A case of Candida auris candidemia in Xiamen, China, and a comparative analysis of clinical isolates in China

The recently emerged fungal pathogen Candida auris often displays resistance to one or more antifungal drugs. Its infections have been identified in at least 40 countries on six continents to date. Here we report a case of C. auris candidemia in a patient in Xiamen, a city in south China. We also re...

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Autores principales:	Jian Bing, Sijia Wang, Heping Xu, Shuru Fan, Han Du, Clarissa J. Nobile, Guanghua Huang
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	candida auris antifungal resistance mating type locus virulence morphology Biology (General) QH301-705.5 Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/f888500eb1c34da3b8f1334df745aa3f
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spelling	oai:doaj.org-article:f888500eb1c34da3b8f1334df745aa3f2021-11-04T15:00:43ZA case of Candida auris candidemia in Xiamen, China, and a comparative analysis of clinical isolates in China2150-12032150-121110.1080/21501203.2021.1994479https://doaj.org/article/f888500eb1c34da3b8f1334df745aa3f2021-10-01T00:00:00Zhttp://dx.doi.org/10.1080/21501203.2021.1994479https://doaj.org/toc/2150-1203https://doaj.org/toc/2150-1211The recently emerged fungal pathogen Candida auris often displays resistance to one or more antifungal drugs. Its infections have been identified in at least 40 countries on six continents to date. Here we report a case of C. auris candidemia in a patient in Xiamen, a city in south China. We also review currently reported cases of C. auris infection in China and compare the genetic and biological features of C. auris strains isolated from this country. Our phylogenetic analysis indicates that there are at least two C. auris genetic clades present in China (the South African clade and the south Asian clade) that display opposite mating type loci (one is MTLa and the other is MTLα). We also found that there are several distinct features among the clinical isolates studied, including the expression of virulence factors, antifungal susceptibilities, and cellular morphologies, and that these features could be associated with the mating-type of the isolate. For example, C. auris MTLa isolates generally secreted higher levels of secreted aspartyl proteases (Saps) at ambient environmental temperatures. Taken together, this study demonstrates that C. auris clinical isolates from China exhibit diversity in both biological and genetic features.Jian BingSijia WangHeping XuShuru FanHan DuClarissa J. NobileGuanghua HuangTaylor & Francis Grouparticlecandida aurisantifungal resistancemating type locusvirulencemorphologyBiology (General)QH301-705.5MicrobiologyQR1-502ENMycology, Vol 0, Iss 0, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	candida auris antifungal resistance mating type locus virulence morphology Biology (General) QH301-705.5 Microbiology QR1-502
spellingShingle	candida auris antifungal resistance mating type locus virulence morphology Biology (General) QH301-705.5 Microbiology QR1-502 Jian Bing Sijia Wang Heping Xu Shuru Fan Han Du Clarissa J. Nobile Guanghua Huang A case of Candida auris candidemia in Xiamen, China, and a comparative analysis of clinical isolates in China
description	The recently emerged fungal pathogen Candida auris often displays resistance to one or more antifungal drugs. Its infections have been identified in at least 40 countries on six continents to date. Here we report a case of C. auris candidemia in a patient in Xiamen, a city in south China. We also review currently reported cases of C. auris infection in China and compare the genetic and biological features of C. auris strains isolated from this country. Our phylogenetic analysis indicates that there are at least two C. auris genetic clades present in China (the South African clade and the south Asian clade) that display opposite mating type loci (one is MTLa and the other is MTLα). We also found that there are several distinct features among the clinical isolates studied, including the expression of virulence factors, antifungal susceptibilities, and cellular morphologies, and that these features could be associated with the mating-type of the isolate. For example, C. auris MTLa isolates generally secreted higher levels of secreted aspartyl proteases (Saps) at ambient environmental temperatures. Taken together, this study demonstrates that C. auris clinical isolates from China exhibit diversity in both biological and genetic features.
format	article
author	Jian Bing Sijia Wang Heping Xu Shuru Fan Han Du Clarissa J. Nobile Guanghua Huang
author_facet	Jian Bing Sijia Wang Heping Xu Shuru Fan Han Du Clarissa J. Nobile Guanghua Huang
author_sort	Jian Bing
title	A case of Candida auris candidemia in Xiamen, China, and a comparative analysis of clinical isolates in China
title_short	A case of Candida auris candidemia in Xiamen, China, and a comparative analysis of clinical isolates in China
title_full	A case of Candida auris candidemia in Xiamen, China, and a comparative analysis of clinical isolates in China
title_fullStr	A case of Candida auris candidemia in Xiamen, China, and a comparative analysis of clinical isolates in China
title_full_unstemmed	A case of Candida auris candidemia in Xiamen, China, and a comparative analysis of clinical isolates in China
title_sort	case of candida auris candidemia in xiamen, china, and a comparative analysis of clinical isolates in china
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/f888500eb1c34da3b8f1334df745aa3f
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A case of Candida auris candidemia in Xiamen, China, and a comparative analysis of clinical isolates in China

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