Cep55 regulation of PI3K/Akt signaling is required for neocortical development and ciliogenesis.

Cep55 regulation of PI3K/Akt signaling is required for neocortical development and ciliogenesis.

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Homozygous nonsense mutations in CEP55 are associated with several congenital malformations that lead to perinatal lethality suggesting that it plays a critical role in regulation of embryonic development. CEP55 has previously been studied as a crucial regulator of cytokinesis, predominantly in tran...

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Autores principales: Behnam Rashidieh, Belal Shohayeb, Amanda Louise Bain, Patrick R J Fortuna, Debottam Sinha, Andrew Burgess, Richard Mills, Rachael C Adams, J Alejandro Lopez, Peter Blumbergs, John Finnie, Murugan Kalimutho, Michael Piper, James Edward Hudson, Dominic C H Ng, Kum Kum Khanna
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2021
Materias:
Genetics
QH426-470
Acceso en línea:https://doaj.org/article/f8a4d81f071f4f57a27dc411b7082140
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