A splicing isoform of TEAD4 attenuates the Hippo–YAP signalling to inhibit tumour proliferation

A splicing isoform of TEAD4 attenuates the Hippo–YAP signalling to inhibit tumour proliferation

The Hippo/Yap signalling pathway is found deregulated in several cancers. Here, the authors uncover an additional mechanism of YAP regulation that occurs via alternately spliced isoform of TEAD4, which acts as a dominant negative regulator of YAP-TEAD signalling.

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Detalles Bibliográficos
Autores principales: Yangfan Qi, Jing Yu, Wei Han, Xiaojuan Fan, Haili Qian, Huanhuan Wei, Yi-hsuan S. Tsai, Jinyao Zhao, Wenjing Zhang, Quentin Liu, Songshu Meng, Yang Wang, Zefeng Wang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/f8a4ec7f1fc64a198fd124141bb70228
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