Humanized Mice as a Valuable Pre-Clinical Model for Cancer Immunotherapy Research

Immunotherapy with checkpoint inhibitors opened new horizons in cancer treatment. Clinical trials for novel immunotherapies or unexplored combination regimens either need years of development or are simply impossible to perform like is the case in cancer patients with limited life expectancy. Thus,...

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Autores principales:	Morgane M. Cogels, Redouane Rouas, Ghanem E. Ghanem, Philippe Martinive, Ahmad Awada, Dirk Van Gestel, Mohammad Krayem
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	humanized mice preclinical model cancer immunotherapy oncoimmunology Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/f8a3350124704c5bae4f1813a914b018
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spelling	oai:doaj.org-article:f8a3350124704c5bae4f1813a914b0182021-11-18T04:42:22ZHumanized Mice as a Valuable Pre-Clinical Model for Cancer Immunotherapy Research2234-943X10.3389/fonc.2021.784947https://doaj.org/article/f8a3350124704c5bae4f1813a914b0182021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.784947/fullhttps://doaj.org/toc/2234-943XImmunotherapy with checkpoint inhibitors opened new horizons in cancer treatment. Clinical trials for novel immunotherapies or unexplored combination regimens either need years of development or are simply impossible to perform like is the case in cancer patients with limited life expectancy. Thus, the need for preclinical models that rapidly and safely allow for a better understanding of underlying mechanisms, drug kinetics and toxicity leading to the selection of the best regimen to be translated into the clinic, is of high importance. Humanized mice that can bear both human immune system and human tumors, are increasingly used in recent preclinical immunotherapy studies and represent a remarkably unprecedented tool in this field. In this review, we describe, summarize, and discuss the recent advances of humanized mouse models used for cancer immunotherapy research and the challenges faced during their establishment. We also highlight the lack of preclinical studies using this model for radiotherapy-based research and argue that it can be a great asset to understand and answer many open questions around radiation therapy such as its presumed associated “abscopal effect”.Morgane M. CogelsMorgane M. CogelsRedouane RouasGhanem E. GhanemPhilippe MartiniveAhmad AwadaAhmad AwadaDirk Van GestelMohammad KrayemMohammad KrayemFrontiers Media S.A.articlehumanized micepreclinical modelcancerimmunotherapyoncoimmunologyNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	humanized mice preclinical model cancer immunotherapy oncoimmunology Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	humanized mice preclinical model cancer immunotherapy oncoimmunology Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Morgane M. Cogels Morgane M. Cogels Redouane Rouas Ghanem E. Ghanem Philippe Martinive Ahmad Awada Ahmad Awada Dirk Van Gestel Mohammad Krayem Mohammad Krayem Humanized Mice as a Valuable Pre-Clinical Model for Cancer Immunotherapy Research
description	Immunotherapy with checkpoint inhibitors opened new horizons in cancer treatment. Clinical trials for novel immunotherapies or unexplored combination regimens either need years of development or are simply impossible to perform like is the case in cancer patients with limited life expectancy. Thus, the need for preclinical models that rapidly and safely allow for a better understanding of underlying mechanisms, drug kinetics and toxicity leading to the selection of the best regimen to be translated into the clinic, is of high importance. Humanized mice that can bear both human immune system and human tumors, are increasingly used in recent preclinical immunotherapy studies and represent a remarkably unprecedented tool in this field. In this review, we describe, summarize, and discuss the recent advances of humanized mouse models used for cancer immunotherapy research and the challenges faced during their establishment. We also highlight the lack of preclinical studies using this model for radiotherapy-based research and argue that it can be a great asset to understand and answer many open questions around radiation therapy such as its presumed associated “abscopal effect”.
format	article
author	Morgane M. Cogels Morgane M. Cogels Redouane Rouas Ghanem E. Ghanem Philippe Martinive Ahmad Awada Ahmad Awada Dirk Van Gestel Mohammad Krayem Mohammad Krayem
author_facet	Morgane M. Cogels Morgane M. Cogels Redouane Rouas Ghanem E. Ghanem Philippe Martinive Ahmad Awada Ahmad Awada Dirk Van Gestel Mohammad Krayem Mohammad Krayem
author_sort	Morgane M. Cogels
title	Humanized Mice as a Valuable Pre-Clinical Model for Cancer Immunotherapy Research
title_short	Humanized Mice as a Valuable Pre-Clinical Model for Cancer Immunotherapy Research
title_full	Humanized Mice as a Valuable Pre-Clinical Model for Cancer Immunotherapy Research
title_fullStr	Humanized Mice as a Valuable Pre-Clinical Model for Cancer Immunotherapy Research
title_full_unstemmed	Humanized Mice as a Valuable Pre-Clinical Model for Cancer Immunotherapy Research
title_sort	humanized mice as a valuable pre-clinical model for cancer immunotherapy research
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/f8a3350124704c5bae4f1813a914b018
work_keys_str_mv	AT morganemcogels humanizedmiceasavaluablepreclinicalmodelforcancerimmunotherapyresearch AT morganemcogels humanizedmiceasavaluablepreclinicalmodelforcancerimmunotherapyresearch AT redouanerouas humanizedmiceasavaluablepreclinicalmodelforcancerimmunotherapyresearch AT ghanemeghanem humanizedmiceasavaluablepreclinicalmodelforcancerimmunotherapyresearch AT philippemartinive humanizedmiceasavaluablepreclinicalmodelforcancerimmunotherapyresearch AT ahmadawada humanizedmiceasavaluablepreclinicalmodelforcancerimmunotherapyresearch AT ahmadawada humanizedmiceasavaluablepreclinicalmodelforcancerimmunotherapyresearch AT dirkvangestel humanizedmiceasavaluablepreclinicalmodelforcancerimmunotherapyresearch AT mohammadkrayem humanizedmiceasavaluablepreclinicalmodelforcancerimmunotherapyresearch AT mohammadkrayem humanizedmiceasavaluablepreclinicalmodelforcancerimmunotherapyresearch
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Humanized Mice as a Valuable Pre-Clinical Model for Cancer Immunotherapy Research

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