Five-year results of photodynamic therapy with verteporfin for Japanese patients with neovascular age-related macular degeneration

Takashi Tsuchihashi, Keisuke Mori, Kazuhiro Ueyama, Shin Yoneya Department of Ophthalmology, Saitama Medical University, Iruma, Saitama, Japan Purpose: To describe the treatment outcome of photodynamic therapy (PDT) in Japanese patients with age-related macular degeneration (AMD) followed for 5 year...

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Autores principales:	Tsuchihashi T, Mori K, Ueyama K, Yoneya S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/f891854e2cc94cc7b638f11874895025
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spelling	oai:doaj.org-article:f891854e2cc94cc7b638f118748950252021-12-02T06:01:19ZFive-year results of photodynamic therapy with verteporfin for Japanese patients with neovascular age-related macular degeneration1177-54671177-5483https://doaj.org/article/f891854e2cc94cc7b638f118748950252013-03-01T00:00:00Zhttp://www.dovepress.com/five-year-results-of-photodynamic-therapy-with-verteporfin-for-japanes-a12596https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Takashi Tsuchihashi, Keisuke Mori, Kazuhiro Ueyama, Shin Yoneya Department of Ophthalmology, Saitama Medical University, Iruma, Saitama, Japan Purpose: To describe the treatment outcome of photodynamic therapy (PDT) in Japanese patients with age-related macular degeneration (AMD) followed for 5 years. Patients and methods: We retrospectively reviewed clinical charts of 51 patients with AMD. Thirty-one eyes of typical AMD (tAMD) and 20 eyes of polypoidal choroidal vasculopathy (PCV) were evaluated. Results: The mean logarithm of the minimum angle of resolution (logMAR) vision of all AMD patients was 0.807 at the baseline examination and 0.937 at the 5 year examination. Mean visual acuity letter score loss is similar between patients with tAMD (−7.25) and with PCV (−5.36) at the month 60 examination. The patients with lesions of classic choroidal neovascularization (CNV) had 10.0 letters loss, but the patients with lesions of occult CNV had only 1.43 letters loss. The number of retreatments peaked in year 1 and declined immediately for patients with tAMD, but patients with PCV had significantly more frequent retreatments in the years 3 and 4 than patients with tAMD (P = 1.48 × 10−2, 5.96 × 10−3, respectively). Conclusion: Visual outcomes in patients with Japanese patients with AMD treated with PDT after 5-year follow up were worse than that in short-term follow up reported previously. In addition, the difference in visual prognosis between tAMD and PCV was not demonstrated after long-term follow-up. Keywords: photodynamic therapy, age-related macular degeneration, polypoidal choroidal vasculopathy, visual outcomesTsuchihashi TMori KUeyama KYoneya SDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2013, Iss default, Pp 615-620 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Tsuchihashi T Mori K Ueyama K Yoneya S Five-year results of photodynamic therapy with verteporfin for Japanese patients with neovascular age-related macular degeneration
description	Takashi Tsuchihashi, Keisuke Mori, Kazuhiro Ueyama, Shin Yoneya Department of Ophthalmology, Saitama Medical University, Iruma, Saitama, Japan Purpose: To describe the treatment outcome of photodynamic therapy (PDT) in Japanese patients with age-related macular degeneration (AMD) followed for 5 years. Patients and methods: We retrospectively reviewed clinical charts of 51 patients with AMD. Thirty-one eyes of typical AMD (tAMD) and 20 eyes of polypoidal choroidal vasculopathy (PCV) were evaluated. Results: The mean logarithm of the minimum angle of resolution (logMAR) vision of all AMD patients was 0.807 at the baseline examination and 0.937 at the 5 year examination. Mean visual acuity letter score loss is similar between patients with tAMD (−7.25) and with PCV (−5.36) at the month 60 examination. The patients with lesions of classic choroidal neovascularization (CNV) had 10.0 letters loss, but the patients with lesions of occult CNV had only 1.43 letters loss. The number of retreatments peaked in year 1 and declined immediately for patients with tAMD, but patients with PCV had significantly more frequent retreatments in the years 3 and 4 than patients with tAMD (P = 1.48 × 10−2, 5.96 × 10−3, respectively). Conclusion: Visual outcomes in patients with Japanese patients with AMD treated with PDT after 5-year follow up were worse than that in short-term follow up reported previously. In addition, the difference in visual prognosis between tAMD and PCV was not demonstrated after long-term follow-up. Keywords: photodynamic therapy, age-related macular degeneration, polypoidal choroidal vasculopathy, visual outcomes
format	article
author	Tsuchihashi T Mori K Ueyama K Yoneya S
author_facet	Tsuchihashi T Mori K Ueyama K Yoneya S
author_sort	Tsuchihashi T
title	Five-year results of photodynamic therapy with verteporfin for Japanese patients with neovascular age-related macular degeneration
title_short	Five-year results of photodynamic therapy with verteporfin for Japanese patients with neovascular age-related macular degeneration
title_full	Five-year results of photodynamic therapy with verteporfin for Japanese patients with neovascular age-related macular degeneration
title_fullStr	Five-year results of photodynamic therapy with verteporfin for Japanese patients with neovascular age-related macular degeneration
title_full_unstemmed	Five-year results of photodynamic therapy with verteporfin for Japanese patients with neovascular age-related macular degeneration
title_sort	five-year results of photodynamic therapy with verteporfin for japanese patients with neovascular age-related macular degeneration
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/f891854e2cc94cc7b638f11874895025
work_keys_str_mv	AT tsuchihashit fiveyearresultsofphotodynamictherapywithverteporfinforjapanesepatientswithneovascularagerelatedmaculardegeneration AT morik fiveyearresultsofphotodynamictherapywithverteporfinforjapanesepatientswithneovascularagerelatedmaculardegeneration AT ueyamak fiveyearresultsofphotodynamictherapywithverteporfinforjapanesepatientswithneovascularagerelatedmaculardegeneration AT yoneyas fiveyearresultsofphotodynamictherapywithverteporfinforjapanesepatientswithneovascularagerelatedmaculardegeneration
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Five-year results of photodynamic therapy with verteporfin for Japanese patients with neovascular age-related macular degeneration

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