SARS-CoV-2 hijacks folate and one-carbon metabolism for viral replication

Viruses rely on host metabolism for replication. Here, the authors perform transcriptional and metabolomic analyses at 8 hours after SARS-CoV-2 infection and find that the virus alters host folate and one-carbon metabolism at a post-transcriptional level.

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Auteurs principaux:	Yuchen Zhang, Rui Guo, Sharon H. Kim, Hardik Shah, Shuting Zhang, Jin Hua Liang, Ying Fang, Matteo Gentili, Colin N. O’ Leary, Steven J. Elledge, Deborah T. Hung, Vamsi K. Mootha, Benjamin E. Gewurz
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2021
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/f88a9b0dc0a044b0976adf1dcbbff5ba
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spelling	oai:doaj.org-article:f88a9b0dc0a044b0976adf1dcbbff5ba2021-12-02T13:17:53ZSARS-CoV-2 hijacks folate and one-carbon metabolism for viral replication10.1038/s41467-021-21903-z2041-1723https://doaj.org/article/f88a9b0dc0a044b0976adf1dcbbff5ba2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21903-zhttps://doaj.org/toc/2041-1723Viruses rely on host metabolism for replication. Here, the authors perform transcriptional and metabolomic analyses at 8 hours after SARS-CoV-2 infection and find that the virus alters host folate and one-carbon metabolism at a post-transcriptional level.Yuchen ZhangRui GuoSharon H. KimHardik ShahShuting ZhangJin Hua LiangYing FangMatteo GentiliColin N. O’ LearySteven J. ElledgeDeborah T. HungVamsi K. MoothaBenjamin E. GewurzNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yuchen Zhang Rui Guo Sharon H. Kim Hardik Shah Shuting Zhang Jin Hua Liang Ying Fang Matteo Gentili Colin N. O’ Leary Steven J. Elledge Deborah T. Hung Vamsi K. Mootha Benjamin E. Gewurz SARS-CoV-2 hijacks folate and one-carbon metabolism for viral replication
description	Viruses rely on host metabolism for replication. Here, the authors perform transcriptional and metabolomic analyses at 8 hours after SARS-CoV-2 infection and find that the virus alters host folate and one-carbon metabolism at a post-transcriptional level.
format	article
author	Yuchen Zhang Rui Guo Sharon H. Kim Hardik Shah Shuting Zhang Jin Hua Liang Ying Fang Matteo Gentili Colin N. O’ Leary Steven J. Elledge Deborah T. Hung Vamsi K. Mootha Benjamin E. Gewurz
author_facet	Yuchen Zhang Rui Guo Sharon H. Kim Hardik Shah Shuting Zhang Jin Hua Liang Ying Fang Matteo Gentili Colin N. O’ Leary Steven J. Elledge Deborah T. Hung Vamsi K. Mootha Benjamin E. Gewurz
author_sort	Yuchen Zhang
title	SARS-CoV-2 hijacks folate and one-carbon metabolism for viral replication
title_short	SARS-CoV-2 hijacks folate and one-carbon metabolism for viral replication
title_full	SARS-CoV-2 hijacks folate and one-carbon metabolism for viral replication
title_fullStr	SARS-CoV-2 hijacks folate and one-carbon metabolism for viral replication
title_full_unstemmed	SARS-CoV-2 hijacks folate and one-carbon metabolism for viral replication
title_sort	sars-cov-2 hijacks folate and one-carbon metabolism for viral replication
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f88a9b0dc0a044b0976adf1dcbbff5ba
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SARS-CoV-2 hijacks folate and one-carbon metabolism for viral replication

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