A splicing isoform of TEAD4 attenuates the Hippo–YAP signalling to inhibit tumour proliferation

The Hippo/Yap signalling pathway is found deregulated in several cancers. Here, the authors uncover an additional mechanism of YAP regulation that occurs via alternately spliced isoform of TEAD4, which acts as a dominant negative regulator of YAP-TEAD signalling.

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Autores principales:	Yangfan Qi, Jing Yu, Wei Han, Xiaojuan Fan, Haili Qian, Huanhuan Wei, Yi-hsuan S. Tsai, Jinyao Zhao, Wenjing Zhang, Quentin Liu, Songshu Meng, Yang Wang, Zefeng Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f8a4ec7f1fc64a198fd124141bb70228
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spelling	oai:doaj.org-article:f8a4ec7f1fc64a198fd124141bb702282021-12-02T14:39:12ZA splicing isoform of TEAD4 attenuates the Hippo–YAP signalling to inhibit tumour proliferation10.1038/ncomms118402041-1723https://doaj.org/article/f8a4ec7f1fc64a198fd124141bb702282016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11840https://doaj.org/toc/2041-1723The Hippo/Yap signalling pathway is found deregulated in several cancers. Here, the authors uncover an additional mechanism of YAP regulation that occurs via alternately spliced isoform of TEAD4, which acts as a dominant negative regulator of YAP-TEAD signalling.Yangfan QiJing YuWei HanXiaojuan FanHaili QianHuanhuan WeiYi-hsuan S. TsaiJinyao ZhaoWenjing ZhangQuentin LiuSongshu MengYang WangZefeng WangNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yangfan Qi Jing Yu Wei Han Xiaojuan Fan Haili Qian Huanhuan Wei Yi-hsuan S. Tsai Jinyao Zhao Wenjing Zhang Quentin Liu Songshu Meng Yang Wang Zefeng Wang A splicing isoform of TEAD4 attenuates the Hippo–YAP signalling to inhibit tumour proliferation
description	The Hippo/Yap signalling pathway is found deregulated in several cancers. Here, the authors uncover an additional mechanism of YAP regulation that occurs via alternately spliced isoform of TEAD4, which acts as a dominant negative regulator of YAP-TEAD signalling.
format	article
author	Yangfan Qi Jing Yu Wei Han Xiaojuan Fan Haili Qian Huanhuan Wei Yi-hsuan S. Tsai Jinyao Zhao Wenjing Zhang Quentin Liu Songshu Meng Yang Wang Zefeng Wang
author_facet	Yangfan Qi Jing Yu Wei Han Xiaojuan Fan Haili Qian Huanhuan Wei Yi-hsuan S. Tsai Jinyao Zhao Wenjing Zhang Quentin Liu Songshu Meng Yang Wang Zefeng Wang
author_sort	Yangfan Qi
title	A splicing isoform of TEAD4 attenuates the Hippo–YAP signalling to inhibit tumour proliferation
title_short	A splicing isoform of TEAD4 attenuates the Hippo–YAP signalling to inhibit tumour proliferation
title_full	A splicing isoform of TEAD4 attenuates the Hippo–YAP signalling to inhibit tumour proliferation
title_fullStr	A splicing isoform of TEAD4 attenuates the Hippo–YAP signalling to inhibit tumour proliferation
title_full_unstemmed	A splicing isoform of TEAD4 attenuates the Hippo–YAP signalling to inhibit tumour proliferation
title_sort	splicing isoform of tead4 attenuates the hippo–yap signalling to inhibit tumour proliferation
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/f8a4ec7f1fc64a198fd124141bb70228
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A splicing isoform of TEAD4 attenuates the Hippo–YAP signalling to inhibit tumour proliferation

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