollica, Chaim M. Roifman, Ronald D. Cohn, Evgueni A. Ivakine
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Genetics
QH426-470
Acceso en línea:https://doaj.org/article/f8847bc7541a4ab68fbd2ae0e0ec203f
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