Underlying neurological mechanisms associated with symptomatic convergence insufficiency

Abstract Convergence insufficiency (CI) is the most common binocular vision problem, associated with blurred/double vision, headaches, and sore eyes that are exacerbated when doing prolonged near work, such as reading. The Convergence Insufficiency Neuro-mechanism Adult Population Study (NCT03593031...

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Autores principales:	Tara L. Alvarez, Mitchell Scheiman, Cristian Morales, Suril Gohel, Ayushi Sangoi, Elio M. Santos, Chang Yaramothu, John Vito d’Antonio-Bertagnolli, Xiaobo Li, Bharat B. Biswal
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f8997f8fe5b64bf598bee55eea639191
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spelling	oai:doaj.org-article:f8997f8fe5b64bf598bee55eea6391912021-12-02T13:24:25ZUnderlying neurological mechanisms associated with symptomatic convergence insufficiency10.1038/s41598-021-86171-92045-2322https://doaj.org/article/f8997f8fe5b64bf598bee55eea6391912021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86171-9https://doaj.org/toc/2045-2322Abstract Convergence insufficiency (CI) is the most common binocular vision problem, associated with blurred/double vision, headaches, and sore eyes that are exacerbated when doing prolonged near work, such as reading. The Convergence Insufficiency Neuro-mechanism Adult Population Study (NCT03593031) investigates the mechanistic neural differences between 50 binocularly normal controls (BNC) and 50 symptomatic CI participants by examining the fast and slow fusional disparity vergence systems. The fast fusional system is preprogrammed and is assessed with convergence peak velocity. The slow fusional system optimizes vergence effort and is assessed by measuring the phoria adaptation magnitude and rate. For the fast fusional system, significant differences are observed between the BNC and CI groups for convergence peak velocity, final position amplitude, and functional imaging activity within the secondary visual cortex, right cuneus, and oculomotor vermis. For the slow fusional system, the phoria adaptation magnitude and rate, and the medial cuneus functional activity, are significantly different between the groups. Significant correlations are observed between vergence peak velocity and right cuneus functional activity (p = 0.002) and the rate of phoria adaptation and medial cuneus functional activity (p = 0.02). These results map the brain-behavior of vergence. Future therapeutic interventions may consider implementing procedures that increase cuneus activity for this debilitating disorder.Tara L. AlvarezMitchell ScheimanCristian MoralesSuril GohelAyushi SangoiElio M. SantosChang YaramothuJohn Vito d’Antonio-BertagnolliXiaobo LiBharat B. BiswalNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tara L. Alvarez Mitchell Scheiman Cristian Morales Suril Gohel Ayushi Sangoi Elio M. Santos Chang Yaramothu John Vito d’Antonio-Bertagnolli Xiaobo Li Bharat B. Biswal Underlying neurological mechanisms associated with symptomatic convergence insufficiency
description	Abstract Convergence insufficiency (CI) is the most common binocular vision problem, associated with blurred/double vision, headaches, and sore eyes that are exacerbated when doing prolonged near work, such as reading. The Convergence Insufficiency Neuro-mechanism Adult Population Study (NCT03593031) investigates the mechanistic neural differences between 50 binocularly normal controls (BNC) and 50 symptomatic CI participants by examining the fast and slow fusional disparity vergence systems. The fast fusional system is preprogrammed and is assessed with convergence peak velocity. The slow fusional system optimizes vergence effort and is assessed by measuring the phoria adaptation magnitude and rate. For the fast fusional system, significant differences are observed between the BNC and CI groups for convergence peak velocity, final position amplitude, and functional imaging activity within the secondary visual cortex, right cuneus, and oculomotor vermis. For the slow fusional system, the phoria adaptation magnitude and rate, and the medial cuneus functional activity, are significantly different between the groups. Significant correlations are observed between vergence peak velocity and right cuneus functional activity (p = 0.002) and the rate of phoria adaptation and medial cuneus functional activity (p = 0.02). These results map the brain-behavior of vergence. Future therapeutic interventions may consider implementing procedures that increase cuneus activity for this debilitating disorder.
format	article
author	Tara L. Alvarez Mitchell Scheiman Cristian Morales Suril Gohel Ayushi Sangoi Elio M. Santos Chang Yaramothu John Vito d’Antonio-Bertagnolli Xiaobo Li Bharat B. Biswal
author_facet	Tara L. Alvarez Mitchell Scheiman Cristian Morales Suril Gohel Ayushi Sangoi Elio M. Santos Chang Yaramothu John Vito d’Antonio-Bertagnolli Xiaobo Li Bharat B. Biswal
author_sort	Tara L. Alvarez
title	Underlying neurological mechanisms associated with symptomatic convergence insufficiency
title_short	Underlying neurological mechanisms associated with symptomatic convergence insufficiency
title_full	Underlying neurological mechanisms associated with symptomatic convergence insufficiency
title_fullStr	Underlying neurological mechanisms associated with symptomatic convergence insufficiency
title_full_unstemmed	Underlying neurological mechanisms associated with symptomatic convergence insufficiency
title_sort	underlying neurological mechanisms associated with symptomatic convergence insufficiency
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f8997f8fe5b64bf598bee55eea639191
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Underlying neurological mechanisms associated with symptomatic convergence insufficiency

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