A genetic network that suppresses genome rearrangements in Saccharomyces cerevisiae and contains defects in cancers

A genetic network that suppresses genome rearrangements in Saccharomyces cerevisiae and contains defects in cancers

Here, Richard Kolodner and colleagues use assays in Saccharomyces cerevisiaeto identify 182 genetic modifiers of gross chromosomal rearrangements (GCRs). They also compared these Genome Instability Suppressing (GIS) genes and pathways in human cancer genome, and found many ovarian and colorectal can...

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Main Authors: Christopher D. Putnam, Anjana Srivatsan, Rahul V. Nene, Sandra L. Martinez, Sarah P. Clotfelter, Sara N. Bell, Steven B. Somach, Jorge E.S. de Souza, André F. Fonseca, Sandro J. de Souza, Richard D. Kolodner
Format: article
Language:EN
Published: Nature Portfolio 2016
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Science
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Online Access:https://doaj.org/article/f89534c401544c92a42a58da6b4da8ce
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https://doaj.org/article/f89534c401544c92a42a58da6b4da8ce

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