Heartbeat evoked potentials in patients with post-traumatic stress disorder: an unaltered neurobiological regulation system?

Background Early life maltreatment is a risk factor for psychiatric disorders, including post-traumatic stress disorder (PTSD). Post-traumatic stress disorder is a severe and heterogeneous disorder with fluctuating states of emotional over- and undermodulation, including hypervigilance, dissociation...

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Autores principales:	Marius Schmitz, Laura E. Müller, Katja I. Seitz, André Schulz, Sylvia Steinmann, Sabine C. Herpertz, Katja Bertsch
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	early life maltreatment post-traumatic stress disorder interoception dissociation mindfulness Psychiatry RC435-571
Acceso en línea:	https://doaj.org/article/f8a901d1085f4e088fd2ebf63ec4b16d
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spelling	oai:doaj.org-article:f8a901d1085f4e088fd2ebf63ec4b16d2021-12-01T14:40:59ZHeartbeat evoked potentials in patients with post-traumatic stress disorder: an unaltered neurobiological regulation system?2000-806610.1080/20008198.2021.1987686https://doaj.org/article/f8a901d1085f4e088fd2ebf63ec4b16d2021-01-01T00:00:00Zhttp://dx.doi.org/10.1080/20008198.2021.1987686https://doaj.org/toc/2000-8066Background Early life maltreatment is a risk factor for psychiatric disorders, including post-traumatic stress disorder (PTSD). Post-traumatic stress disorder is a severe and heterogeneous disorder with fluctuating states of emotional over- and undermodulation, including hypervigilance, dissociation, and emotion regulation deficits. The perception and regulation of emotions have been linked to interoception, the cortical representation and sensing of inner bodily processes. Although first therapeutic approaches targeting bodily sensations have been found effective in patients with PTSD, and deficits in interoceptive signal representation have been reported in other trauma-related disorders, such as borderline personality disorder (BPD), the role of interoception remains largely unexplored for PTSD. Objective The objective was to investigate the cortical representation of cardiac interoceptive signals in patients with PTSD and its associations with early life maltreatment, trait dissociation, and emotion dysregulation. Methods Twenty-four medication-free patients with PTSD and 31 healthy controls (HC) completed a 5-min resting electrocardiogram (ECG) with parallel electroencephalogram (EEG). Heartbeat evoked potential (HEP) amplitudes as a measure for cortical representation of cardiac interoceptive signals were compared between groups and correlated with self-report questionnaires. Results We did not find significantly different mean HEP amplitudes in patients with PTSD compared to HC, although HEPs of patients with PTSD were descriptively higher. No significant associations between mean HEP amplitudes and early life maltreatment, trait dissociation or emotion dysregulation were obtained within the groups. Conclusion The current finding does not indicate deficits in interoceptive signal representation at rest in individuals with PTSD. Whether patients with PTSD show altered HEP modulations during emotion regulation tasks and might benefit from therapeutic approaches aiming at changing the perception of bodily signals, needs to be investigated in future studies.Marius SchmitzLaura E. MüllerKatja I. SeitzAndré SchulzSylvia SteinmannSabine C. HerpertzKatja BertschTaylor & Francis Grouparticleearly life maltreatmentpost-traumatic stress disorderinteroceptiondissociationmindfulnessPsychiatryRC435-571ENEuropean Journal of Psychotraumatology, Vol 12, Iss 1 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	early life maltreatment post-traumatic stress disorder interoception dissociation mindfulness Psychiatry RC435-571
spellingShingle	early life maltreatment post-traumatic stress disorder interoception dissociation mindfulness Psychiatry RC435-571 Marius Schmitz Laura E. Müller Katja I. Seitz André Schulz Sylvia Steinmann Sabine C. Herpertz Katja Bertsch Heartbeat evoked potentials in patients with post-traumatic stress disorder: an unaltered neurobiological regulation system?
description	Background Early life maltreatment is a risk factor for psychiatric disorders, including post-traumatic stress disorder (PTSD). Post-traumatic stress disorder is a severe and heterogeneous disorder with fluctuating states of emotional over- and undermodulation, including hypervigilance, dissociation, and emotion regulation deficits. The perception and regulation of emotions have been linked to interoception, the cortical representation and sensing of inner bodily processes. Although first therapeutic approaches targeting bodily sensations have been found effective in patients with PTSD, and deficits in interoceptive signal representation have been reported in other trauma-related disorders, such as borderline personality disorder (BPD), the role of interoception remains largely unexplored for PTSD. Objective The objective was to investigate the cortical representation of cardiac interoceptive signals in patients with PTSD and its associations with early life maltreatment, trait dissociation, and emotion dysregulation. Methods Twenty-four medication-free patients with PTSD and 31 healthy controls (HC) completed a 5-min resting electrocardiogram (ECG) with parallel electroencephalogram (EEG). Heartbeat evoked potential (HEP) amplitudes as a measure for cortical representation of cardiac interoceptive signals were compared between groups and correlated with self-report questionnaires. Results We did not find significantly different mean HEP amplitudes in patients with PTSD compared to HC, although HEPs of patients with PTSD were descriptively higher. No significant associations between mean HEP amplitudes and early life maltreatment, trait dissociation or emotion dysregulation were obtained within the groups. Conclusion The current finding does not indicate deficits in interoceptive signal representation at rest in individuals with PTSD. Whether patients with PTSD show altered HEP modulations during emotion regulation tasks and might benefit from therapeutic approaches aiming at changing the perception of bodily signals, needs to be investigated in future studies.
format	article
author	Marius Schmitz Laura E. Müller Katja I. Seitz André Schulz Sylvia Steinmann Sabine C. Herpertz Katja Bertsch
author_facet	Marius Schmitz Laura E. Müller Katja I. Seitz André Schulz Sylvia Steinmann Sabine C. Herpertz Katja Bertsch
author_sort	Marius Schmitz
title	Heartbeat evoked potentials in patients with post-traumatic stress disorder: an unaltered neurobiological regulation system?
title_short	Heartbeat evoked potentials in patients with post-traumatic stress disorder: an unaltered neurobiological regulation system?
title_full	Heartbeat evoked potentials in patients with post-traumatic stress disorder: an unaltered neurobiological regulation system?
title_fullStr	Heartbeat evoked potentials in patients with post-traumatic stress disorder: an unaltered neurobiological regulation system?
title_full_unstemmed	Heartbeat evoked potentials in patients with post-traumatic stress disorder: an unaltered neurobiological regulation system?
title_sort	heartbeat evoked potentials in patients with post-traumatic stress disorder: an unaltered neurobiological regulation system?
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/f8a901d1085f4e088fd2ebf63ec4b16d
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Heartbeat evoked potentials in patients with post-traumatic stress disorder: an unaltered neurobiological regulation system?

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