NBTXR3 Radiotherapy-Activated Functionalized Hafnium Oxide Nanoparticles Show Efficient Antitumor Effects Across a Large Panel of Human Cancer Models

Ping Zhang,1 Julie Marill,1 Audrey Darmon,1 Naeemunnisa Mohamed Anesary,1 Bo Lu,2 Sébastien Paris1 1Nanobiotix, Paris, France; 2Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA, 19107, USACorrespondence: Sébastien ParisNanobiotix, 60 rue de Wattig...

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Autores principales:	Zhang P, Marill J, Darmon A, Mohamed Anesary N, Lu B, Paris S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	radiotherapy radioenhancer nanoparticle nbtxr3 cancer Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/f884981327a745a3b818c94e208a4da7
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spelling	oai:doaj.org-article:f884981327a745a3b818c94e208a4da72021-12-02T15:41:25ZNBTXR3 Radiotherapy-Activated Functionalized Hafnium Oxide Nanoparticles Show Efficient Antitumor Effects Across a Large Panel of Human Cancer Models1178-2013https://doaj.org/article/f884981327a745a3b818c94e208a4da72021-04-01T00:00:00Zhttps://www.dovepress.com/nbtxr3-radiotherapy-activated-functionalized-hafnium-oxide-nanoparticl-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Ping Zhang,1 Julie Marill,1 Audrey Darmon,1 Naeemunnisa Mohamed Anesary,1 Bo Lu,2 Sébastien Paris1 1Nanobiotix, Paris, France; 2Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA, 19107, USACorrespondence: Sébastien ParisNanobiotix, 60 rue de Wattignies, Paris, 75012, FranceTel +33 1 75 44 72 33Fax +33 1 40 26 04 44Email sebastien.paris@nanobiotix.comPurpose: The side effects of radiotherapy induced on healthy tissue limit its use. To overcome this issue and fully exploit the potential of radiotherapy to treat cancers, the first-in-class radioenhancer NBTXR3 (functionalized hafnium oxide nanoparticles) has been designed to amplify the effects of radiotherapy.Patients and Methods: Thanks to its physical mode of action, NBTXR3 has the potential to be used to treat any type of solid tumor. Here we demonstrate that NBTXR3 can be used to treat a wide variety of solid cancers. For this, we evaluated different parameters on a large panel of human cancer models, such as nanoparticle endocytosis, in vitro cell death induction, dispersion, and retention of NBTXR3 in the tumor tissue and tumor growth control.Results: Whatever the model considered, we show that NBTXR3 was internalized by cancer cells and persisted within the tumors throughout radiotherapy treatment. NBTXR3 activated by radiotherapy was also more effective in destroying cancer cells and in controlling tumor growth than radiotherapy alone. Beyond the effects of NBTXR3 as single agent, we show that the antitumor efficacy of cisplatin-based chemoradiotherapy treatment was improved when combined with NBTXR3.Conclusion: These data support that NBTXR3 could be universally used to treat solid cancers when radiotherapy is indicated, opening promising new therapeutic perspectives of treatment for the benefit of many patients.Keywords: radiotherapy, radioenhancer, nanoparticle, NBTXR3, cancerZhang PMarill JDarmon AMohamed Anesary NLu BParis SDove Medical Pressarticleradiotherapyradioenhancernanoparticlenbtxr3cancerMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 16, Pp 2761-2773 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	radiotherapy radioenhancer nanoparticle nbtxr3 cancer Medicine (General) R5-920
spellingShingle	radiotherapy radioenhancer nanoparticle nbtxr3 cancer Medicine (General) R5-920 Zhang P Marill J Darmon A Mohamed Anesary N Lu B Paris S NBTXR3 Radiotherapy-Activated Functionalized Hafnium Oxide Nanoparticles Show Efficient Antitumor Effects Across a Large Panel of Human Cancer Models
description	Ping Zhang,1 Julie Marill,1 Audrey Darmon,1 Naeemunnisa Mohamed Anesary,1 Bo Lu,2 Sébastien Paris1 1Nanobiotix, Paris, France; 2Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA, 19107, USACorrespondence: Sébastien ParisNanobiotix, 60 rue de Wattignies, Paris, 75012, FranceTel +33 1 75 44 72 33Fax +33 1 40 26 04 44Email sebastien.paris@nanobiotix.comPurpose: The side effects of radiotherapy induced on healthy tissue limit its use. To overcome this issue and fully exploit the potential of radiotherapy to treat cancers, the first-in-class radioenhancer NBTXR3 (functionalized hafnium oxide nanoparticles) has been designed to amplify the effects of radiotherapy.Patients and Methods: Thanks to its physical mode of action, NBTXR3 has the potential to be used to treat any type of solid tumor. Here we demonstrate that NBTXR3 can be used to treat a wide variety of solid cancers. For this, we evaluated different parameters on a large panel of human cancer models, such as nanoparticle endocytosis, in vitro cell death induction, dispersion, and retention of NBTXR3 in the tumor tissue and tumor growth control.Results: Whatever the model considered, we show that NBTXR3 was internalized by cancer cells and persisted within the tumors throughout radiotherapy treatment. NBTXR3 activated by radiotherapy was also more effective in destroying cancer cells and in controlling tumor growth than radiotherapy alone. Beyond the effects of NBTXR3 as single agent, we show that the antitumor efficacy of cisplatin-based chemoradiotherapy treatment was improved when combined with NBTXR3.Conclusion: These data support that NBTXR3 could be universally used to treat solid cancers when radiotherapy is indicated, opening promising new therapeutic perspectives of treatment for the benefit of many patients.Keywords: radiotherapy, radioenhancer, nanoparticle, NBTXR3, cancer
format	article
author	Zhang P Marill J Darmon A Mohamed Anesary N Lu B Paris S
author_facet	Zhang P Marill J Darmon A Mohamed Anesary N Lu B Paris S
author_sort	Zhang P
title	NBTXR3 Radiotherapy-Activated Functionalized Hafnium Oxide Nanoparticles Show Efficient Antitumor Effects Across a Large Panel of Human Cancer Models
title_short	NBTXR3 Radiotherapy-Activated Functionalized Hafnium Oxide Nanoparticles Show Efficient Antitumor Effects Across a Large Panel of Human Cancer Models
title_full	NBTXR3 Radiotherapy-Activated Functionalized Hafnium Oxide Nanoparticles Show Efficient Antitumor Effects Across a Large Panel of Human Cancer Models
title_fullStr	NBTXR3 Radiotherapy-Activated Functionalized Hafnium Oxide Nanoparticles Show Efficient Antitumor Effects Across a Large Panel of Human Cancer Models
title_full_unstemmed	NBTXR3 Radiotherapy-Activated Functionalized Hafnium Oxide Nanoparticles Show Efficient Antitumor Effects Across a Large Panel of Human Cancer Models
title_sort	nbtxr3 radiotherapy-activated functionalized hafnium oxide nanoparticles show efficient antitumor effects across a large panel of human cancer models
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/f884981327a745a3b818c94e208a4da7
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NBTXR3 Radiotherapy-Activated Functionalized Hafnium Oxide Nanoparticles Show Efficient Antitumor Effects Across a Large Panel of Human Cancer Models

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