Diabetes-Associated Susceptibility to Tuberculosis: Contribution of Hyperglycemia vs. Dyslipidemia

Diabetes is a major risk factor for tuberculosis (TB). Diabetes increases the risk of the progression from latent tuberculosis infection (LTBI) to active pulmonary TB and TB patients with diabetes are at greater risk of more severe disease and adverse TB treatment outcomes compared to TB patients wi...

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Autores principales:	Minh Dao Ngo, Stacey Bartlett, Katharina Ronacher
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	tuberculosis <i>Mycobacterium tuberculosis</i> diabetes hyperglycemia dyslipidemia cholesterol Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/f89c1303134846f0b4bf9295dcbee7ae
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spelling	oai:doaj.org-article:f89c1303134846f0b4bf9295dcbee7ae2021-11-25T18:24:49ZDiabetes-Associated Susceptibility to Tuberculosis: Contribution of Hyperglycemia vs. Dyslipidemia10.3390/microorganisms91122822076-2607https://doaj.org/article/f89c1303134846f0b4bf9295dcbee7ae2021-11-01T00:00:00Zhttps://www.mdpi.com/2076-2607/9/11/2282https://doaj.org/toc/2076-2607Diabetes is a major risk factor for tuberculosis (TB). Diabetes increases the risk of the progression from latent tuberculosis infection (LTBI) to active pulmonary TB and TB patients with diabetes are at greater risk of more severe disease and adverse TB treatment outcomes compared to TB patients without co-morbidities. Diabetes is a complex disease, characterised not only by hyperglycemia but also by various forms of dyslipidemia. However, the relative contribution of these underlying metabolic factors to increased susceptibility to TB are poorly understood. This review summarises our current knowledge on the epidemiology and clinical manifestation of TB and diabetes comorbidity. We subsequently dissect the relative contributions of body mass index, hyperglycemia, elevated cholesterol and triglycerides on TB disease severity and treatment outcomes. Lastly, we discuss the impact of selected glucose and cholesterol-lowering treatments frequently used in the management of diabetes on TB treatment outcomes.Minh Dao NgoStacey BartlettKatharina RonacherMDPI AGarticletuberculosis<i>Mycobacterium tuberculosis</i>diabeteshyperglycemiadyslipidemiacholesterolBiology (General)QH301-705.5ENMicroorganisms, Vol 9, Iss 2282, p 2282 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	tuberculosis <i>Mycobacterium tuberculosis</i> diabetes hyperglycemia dyslipidemia cholesterol Biology (General) QH301-705.5
spellingShingle	tuberculosis <i>Mycobacterium tuberculosis</i> diabetes hyperglycemia dyslipidemia cholesterol Biology (General) QH301-705.5 Minh Dao Ngo Stacey Bartlett Katharina Ronacher Diabetes-Associated Susceptibility to Tuberculosis: Contribution of Hyperglycemia vs. Dyslipidemia
description	Diabetes is a major risk factor for tuberculosis (TB). Diabetes increases the risk of the progression from latent tuberculosis infection (LTBI) to active pulmonary TB and TB patients with diabetes are at greater risk of more severe disease and adverse TB treatment outcomes compared to TB patients without co-morbidities. Diabetes is a complex disease, characterised not only by hyperglycemia but also by various forms of dyslipidemia. However, the relative contribution of these underlying metabolic factors to increased susceptibility to TB are poorly understood. This review summarises our current knowledge on the epidemiology and clinical manifestation of TB and diabetes comorbidity. We subsequently dissect the relative contributions of body mass index, hyperglycemia, elevated cholesterol and triglycerides on TB disease severity and treatment outcomes. Lastly, we discuss the impact of selected glucose and cholesterol-lowering treatments frequently used in the management of diabetes on TB treatment outcomes.
format	article
author	Minh Dao Ngo Stacey Bartlett Katharina Ronacher
author_facet	Minh Dao Ngo Stacey Bartlett Katharina Ronacher
author_sort	Minh Dao Ngo
title	Diabetes-Associated Susceptibility to Tuberculosis: Contribution of Hyperglycemia vs. Dyslipidemia
title_short	Diabetes-Associated Susceptibility to Tuberculosis: Contribution of Hyperglycemia vs. Dyslipidemia
title_full	Diabetes-Associated Susceptibility to Tuberculosis: Contribution of Hyperglycemia vs. Dyslipidemia
title_fullStr	Diabetes-Associated Susceptibility to Tuberculosis: Contribution of Hyperglycemia vs. Dyslipidemia
title_full_unstemmed	Diabetes-Associated Susceptibility to Tuberculosis: Contribution of Hyperglycemia vs. Dyslipidemia
title_sort	diabetes-associated susceptibility to tuberculosis: contribution of hyperglycemia vs. dyslipidemia
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/f89c1303134846f0b4bf9295dcbee7ae
work_keys_str_mv	AT minhdaongo diabetesassociatedsusceptibilitytotuberculosiscontributionofhyperglycemiavsdyslipidemia AT staceybartlett diabetesassociatedsusceptibilitytotuberculosiscontributionofhyperglycemiavsdyslipidemia AT katharinaronacher diabetesassociatedsusceptibilitytotuberculosiscontributionofhyperglycemiavsdyslipidemia
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Diabetes-Associated Susceptibility to Tuberculosis: Contribution of Hyperglycemia vs. Dyslipidemia

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