Investigation of candidal species among people who suffer from oral potentially malignant disorders and oral squamous cell carcinoma

Aim and Objective: The aim of the present study was to evaluate the candidal species among masses with oral potentially malignant disorders and oral squamous cell carcinoma. Materials and Methods: This prospective and observational study was conducted by the Department of Oral Pathology and Microbio...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Mohammed Abidullah, Sunitha Bhosle, Bruhathi Komire, Priyadarshini Sharma, K Swathi, L Karthik
Formato:	article
Lenguaje:	EN
Publicado:	Wolters Kluwer Medknow Publications 2021
Materias:	candida albicans carcinogenesis chrom agar oral squamous cell carcinoma potentially malignant disorders sabouraud dextrose agar Pharmacy and materia medica RS1-441 Analytical chemistry QD71-142
Acceso en línea:	https://doaj.org/article/f8a883dbba534026916025e3e7f6145a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f8a883dbba534026916025e3e7f6145a
record_format	dspace
spelling	oai:doaj.org-article:f8a883dbba534026916025e3e7f6145a2021-11-19T12:15:52ZInvestigation of candidal species among people who suffer from oral potentially malignant disorders and oral squamous cell carcinoma0975-740610.4103/jpbs.jpbs_357_21https://doaj.org/article/f8a883dbba534026916025e3e7f6145a2021-01-01T00:00:00Zhttp://www.jpbsonline.org/article.asp?issn=0975-7406;year=2021;volume=13;issue=6;spage=1050;epage=1054;aulast=Abidullahhttps://doaj.org/toc/0975-7406Aim and Objective: The aim of the present study was to evaluate the candidal species among masses with oral potentially malignant disorders and oral squamous cell carcinoma. Materials and Methods: This prospective and observational study was conducted by the Department of Oral Pathology and Microbiology, S. B. Patil Dental College, Bidar, Karnataka, India, from February 2018 to January 2019. The study composed of total of 150 individuals, of which 50 individuals did not had any visible manifestations, 50 were analyzed with potentially malignant disorders (PMDs) in particular oral leukoplakia, oral lichen planus, and oral submucous fibrosis and last group of 50 individuals were suffering from oral squamous cell carcinoma (OSCC). First, the swab samples were elicited from culture technique after that incisional biopsy of the discernible investigated lesion was done for the purpose of justopathological verification. The swab samples were streak on Sabouraud dextrose agar (SDA) and HiCrome Candida Differential HiVeg agar/CHROMagar medium and incubation at 37°C for 24–48 h. Biopsy was done for all the samples. Results: The proportion of candidates as men and women in control was 45 (90%) and 5 (10%), in PMD was 30 (60%) and 20 (40%), and in OSCC was 45 (90%) and 5 (10%), correspondingly. On evaluation on SDA medium in controls, PMD and OSCC groups, Candida was founded in 14 (28%), 20 (40%), and 42 (84%) and not founded in 36 (72%), 30 (60%), and 8 (16%) folks, subsequently. Intragroup contrast illustrated exceedingly necessary distinction with P = 0.000 between both controls versus OSCC and PMD in comparison to OSCC. Nevertheless, controls versus PMD manifested insignificant, P = 0.119. Investigation on CHROM AGAR media among controls, PMD and OSCC groups, Candida species was seen in 11 (22%), 19 (38%), and 40 (80%) and absent in 39 (78%), 31 (62%), and 10 (20%) individuals, respectively. On statistical inspection, the variations noted were enormous, (P = 0.000). On speciation of Candida in CHROM agar among the controls, PMD and OSCC groups, Candida albicans species was present in 9 (18%), 16 (32%), and 6 (12%), Candida krusei in 3 (6%), 6 (12%), and 13 (26%), Candida glabrata in 0, 0, and 8 (16%), and Candida tropicalis in 0, 0, and 3 (6%) cases, respectively. Nonetheless, only OSCC group reveal amalgamation of species such as C. glabrata and C. krusei was present in 2 (4%) case, C. tropicalis and C. krusei in was present 3 (6%) cases, C. tropicalis and C. glabrata was present in 2 (4%) case, C. albicans and C. tropicalis was present in 2 (4%) cases, and C. krusei, C. glabrata with C. albicans was present in 1 (2%) case, respectively. All other types of fungi were regarded as infectious excluding Candida, on analysis on SDA medium, infestation in the form of fungal molds was seen in 18 (36%) in controls, 12 (24%) in PMD and 8 (16%) in OSCC groups. Conclusion: We interpreted that the chief carrier of candidal species in PMDs and OSCC, yet more light is to be thrown on the topic that Candida has particular establishment in PMDs or in malignancy.Mohammed AbidullahSunitha BhosleBruhathi KomirePriyadarshini SharmaK SwathiL KarthikWolters Kluwer Medknow Publicationsarticlecandida albicanscarcinogenesischrom agaroral squamous cell carcinomapotentially malignant disorderssabouraud dextrose agarPharmacy and materia medicaRS1-441Analytical chemistryQD71-142ENJournal of Pharmacy and Bioallied Sciences, Vol 13, Iss 6, Pp 1050-1054 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	candida albicans carcinogenesis chrom agar oral squamous cell carcinoma potentially malignant disorders sabouraud dextrose agar Pharmacy and materia medica RS1-441 Analytical chemistry QD71-142
spellingShingle	candida albicans carcinogenesis chrom agar oral squamous cell carcinoma potentially malignant disorders sabouraud dextrose agar Pharmacy and materia medica RS1-441 Analytical chemistry QD71-142 Mohammed Abidullah Sunitha Bhosle Bruhathi Komire Priyadarshini Sharma K Swathi L Karthik Investigation of candidal species among people who suffer from oral potentially malignant disorders and oral squamous cell carcinoma
