The effect of genetic variation on promoter usage and enhancer activity

Expression quantitative trait loci (eQTL) are widely studied, yet the mechanisms by which they exert their effects are largely unknown. Here, performing CAGE-seq on 154 lymphoblastoid cell lines, the authors map regulatory variants associated with promoter usage (puQTLs) and enhancer activity (eaQTL...

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Autores principales:	Marco Garieri, Olivier Delaneau, Federico Santoni, Richard J. Fish, David Mull, Piero Carninci, Emmanouil T. Dermitzakis, Stylianos E. Antonarakis, Alexandre Fort
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f898d3fe6d3f4ed39e819f0b0e5b759b
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spelling	oai:doaj.org-article:f898d3fe6d3f4ed39e819f0b0e5b759b2021-12-02T14:42:39ZThe effect of genetic variation on promoter usage and enhancer activity10.1038/s41467-017-01467-72041-1723https://doaj.org/article/f898d3fe6d3f4ed39e819f0b0e5b759b2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01467-7https://doaj.org/toc/2041-1723Expression quantitative trait loci (eQTL) are widely studied, yet the mechanisms by which they exert their effects are largely unknown. Here, performing CAGE-seq on 154 lymphoblastoid cell lines, the authors map regulatory variants associated with promoter usage (puQTLs) and enhancer activity (eaQTLs).Marco GarieriOlivier DelaneauFederico SantoniRichard J. FishDavid MullPiero CarninciEmmanouil T. DermitzakisStylianos E. AntonarakisAlexandre FortNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marco Garieri Olivier Delaneau Federico Santoni Richard J. Fish David Mull Piero Carninci Emmanouil T. Dermitzakis Stylianos E. Antonarakis Alexandre Fort The effect of genetic variation on promoter usage and enhancer activity
description	Expression quantitative trait loci (eQTL) are widely studied, yet the mechanisms by which they exert their effects are largely unknown. Here, performing CAGE-seq on 154 lymphoblastoid cell lines, the authors map regulatory variants associated with promoter usage (puQTLs) and enhancer activity (eaQTLs).
format	article
author	Marco Garieri Olivier Delaneau Federico Santoni Richard J. Fish David Mull Piero Carninci Emmanouil T. Dermitzakis Stylianos E. Antonarakis Alexandre Fort
author_facet	Marco Garieri Olivier Delaneau Federico Santoni Richard J. Fish David Mull Piero Carninci Emmanouil T. Dermitzakis Stylianos E. Antonarakis Alexandre Fort
author_sort	Marco Garieri
title	The effect of genetic variation on promoter usage and enhancer activity
title_short	The effect of genetic variation on promoter usage and enhancer activity
title_full	The effect of genetic variation on promoter usage and enhancer activity
title_fullStr	The effect of genetic variation on promoter usage and enhancer activity
title_full_unstemmed	The effect of genetic variation on promoter usage and enhancer activity
title_sort	effect of genetic variation on promoter usage and enhancer activity
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f898d3fe6d3f4ed39e819f0b0e5b759b
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The effect of genetic variation on promoter usage and enhancer activity

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