A genetic network that suppresses genome rearrangements in Saccharomyces cerevisiae and contains defects in cancers

Here, Richard Kolodner and colleagues use assays in Saccharomyces cerevisiaeto identify 182 genetic modifiers of gross chromosomal rearrangements (GCRs). They also compared these Genome Instability Suppressing (GIS) genes and pathways in human cancer genome, and found many ovarian and colorectal can...

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Autores principales:	Christopher D. Putnam, Anjana Srivatsan, Rahul V. Nene, Sandra L. Martinez, Sarah P. Clotfelter, Sara N. Bell, Steven B. Somach, Jorge E.S. de Souza, André F. Fonseca, Sandro J. de Souza, Richard D. Kolodner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f89534c401544c92a42a58da6b4da8ce
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spelling	oai:doaj.org-article:f89534c401544c92a42a58da6b4da8ce2021-12-02T14:39:50ZA genetic network that suppresses genome rearrangements in Saccharomyces cerevisiae and contains defects in cancers10.1038/ncomms112562041-1723https://doaj.org/article/f89534c401544c92a42a58da6b4da8ce2016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11256https://doaj.org/toc/2041-1723Here, Richard Kolodner and colleagues use assays in Saccharomyces cerevisiaeto identify 182 genetic modifiers of gross chromosomal rearrangements (GCRs). They also compared these Genome Instability Suppressing (GIS) genes and pathways in human cancer genome, and found many ovarian and colorectal cancer cases have alterations to GIS pathways.Christopher D. PutnamAnjana SrivatsanRahul V. NeneSandra L. MartinezSarah P. ClotfelterSara N. BellSteven B. SomachJorge E.S. de SouzaAndré F. FonsecaSandro J. de SouzaRichard D. KolodnerNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Christopher D. Putnam Anjana Srivatsan Rahul V. Nene Sandra L. Martinez Sarah P. Clotfelter Sara N. Bell Steven B. Somach Jorge E.S. de Souza André F. Fonseca Sandro J. de Souza Richard D. Kolodner A genetic network that suppresses genome rearrangements in Saccharomyces cerevisiae and contains defects in cancers
description	Here, Richard Kolodner and colleagues use assays in Saccharomyces cerevisiaeto identify 182 genetic modifiers of gross chromosomal rearrangements (GCRs). They also compared these Genome Instability Suppressing (GIS) genes and pathways in human cancer genome, and found many ovarian and colorectal cancer cases have alterations to GIS pathways.
format	article
author	Christopher D. Putnam Anjana Srivatsan Rahul V. Nene Sandra L. Martinez Sarah P. Clotfelter Sara N. Bell Steven B. Somach Jorge E.S. de Souza André F. Fonseca Sandro J. de Souza Richard D. Kolodner
author_facet	Christopher D. Putnam Anjana Srivatsan Rahul V. Nene Sandra L. Martinez Sarah P. Clotfelter Sara N. Bell Steven B. Somach Jorge E.S. de Souza André F. Fonseca Sandro J. de Souza Richard D. Kolodner
author_sort	Christopher D. Putnam
title	A genetic network that suppresses genome rearrangements in Saccharomyces cerevisiae and contains defects in cancers
title_short	A genetic network that suppresses genome rearrangements in Saccharomyces cerevisiae and contains defects in cancers
title_full	A genetic network that suppresses genome rearrangements in Saccharomyces cerevisiae and contains defects in cancers
title_fullStr	A genetic network that suppresses genome rearrangements in Saccharomyces cerevisiae and contains defects in cancers
title_full_unstemmed	A genetic network that suppresses genome rearrangements in Saccharomyces cerevisiae and contains defects in cancers
title_sort	genetic network that suppresses genome rearrangements in saccharomyces cerevisiae and contains defects in cancers
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/f89534c401544c92a42a58da6b4da8ce
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A genetic network that suppresses genome rearrangements in Saccharomyces cerevisiae and contains defects in cancers

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