Selection signatures in worldwide sheep populations.

The diversity of populations in domestic species offers great opportunities to study genome response to selection. The recently published Sheep HapMap dataset is a great example of characterization of the world wide genetic diversity in sheep. In this study, we re-analyzed the Sheep HapMap dataset t...

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Autores principales: Maria-Ines Fariello, Bertrand Servin, Gwenola Tosser-Klopp, Rachel Rupp, Carole Moreno, International Sheep Genomics Consortium, Magali San Cristobal, Simon Boitard
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Publicado: Public Library of Science (PLoS) 2014
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Acceso en línea:https://doaj.org/article/f8984c53480a40e4bb130992e2710cf3
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spelling oai:doaj.org-article:f8984c53480a40e4bb130992e2710cf32021-11-25T06:04:29ZSelection signatures in worldwide sheep populations.1932-620310.1371/journal.pone.0103813https://doaj.org/article/f8984c53480a40e4bb130992e2710cf32014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25126940/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203The diversity of populations in domestic species offers great opportunities to study genome response to selection. The recently published Sheep HapMap dataset is a great example of characterization of the world wide genetic diversity in sheep. In this study, we re-analyzed the Sheep HapMap dataset to identify selection signatures in worldwide sheep populations. Compared to previous analyses, we made use of statistical methods that (i) take account of the hierarchical structure of sheep populations, (ii) make use of linkage disequilibrium information and (iii) focus specifically on either recent or older selection signatures. We show that this allows pinpointing several new selection signatures in the sheep genome and distinguishing those related to modern breeding objectives and to earlier post-domestication constraints. The newly identified regions, together with the ones previously identified, reveal the extensive genome response to selection on morphology, color and adaptation to new environments.Maria-Ines FarielloBertrand ServinGwenola Tosser-KloppRachel RuppCarole MorenoInternational Sheep Genomics ConsortiumMagali San CristobalSimon BoitardPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 8, p e103813 (2014)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Maria-Ines Fariello
Bertrand Servin
Gwenola Tosser-Klopp
Rachel Rupp
Carole Moreno
International Sheep Genomics Consortium
Magali San Cristobal
Simon Boitard
Selection signatures in worldwide sheep populations.
description The diversity of populations in domestic species offers great opportunities to study genome response to selection. The recently published Sheep HapMap dataset is a great example of characterization of the world wide genetic diversity in sheep. In this study, we re-analyzed the Sheep HapMap dataset to identify selection signatures in worldwide sheep populations. Compared to previous analyses, we made use of statistical methods that (i) take account of the hierarchical structure of sheep populations, (ii) make use of linkage disequilibrium information and (iii) focus specifically on either recent or older selection signatures. We show that this allows pinpointing several new selection signatures in the sheep genome and distinguishing those related to modern breeding objectives and to earlier post-domestication constraints. The newly identified regions, together with the ones previously identified, reveal the extensive genome response to selection on morphology, color and adaptation to new environments.
format article
author Maria-Ines Fariello
Bertrand Servin
Gwenola Tosser-Klopp
Rachel Rupp
Carole Moreno
International Sheep Genomics Consortium
Magali San Cristobal
Simon Boitard
author_facet Maria-Ines Fariello
Bertrand Servin
Gwenola Tosser-Klopp
Rachel Rupp
Carole Moreno
International Sheep Genomics Consortium
Magali San Cristobal
Simon Boitard
author_sort Maria-Ines Fariello
title Selection signatures in worldwide sheep populations.
title_short Selection signatures in worldwide sheep populations.
title_full Selection signatures in worldwide sheep populations.
title_fullStr Selection signatures in worldwide sheep populations.
title_full_unstemmed Selection signatures in worldwide sheep populations.
title_sort selection signatures in worldwide sheep populations.
publisher Public Library of Science (PLoS)
publishDate 2014
url https://doaj.org/article/f8984c53480a40e4bb130992e2710cf3
work_keys_str_mv AT mariainesfariello selectionsignaturesinworldwidesheeppopulations
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AT gwenolatosserklopp selectionsignaturesinworldwidesheeppopulations
AT rachelrupp selectionsignaturesinworldwidesheeppopulations
AT carolemoreno selectionsignaturesinworldwidesheeppopulations
AT internationalsheepgenomicsconsortium selectionsignaturesinworldwidesheeppopulations
AT magalisancristobal selectionsignaturesinworldwidesheeppopulations
AT simonboitard selectionsignaturesinworldwidesheeppopulations
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