Selection signatures in worldwide sheep populations.

The diversity of populations in domestic species offers great opportunities to study genome response to selection. The recently published Sheep HapMap dataset is a great example of characterization of the world wide genetic diversity in sheep. In this study, we re-analyzed the Sheep HapMap dataset t...

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Autores principales:	Maria-Ines Fariello, Bertrand Servin, Gwenola Tosser-Klopp, Rachel Rupp, Carole Moreno, International Sheep Genomics Consortium, Magali San Cristobal, Simon Boitard
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f8984c53480a40e4bb130992e2710cf3
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id	oai:doaj.org-article:f8984c53480a40e4bb130992e2710cf3
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spelling	oai:doaj.org-article:f8984c53480a40e4bb130992e2710cf32021-11-25T06:04:29ZSelection signatures in worldwide sheep populations.1932-620310.1371/journal.pone.0103813https://doaj.org/article/f8984c53480a40e4bb130992e2710cf32014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25126940/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203The diversity of populations in domestic species offers great opportunities to study genome response to selection. The recently published Sheep HapMap dataset is a great example of characterization of the world wide genetic diversity in sheep. In this study, we re-analyzed the Sheep HapMap dataset to identify selection signatures in worldwide sheep populations. Compared to previous analyses, we made use of statistical methods that (i) take account of the hierarchical structure of sheep populations, (ii) make use of linkage disequilibrium information and (iii) focus specifically on either recent or older selection signatures. We show that this allows pinpointing several new selection signatures in the sheep genome and distinguishing those related to modern breeding objectives and to earlier post-domestication constraints. The newly identified regions, together with the ones previously identified, reveal the extensive genome response to selection on morphology, color and adaptation to new environments.Maria-Ines FarielloBertrand ServinGwenola Tosser-KloppRachel RuppCarole MorenoInternational Sheep Genomics ConsortiumMagali San CristobalSimon BoitardPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 8, p e103813 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maria-Ines Fariello Bertrand Servin Gwenola Tosser-Klopp Rachel Rupp Carole Moreno International Sheep Genomics Consortium Magali San Cristobal Simon Boitard Selection signatures in worldwide sheep populations.
description	The diversity of populations in domestic species offers great opportunities to study genome response to selection. The recently published Sheep HapMap dataset is a great example of characterization of the world wide genetic diversity in sheep. In this study, we re-analyzed the Sheep HapMap dataset to identify selection signatures in worldwide sheep populations. Compared to previous analyses, we made use of statistical methods that (i) take account of the hierarchical structure of sheep populations, (ii) make use of linkage disequilibrium information and (iii) focus specifically on either recent or older selection signatures. We show that this allows pinpointing several new selection signatures in the sheep genome and distinguishing those related to modern breeding objectives and to earlier post-domestication constraints. The newly identified regions, together with the ones previously identified, reveal the extensive genome response to selection on morphology, color and adaptation to new environments.
format	article
author	Maria-Ines Fariello Bertrand Servin Gwenola Tosser-Klopp Rachel Rupp Carole Moreno International Sheep Genomics Consortium Magali San Cristobal Simon Boitard
author_facet	Maria-Ines Fariello Bertrand Servin Gwenola Tosser-Klopp Rachel Rupp Carole Moreno International Sheep Genomics Consortium Magali San Cristobal Simon Boitard
author_sort	Maria-Ines Fariello
title	Selection signatures in worldwide sheep populations.
title_short	Selection signatures in worldwide sheep populations.
title_full	Selection signatures in worldwide sheep populations.
title_fullStr	Selection signatures in worldwide sheep populations.
title_full_unstemmed	Selection signatures in worldwide sheep populations.
title_sort	selection signatures in worldwide sheep populations.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/f8984c53480a40e4bb130992e2710cf3
work_keys_str_mv	AT mariainesfariello selectionsignaturesinworldwidesheeppopulations AT bertrandservin selectionsignaturesinworldwidesheeppopulations AT gwenolatosserklopp selectionsignaturesinworldwidesheeppopulations AT rachelrupp selectionsignaturesinworldwidesheeppopulations AT carolemoreno selectionsignaturesinworldwidesheeppopulations AT internationalsheepgenomicsconsortium selectionsignaturesinworldwidesheeppopulations AT magalisancristobal selectionsignaturesinworldwidesheeppopulations AT simonboitard selectionsignaturesinworldwidesheeppopulations
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Selection signatures in worldwide sheep populations.

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