Non-invasive imaging of disrupted protein homeostasis induced by proteasome inhibitor treatment using chemical exchange saturation transfer MRI

Abstract Proteasome inhibitors (PIs) are now standard of care for several cancers, and noninvasive biomarkers of treatment response are critically required for early patient stratification and treatment personalization. The present study evaluated whether chemical exchange (CEST) magnetic resonance...

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Auteurs principaux: Yanan Zhu, Rajiv Ramasawmy, Sean Peter Johnson, Valerie Taylor, Alasdair Gibb, R. Barbara Pedley, Nibedita Chattopadhyay, Mark F. Lythgoe, Xavier Golay, Daniel Bradley, Simon Walker-Samuel
Format: article
Langue:EN
Publié: Nature Portfolio 2018
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Accès en ligne:https://doaj.org/article/f8952b03910249259df62b0f5a1bc8a4
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