The system of osteoprotegrin (OPG)/ligand of NF-kB receptor activator (RANKL) in patients with diabetes mellitus, mediacalcinosis and obliteratingatherosclerosis of lower leg arteries

Aim. To study the OPG/RANKL system in patients with diabetes mellitus, mediacalcinosis and obliterating atherosclerosis of lower leg arteries. Materials and methods. The study enrolled 70 patients including 20 with manifest diabetic neuropathy (DN) and mediacalcinosis of lower leg arteries(group 1...

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Autores principales:	Марианна Viktorovna Yaroslavtseva, Irina Nikolaevna Ul'yanova, Gagik Radikovich Galstyan, A V Ilin, L V Nikankina, Oleg Valer'evich Remizov, Ivan Ivanovich Dedov
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2009
Materias:	osteoprotegrin rankl mediacalcinosis obliterating atherosclerosis Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/f8a352a263504463b70f557243c15cad
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spelling	oai:doaj.org-article:f8a352a263504463b70f557243c15cad2021-11-14T09:00:13ZThe system of osteoprotegrin (OPG)/ligand of NF-kB receptor activator (RANKL) in patients with diabetes mellitus, mediacalcinosis and obliteratingatherosclerosis of lower leg arteries2072-03512072-037810.14341/2072-0351-5416https://doaj.org/article/f8a352a263504463b70f557243c15cad2009-03-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/5416https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Aim. To study the OPG/RANKL system in patients with diabetes mellitus, mediacalcinosis and obliterating atherosclerosis of lower leg arteries. Materials and methods. The study enrolled 70 patients including 20 with manifest diabetic neuropathy (DN) and mediacalcinosis of lower leg arteries(group 1). 29 patients with diabetes mellitus (DM) and clinical manifestations of obliterating atherosclerosis of lower leg arteries comprised group 2. Thecontrol group 3 consisted of 30 subjects without disturbances of carbohydrate metabolism. Immunoassays with Alkphase-B (Metra biosystems, USA),Osteoprotegrin (Biomedica, Austria), and sRANKL(Biomedica, Austria) kits were used to detect serum markers of bone formation (alkaline phosphatase(AP), OPG, and RANKL respectively). The patients underwent examination by digital X-ray of affected joints in frontal and lateral projections using anAxiom Iconos R 200 apparatus (Siemens, Germany). Bone mineral density (BMD) was measured by dual energy X-ray absorptiometry (Expert 1188,Lunar, USA). Ultrasound duplex scanning of lower leg arteries was performed with Sonoc-5500 (Agilent, USA). Results. OPG levels in diabetic patients were significantly higher than in controls (pМарианна Viktorovna YaroslavtsevaIrina Nikolaevna Ul'yanovaGagik Radikovich GalstyanA V IlinL V NikankinaOleg Valer'evich RemizovIvan Ivanovich DedovEndocrinology Research Centrearticleosteoprotegrinranklmediacalcinosisobliterating atherosclerosisNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 12, Iss 1, Pp 25-28 (2009)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	osteoprotegrin rankl mediacalcinosis obliterating atherosclerosis Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	osteoprotegrin rankl mediacalcinosis obliterating atherosclerosis Nutritional diseases. Deficiency diseases RC620-627 Марианна Viktorovna Yaroslavtseva Irina Nikolaevna Ul'yanova Gagik Radikovich Galstyan A V Ilin L V Nikankina Oleg Valer'evich Remizov Ivan Ivanovich Dedov The system of osteoprotegrin (OPG)/ligand of NF-kB receptor activator (RANKL) in patients with diabetes mellitus, mediacalcinosis and obliteratingatherosclerosis of lower leg arteries
description	Aim. To study the OPG/RANKL system in patients with diabetes mellitus, mediacalcinosis and obliterating atherosclerosis of lower leg arteries. Materials and methods. The study enrolled 70 patients including 20 with manifest diabetic neuropathy (DN) and mediacalcinosis of lower leg arteries(group 1). 29 patients with diabetes mellitus (DM) and clinical manifestations of obliterating atherosclerosis of lower leg arteries comprised group 2. Thecontrol group 3 consisted of 30 subjects without disturbances of carbohydrate metabolism. Immunoassays with Alkphase-B (Metra biosystems, USA),Osteoprotegrin (Biomedica, Austria), and sRANKL(Biomedica, Austria) kits were used to detect serum markers of bone formation (alkaline phosphatase(AP), OPG, and RANKL respectively). The patients underwent examination by digital X-ray of affected joints in frontal and lateral projections using anAxiom Iconos R 200 apparatus (Siemens, Germany). Bone mineral density (BMD) was measured by dual energy X-ray absorptiometry (Expert 1188,Lunar, USA). Ultrasound duplex scanning of lower leg arteries was performed with Sonoc-5500 (Agilent, USA). Results. OPG levels in diabetic patients were significantly higher than in controls (p
format	article
author	Марианна Viktorovna Yaroslavtseva Irina Nikolaevna Ul'yanova Gagik Radikovich Galstyan A V Ilin L V Nikankina Oleg Valer'evich Remizov Ivan Ivanovich Dedov
author_facet	Марианна Viktorovna Yaroslavtseva Irina Nikolaevna Ul'yanova Gagik Radikovich Galstyan A V Ilin L V Nikankina Oleg Valer'evich Remizov Ivan Ivanovich Dedov
author_sort	Марианна Viktorovna Yaroslavtseva
title	The system of osteoprotegrin (OPG)/ligand of NF-kB receptor activator (RANKL) in patients with diabetes mellitus, mediacalcinosis and obliteratingatherosclerosis of lower leg arteries
title_short	The system of osteoprotegrin (OPG)/ligand of NF-kB receptor activator (RANKL) in patients with diabetes mellitus, mediacalcinosis and obliteratingatherosclerosis of lower leg arteries
title_full	The system of osteoprotegrin (OPG)/ligand of NF-kB receptor activator (RANKL) in patients with diabetes mellitus, mediacalcinosis and obliteratingatherosclerosis of lower leg arteries
title_fullStr	The system of osteoprotegrin (OPG)/ligand of NF-kB receptor activator (RANKL) in patients with diabetes mellitus, mediacalcinosis and obliteratingatherosclerosis of lower leg arteries
title_full_unstemmed	The system of osteoprotegrin (OPG)/ligand of NF-kB receptor activator (RANKL) in patients with diabetes mellitus, mediacalcinosis and obliteratingatherosclerosis of lower leg arteries
title_sort	system of osteoprotegrin (opg)/ligand of nf-kb receptor activator (rankl) in patients with diabetes mellitus, mediacalcinosis and obliteratingatherosclerosis of lower leg arteries
publisher	Endocrinology Research Centre
publishDate	2009
url	https://doaj.org/article/f8a352a263504463b70f557243c15cad
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The system of osteoprotegrin (OPG)/ligand of NF-kB receptor activator (RANKL) in patients with diabetes mellitus, mediacalcinosis and obliteratingatherosclerosis of lower leg arteries

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