PAK proteins and YAP-1 signalling downstream of integrin beta-1 in myofibroblasts promote liver fibrosis

Antifibrotic therapies that target myofibroblast activation are needed to treat chronic liver disease. Here the authors identify an axis of integrin beta-1 expression and Yap-1 and Pak protein signalling that can be interfered with to inhibit myofibroblast function and liver fibrosis in vivo.

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Autores principales:	Katherine Martin, James Pritchett, Jessica Llewellyn, Aoibheann F. Mullan, Varinder S. Athwal, Ross Dobie, Emma Harvey, Leo Zeef, Stuart Farrow, Charles Streuli, Neil C. Henderson, Scott L. Friedman, Neil A. Hanley, Karen Piper Hanley
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f88a909827dd4238bbf8364f30631af2
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spelling	oai:doaj.org-article:f88a909827dd4238bbf8364f30631af22021-12-02T17:31:33ZPAK proteins and YAP-1 signalling downstream of integrin beta-1 in myofibroblasts promote liver fibrosis10.1038/ncomms125022041-1723https://doaj.org/article/f88a909827dd4238bbf8364f30631af22016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12502https://doaj.org/toc/2041-1723Antifibrotic therapies that target myofibroblast activation are needed to treat chronic liver disease. Here the authors identify an axis of integrin beta-1 expression and Yap-1 and Pak protein signalling that can be interfered with to inhibit myofibroblast function and liver fibrosis in vivo.Katherine MartinJames PritchettJessica LlewellynAoibheann F. MullanVarinder S. AthwalRoss DobieEmma HarveyLeo ZeefStuart FarrowCharles StreuliNeil C. HendersonScott L. FriedmanNeil A. HanleyKaren Piper HanleyNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Katherine Martin James Pritchett Jessica Llewellyn Aoibheann F. Mullan Varinder S. Athwal Ross Dobie Emma Harvey Leo Zeef Stuart Farrow Charles Streuli Neil C. Henderson Scott L. Friedman Neil A. Hanley Karen Piper Hanley PAK proteins and YAP-1 signalling downstream of integrin beta-1 in myofibroblasts promote liver fibrosis
description	Antifibrotic therapies that target myofibroblast activation are needed to treat chronic liver disease. Here the authors identify an axis of integrin beta-1 expression and Yap-1 and Pak protein signalling that can be interfered with to inhibit myofibroblast function and liver fibrosis in vivo.
format	article
author	Katherine Martin James Pritchett Jessica Llewellyn Aoibheann F. Mullan Varinder S. Athwal Ross Dobie Emma Harvey Leo Zeef Stuart Farrow Charles Streuli Neil C. Henderson Scott L. Friedman Neil A. Hanley Karen Piper Hanley
author_facet	Katherine Martin James Pritchett Jessica Llewellyn Aoibheann F. Mullan Varinder S. Athwal Ross Dobie Emma Harvey Leo Zeef Stuart Farrow Charles Streuli Neil C. Henderson Scott L. Friedman Neil A. Hanley Karen Piper Hanley
author_sort	Katherine Martin
title	PAK proteins and YAP-1 signalling downstream of integrin beta-1 in myofibroblasts promote liver fibrosis
title_short	PAK proteins and YAP-1 signalling downstream of integrin beta-1 in myofibroblasts promote liver fibrosis
title_full	PAK proteins and YAP-1 signalling downstream of integrin beta-1 in myofibroblasts promote liver fibrosis
title_fullStr	PAK proteins and YAP-1 signalling downstream of integrin beta-1 in myofibroblasts promote liver fibrosis
title_full_unstemmed	PAK proteins and YAP-1 signalling downstream of integrin beta-1 in myofibroblasts promote liver fibrosis
title_sort	pak proteins and yap-1 signalling downstream of integrin beta-1 in myofibroblasts promote liver fibrosis
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/f88a909827dd4238bbf8364f30631af2
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PAK proteins and YAP-1 signalling downstream of integrin beta-1 in myofibroblasts promote liver fibrosis

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