description	Aim and Objective: The aim of the present study was to evaluate the candidal species among masses with oral potentially malignant disorders and oral squamous cell carcinoma. Materials and Methods: This prospective and observational study was conducted by the Department of Oral Pathology and Microbiology, S. B. Patil Dental College, Bidar, Karnataka, India, from February 2018 to January 2019. The study composed of total of 150 individuals, of which 50 individuals did not had any visible manifestations, 50 were analyzed with potentially malignant disorders (PMDs) in particular oral leukoplakia, oral lichen planus, and oral submucous fibrosis and last group of 50 individuals were suffering from oral squamous cell carcinoma (OSCC). First, the swab samples were elicited from culture technique after that incisional biopsy of the discernible investigated lesion was done for the purpose of justopathological verification. The swab samples were streak on Sabouraud dextrose agar (SDA) and HiCrome Candida Differential HiVeg agar/CHROMagar medium and incubation at 37°C for 24–48 h. Biopsy was done for all the samples. Results: The proportion of candidates as men and women in control was 45 (90%) and 5 (10%), in PMD was 30 (60%) and 20 (40%), and in OSCC was 45 (90%) and 5 (10%), correspondingly. On evaluation on SDA medium in controls, PMD and OSCC groups, Candida was founded in 14 (28%), 20 (40%), and 42 (84%) and not founded in 36 (72%), 30 (60%), and 8 (16%) folks, subsequently. Intragroup contrast illustrated exceedingly necessary distinction with P = 0.000 between both controls versus OSCC and PMD in comparison to OSCC. Nevertheless, controls versus PMD manifested insignificant, P = 0.119. Investigation on CHROM AGAR media among controls, PMD and OSCC groups, Candida species was seen in 11 (22%), 19 (38%), and 40 (80%) and absent in 39 (78%), 31 (62%), and 10 (20%) individuals, respectively. On statistical inspection, the variations noted were enormous, (P = 0.000). On speciation of Candida in CHROM agar among the controls, PMD and OSCC groups, Candida albicans species was present in 9 (18%), 16 (32%), and 6 (12%), Candida krusei in 3 (6%), 6 (12%), and 13 (26%), Candida glabrata in 0, 0, and 8 (16%), and Candida tropicalis in 0, 0, and 3 (6%) cases, respectively. Nonetheless, only OSCC group reveal amalgamation of species such as C. glabrata and C. krusei was present in 2 (4%) case, C. tropicalis and C. krusei in was present 3 (6%) cases, C. tropicalis and C. glabrata was present in 2 (4%) case, C. albicans and C. tropicalis was present in 2 (4%) cases, and C. krusei, C. glabrata with C. albicans was present in 1 (2%) case, respectively. All other types of fungi were regarded as infectious excluding Candida, on analysis on SDA medium, infestation in the form of fungal molds was seen in 18 (36%) in controls, 12 (24%) in PMD and 8 (16%) in OSCC groups. Conclusion: We interpreted that the chief carrier of candidal species in PMDs and OSCC, yet more light is to be thrown on the topic that Candida has particular establishment in PMDs or in malignancy.
format	article
author	Mohammed Abidullah Sunitha Bhosle Bruhathi Komire Priyadarshini Sharma K Swathi L Karthik
author_facet	Mohammed Abidullah Sunitha Bhosle Bruhathi Komire Priyadarshini Sharma K Swathi L Karthik
author_sort	Mohammed Abidullah
title	Investigation of candidal species among people who suffer from oral potentially malignant disorders and oral squamous cell carcinoma
title_short	Investigation of candidal species among people who suffer from oral potentially malignant disorders and oral squamous cell carcinoma
title_full	Investigation of candidal species among people who suffer from oral potentially malignant disorders and oral squamous cell carcinoma
title_fullStr	Investigation of candidal species among people who suffer from oral potentially malignant disorders and oral squamous cell carcinoma
title_full_unstemmed	Investigation of candidal species among people who suffer from oral potentially malignant disorders and oral squamous cell carcinoma
title_sort	investigation of candidal species among people who suffer from oral potentially malignant disorders and oral squamous cell carcinoma
publisher	Wolters Kluwer Medknow Publications
publishDate	2021
url	https://doaj.org/article/f8a883dbba534026916025e3e7f6145a
work_keys_str_mv	AT mohammedabidullah investigationofcandidalspeciesamongpeoplewhosufferfromoralpotentiallymalignantdisordersandoralsquamouscellcarcinoma AT sunithabhosle investigationofcandidalspeciesamongpeoplewhosufferfromoralpotentiallymalignantdisordersandoralsquamouscellcarcinoma AT bruhathikomire investigationofcandidalspeciesamongpeoplewhosufferfromoralpotentiallymalignantdisordersandoralsquamouscellcarcinoma AT priyadarshinisharma investigationofcandidalspeciesamongpeoplewhosufferfromoralpotentiallymalignantdisordersandoralsquamouscellcarcinoma AT kswathi investigationofcandidalspeciesamongpeoplewhosufferfromoralpotentiallymalignantdisordersandoralsquamouscellcarcinoma AT lkarthik investigationofcandidalspeciesamongpeoplewhosufferfromoralpotentiallymalignantdisordersandoralsquamouscellcarcinoma
_version_	1718420170527997952

Investigation of candidal species among people who suffer from oral potentially malignant disorders and oral squamous cell carcinoma

Ejemplares similares