SARS-CoV-2 hijacks folate and one-carbon metabolism for viral replication
Viruses rely on host metabolism for replication. Here, the authors perform transcriptional and metabolomic analyses at 8 hours after SARS-CoV-2 infection and find that the virus alters host folate and one-carbon metabolism at a post-transcriptional level.
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Nature Portfolio
2021
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oai:doaj.org-article:f88a9b0dc0a044b0976adf1dcbbff5ba2021-12-02T13:17:53ZSARS-CoV-2 hijacks folate and one-carbon metabolism for viral replication10.1038/s41467-021-21903-z2041-1723https://doaj.org/article/f88a9b0dc0a044b0976adf1dcbbff5ba2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21903-zhttps://doaj.org/toc/2041-1723Viruses rely on host metabolism for replication. Here, the authors perform transcriptional and metabolomic analyses at 8 hours after SARS-CoV-2 infection and find that the virus alters host folate and one-carbon metabolism at a post-transcriptional level.Yuchen ZhangRui GuoSharon H. KimHardik ShahShuting ZhangJin Hua LiangYing FangMatteo GentiliColin N. O’ LearySteven J. ElledgeDeborah T. HungVamsi K. MoothaBenjamin E. GewurzNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021) |
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DOAJ |
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EN |
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Science Q |
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Science Q Yuchen Zhang Rui Guo Sharon H. Kim Hardik Shah Shuting Zhang Jin Hua Liang Ying Fang Matteo Gentili Colin N. O’ Leary Steven J. Elledge Deborah T. Hung Vamsi K. Mootha Benjamin E. Gewurz SARS-CoV-2 hijacks folate and one-carbon metabolism for viral replication |
description |
Viruses rely on host metabolism for replication. Here, the authors perform transcriptional and metabolomic analyses at 8 hours after SARS-CoV-2 infection and find that the virus alters host folate and one-carbon metabolism at a post-transcriptional level. |
format |
article |
author |
Yuchen Zhang Rui Guo Sharon H. Kim Hardik Shah Shuting Zhang Jin Hua Liang Ying Fang Matteo Gentili Colin N. O’ Leary Steven J. Elledge Deborah T. Hung Vamsi K. Mootha Benjamin E. Gewurz |
author_facet |
Yuchen Zhang Rui Guo Sharon H. Kim Hardik Shah Shuting Zhang Jin Hua Liang Ying Fang Matteo Gentili Colin N. O’ Leary Steven J. Elledge Deborah T. Hung Vamsi K. Mootha Benjamin E. Gewurz |
author_sort |
Yuchen Zhang |
title |
SARS-CoV-2 hijacks folate and one-carbon metabolism for viral replication |
title_short |
SARS-CoV-2 hijacks folate and one-carbon metabolism for viral replication |
title_full |
SARS-CoV-2 hijacks folate and one-carbon metabolism for viral replication |
title_fullStr |
SARS-CoV-2 hijacks folate and one-carbon metabolism for viral replication |
title_full_unstemmed |
SARS-CoV-2 hijacks folate and one-carbon metabolism for viral replication |
title_sort |
sars-cov-2 hijacks folate and one-carbon metabolism for viral replication |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/f88a9b0dc0a044b0976adf1dcbbff5ba |
work_keys_str_mv |
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1718393368141103104 |