Association between ADAMTS13 deficiency and cardiovascular events in chronic hemodialysis patients

Abstract A mild decrease of ADAMTS13 (a disintegrin and metalloprotease with thrombospodin type 1 motif 13) could attribute to stroke and coronary heart disease in general population. However, the role of ADAMTS13 in hemodialysis (HD) patients remains to be explored. This cross-sectional and observa...

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Autores principales:	Shih-Yuan Hung, Tsun-Mei Lin, Hung-Hsiang Liou, Ching-Yang Chen, Wei-Ting Liao, Hsi-Hao Wang, Li-Chun Ho, Ching-Fang Wu, Yi-Che Lee, Min-Yu Chang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f89cd479733d499ebf803a2ae7312b42
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spelling	oai:doaj.org-article:f89cd479733d499ebf803a2ae7312b422021-11-28T12:18:34ZAssociation between ADAMTS13 deficiency and cardiovascular events in chronic hemodialysis patients10.1038/s41598-021-02264-52045-2322https://doaj.org/article/f89cd479733d499ebf803a2ae7312b422021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02264-5https://doaj.org/toc/2045-2322Abstract A mild decrease of ADAMTS13 (a disintegrin and metalloprotease with thrombospodin type 1 motif 13) could attribute to stroke and coronary heart disease in general population. However, the role of ADAMTS13 in hemodialysis (HD) patients remains to be explored. This cross-sectional and observational cohort study enrolled 98 chronic HD patients and 100 normal subjects with the aims to compare the ADAMTS13 activity between chronic HD patients and normal subjects, and to discover the role of ADAMTS13 on the newly developed cardiovascular events for HD patients in a 2-year follow-up. Our HD patients had a significantly lower ADAMTS13 activity than normal subjects, 41.0 ± 22.8% versus 102.3 ± 17.7%, p < 0.001. ADAMTS13 activity was positively correlated with diabetes, triglyceride and hemoglobin A1c, and negatively with high-density lipoprotein cholesterol levels in HD patients. With a follow-up of 20.3 ± 7.3 months, the Cox proportional hazards model revealed that low ADAMTS13, comorbid diabetes, and coronary heart diseases have independent correlations with the development of cardiovascular events. Our study demonstrated that chronic HD patients have a markedly decreased ADAMTS13 activity than normal subjects. Although ADAMTS13 seems to correlate well with diabetes, high triglyceride and low high-density lipoprotein cholesterol levels, ADAMTS13 deficiency still carries an independent risk for cardiovascular events in chronic HD patients.Shih-Yuan HungTsun-Mei LinHung-Hsiang LiouChing-Yang ChenWei-Ting LiaoHsi-Hao WangLi-Chun HoChing-Fang WuYi-Che LeeMin-Yu ChangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shih-Yuan Hung Tsun-Mei Lin Hung-Hsiang Liou Ching-Yang Chen Wei-Ting Liao Hsi-Hao Wang Li-Chun Ho Ching-Fang Wu Yi-Che Lee Min-Yu Chang Association between ADAMTS13 deficiency and cardiovascular events in chronic hemodialysis patients
description	Abstract A mild decrease of ADAMTS13 (a disintegrin and metalloprotease with thrombospodin type 1 motif 13) could attribute to stroke and coronary heart disease in general population. However, the role of ADAMTS13 in hemodialysis (HD) patients remains to be explored. This cross-sectional and observational cohort study enrolled 98 chronic HD patients and 100 normal subjects with the aims to compare the ADAMTS13 activity between chronic HD patients and normal subjects, and to discover the role of ADAMTS13 on the newly developed cardiovascular events for HD patients in a 2-year follow-up. Our HD patients had a significantly lower ADAMTS13 activity than normal subjects, 41.0 ± 22.8% versus 102.3 ± 17.7%, p < 0.001. ADAMTS13 activity was positively correlated with diabetes, triglyceride and hemoglobin A1c, and negatively with high-density lipoprotein cholesterol levels in HD patients. With a follow-up of 20.3 ± 7.3 months, the Cox proportional hazards model revealed that low ADAMTS13, comorbid diabetes, and coronary heart diseases have independent correlations with the development of cardiovascular events. Our study demonstrated that chronic HD patients have a markedly decreased ADAMTS13 activity than normal subjects. Although ADAMTS13 seems to correlate well with diabetes, high triglyceride and low high-density lipoprotein cholesterol levels, ADAMTS13 deficiency still carries an independent risk for cardiovascular events in chronic HD patients.
format	article
author	Shih-Yuan Hung Tsun-Mei Lin Hung-Hsiang Liou Ching-Yang Chen Wei-Ting Liao Hsi-Hao Wang Li-Chun Ho Ching-Fang Wu Yi-Che Lee Min-Yu Chang
author_facet	Shih-Yuan Hung Tsun-Mei Lin Hung-Hsiang Liou Ching-Yang Chen Wei-Ting Liao Hsi-Hao Wang Li-Chun Ho Ching-Fang Wu Yi-Che Lee Min-Yu Chang
author_sort	Shih-Yuan Hung
title	Association between ADAMTS13 deficiency and cardiovascular events in chronic hemodialysis patients
title_short	Association between ADAMTS13 deficiency and cardiovascular events in chronic hemodialysis patients
title_full	Association between ADAMTS13 deficiency and cardiovascular events in chronic hemodialysis patients
title_fullStr	Association between ADAMTS13 deficiency and cardiovascular events in chronic hemodialysis patients
title_full_unstemmed	Association between ADAMTS13 deficiency and cardiovascular events in chronic hemodialysis patients
title_sort	association between adamts13 deficiency and cardiovascular events in chronic hemodialysis patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f89cd479733d499ebf803a2ae7312b42
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Association between ADAMTS13 deficiency and cardiovascular events in chronic hemodialysis patients

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