Shorter incubation period is associated with severe disease progression in patients with COVID-19
The diagnosed COVID-19 cases revealed that the incubation periods (IP) varied a lot among patients. However, few studies had emphasized on the different clinical features and prognosis of patients with different IP. A total of 330 patients with laboratory-confirmed COVID-19 were enrolled and classif...
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Taylor & Francis Group
2020
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oai:doaj.org-article:f8a6dad879d943c1b94e8044420806d62021-11-17T14:21:59ZShorter incubation period is associated with severe disease progression in patients with COVID-192150-55942150-560810.1080/21505594.2020.1836894https://doaj.org/article/f8a6dad879d943c1b94e8044420806d62020-12-01T00:00:00Zhttp://dx.doi.org/10.1080/21505594.2020.1836894https://doaj.org/toc/2150-5594https://doaj.org/toc/2150-5608The diagnosed COVID-19 cases revealed that the incubation periods (IP) varied a lot among patients. However, few studies had emphasized on the different clinical features and prognosis of patients with different IP. A total of 330 patients with laboratory-confirmed COVID-19 were enrolled and classified into immediate onset group(IP<3 days, I group, 57 cases) and late onset group(IP>10 days, L group, 75 cases) based on IP. The difference of clinical characteristics and prognosis of the two groups were compared. There were more patients with fever in I group than in L group(P = 0.003), and counts of all the total lymphocytes, total T lymphocytes, CD4 + and CD8 + T lymphocytes were significantly different between the two groups(all P < 0.01). Besides, patients in L group had more GGOs in CT scan than I group and there were more patients in I group receiving antibiotic treatment than in L group(P < 0.001). For disease aggravation, the median CT scores were comparable between the two groups, but individually, there were more patients with increased CT score during hospitalization in I group than in L group. The aggravation incidence of CT presentation was 21.1% in I group, significantly higher than L group(8.0%, P = 0.042). Multivariable COX models suggested that IP was the only independent factors for CT aggravation. Conclusively, patients with different IP were different in clinical symptoms, laboratory tests, and CT presentations. Shorter IP was associated with the aggravation of lung involvement in CT scan.Changxiang LaiRentao YuMingbo WangWenjie XianXin ZhaoQiyuan TangRuikun ChenXuan ZhouXuan LiZhiyu LiZhiwei LiGuohong DengFang WangTaylor & Francis Grouparticleincubation periodcovid-19sars-cov-2disease aggravationct scoresInfectious and parasitic diseasesRC109-216ENVirulence, Vol 11, Iss 1, Pp 1443-1452 (2020) |
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incubation period covid-19 sars-cov-2 disease aggravation ct scores Infectious and parasitic diseases RC109-216 |
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incubation period covid-19 sars-cov-2 disease aggravation ct scores Infectious and parasitic diseases RC109-216 Changxiang Lai Rentao Yu Mingbo Wang Wenjie Xian Xin Zhao Qiyuan Tang Ruikun Chen Xuan Zhou Xuan Li Zhiyu Li Zhiwei Li Guohong Deng Fang Wang Shorter incubation period is associated with severe disease progression in patients with COVID-19 |
| description |
The diagnosed COVID-19 cases revealed that the incubation periods (IP) varied a lot among patients. However, few studies had emphasized on the different clinical features and prognosis of patients with different IP. A total of 330 patients with laboratory-confirmed COVID-19 were enrolled and classified into immediate onset group(IP<3 days, I group, 57 cases) and late onset group(IP>10 days, L group, 75 cases) based on IP. The difference of clinical characteristics and prognosis of the two groups were compared. There were more patients with fever in I group than in L group(P = 0.003), and counts of all the total lymphocytes, total T lymphocytes, CD4 + and CD8 + T lymphocytes were significantly different between the two groups(all P < 0.01). Besides, patients in L group had more GGOs in CT scan than I group and there were more patients in I group receiving antibiotic treatment than in L group(P < 0.001). For disease aggravation, the median CT scores were comparable between the two groups, but individually, there were more patients with increased CT score during hospitalization in I group than in L group. The aggravation incidence of CT presentation was 21.1% in I group, significantly higher than L group(8.0%, P = 0.042). Multivariable COX models suggested that IP was the only independent factors for CT aggravation. Conclusively, patients with different IP were different in clinical symptoms, laboratory tests, and CT presentations. Shorter IP was associated with the aggravation of lung involvement in CT scan. |
| format |
article |
| author |
Changxiang Lai Rentao Yu Mingbo Wang Wenjie Xian Xin Zhao Qiyuan Tang Ruikun Chen Xuan Zhou Xuan Li Zhiyu Li Zhiwei Li Guohong Deng Fang Wang |
| author_facet |
Changxiang Lai Rentao Yu Mingbo Wang Wenjie Xian Xin Zhao Qiyuan Tang Ruikun Chen Xuan Zhou Xuan Li Zhiyu Li Zhiwei Li Guohong Deng Fang Wang |
| author_sort |
Changxiang Lai |
| title |
Shorter incubation period is associated with severe disease progression in patients with COVID-19 |
| title_short |
Shorter incubation period is associated with severe disease progression in patients with COVID-19 |
| title_full |
Shorter incubation period is associated with severe disease progression in patients with COVID-19 |
| title_fullStr |
Shorter incubation period is associated with severe disease progression in patients with COVID-19 |
| title_full_unstemmed |
Shorter incubation period is associated with severe disease progression in patients with COVID-19 |
| title_sort |
shorter incubation period is associated with severe disease progression in patients with covid-19 |
| publisher |
Taylor & Francis Group |
| publishDate |
2020 |
| url |
https://doaj.org/article/f8a6dad879d943c1b94e8044420806d6 |
| work_keys_str_mv |
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