Real-world evidence and optimization of vocal dysfunction in end-stage renal disease patients with secondary hyperparathyroidism

Abstract Patients with end-stage renal disease (ESRD) may demonstrate secondary hyperparathyroidism (SHPT), characterized by parathyroid hormone oversecretion in response to electrolyte imbalance (e.g., hypocalcemia and hyperphosphatemia). Moreover, this electrolyte imbalance may affect vocal cord m...

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Autores principales:	Geng-He Chang, Fong-Fu Chou, Ming-Shao Tsai, Yao-Te Tsai, Ming-Yu Yang, Ethan I. Huang, Hui-Chen Su, Cheng-Ming Hsu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f8ab993fc51d4c8aba10667a6157a0d1
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spelling	oai:doaj.org-article:f8ab993fc51d4c8aba10667a6157a0d12021-12-02T14:02:33ZReal-world evidence and optimization of vocal dysfunction in end-stage renal disease patients with secondary hyperparathyroidism10.1038/s41598-020-79810-02045-2322https://doaj.org/article/f8ab993fc51d4c8aba10667a6157a0d12021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79810-0https://doaj.org/toc/2045-2322Abstract Patients with end-stage renal disease (ESRD) may demonstrate secondary hyperparathyroidism (SHPT), characterized by parathyroid hormone oversecretion in response to electrolyte imbalance (e.g., hypocalcemia and hyperphosphatemia). Moreover, this electrolyte imbalance may affect vocal cord muscle contraction and lead to voice change. Here, we explored the effects of SHPT on the voices of patients with ESRD. We used data of 147,026 patients with ESRD from the registry for catastrophic illness patients, a sub-database of Taiwan National Health Insurance Research Database. We divided these patients into 2 groups based on whether they had hyperparathyroidism (HPT) and compared vocal dysfunction (VD) incidence among them. We also prospectively included 60 ESRD patients with SHPT; 45 of them underwent parathyroidectomy. Preoperatively and postoperatively, voice analysis was used to investigate changes in vocal parameters. In the real-world database analysis, the presence of HPT significantly increased VD incidence in patients with ESRD (p = 0.003): Cox regression analysis results indicated that patients with ESRD had an approximately 1.6-fold increased VD risk (p = 0.003). In the clinical analysis, the “jitter” and “shimmer” factors improved significantly after operation, whereas the aerodynamic factors remained unchanged. In conclusion, SHPT was an independent risk factor for VD in patients with ESRD, mainly affecting their acoustic factors.Geng-He ChangFong-Fu ChouMing-Shao TsaiYao-Te TsaiMing-Yu YangEthan I. HuangHui-Chen SuCheng-Ming HsuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Geng-He Chang Fong-Fu Chou Ming-Shao Tsai Yao-Te Tsai Ming-Yu Yang Ethan I. Huang Hui-Chen Su Cheng-Ming Hsu Real-world evidence and optimization of vocal dysfunction in end-stage renal disease patients with secondary hyperparathyroidism
description	Abstract Patients with end-stage renal disease (ESRD) may demonstrate secondary hyperparathyroidism (SHPT), characterized by parathyroid hormone oversecretion in response to electrolyte imbalance (e.g., hypocalcemia and hyperphosphatemia). Moreover, this electrolyte imbalance may affect vocal cord muscle contraction and lead to voice change. Here, we explored the effects of SHPT on the voices of patients with ESRD. We used data of 147,026 patients with ESRD from the registry for catastrophic illness patients, a sub-database of Taiwan National Health Insurance Research Database. We divided these patients into 2 groups based on whether they had hyperparathyroidism (HPT) and compared vocal dysfunction (VD) incidence among them. We also prospectively included 60 ESRD patients with SHPT; 45 of them underwent parathyroidectomy. Preoperatively and postoperatively, voice analysis was used to investigate changes in vocal parameters. In the real-world database analysis, the presence of HPT significantly increased VD incidence in patients with ESRD (p = 0.003): Cox regression analysis results indicated that patients with ESRD had an approximately 1.6-fold increased VD risk (p = 0.003). In the clinical analysis, the “jitter” and “shimmer” factors improved significantly after operation, whereas the aerodynamic factors remained unchanged. In conclusion, SHPT was an independent risk factor for VD in patients with ESRD, mainly affecting their acoustic factors.
format	article
author	Geng-He Chang Fong-Fu Chou Ming-Shao Tsai Yao-Te Tsai Ming-Yu Yang Ethan I. Huang Hui-Chen Su Cheng-Ming Hsu
author_facet	Geng-He Chang Fong-Fu Chou Ming-Shao Tsai Yao-Te Tsai Ming-Yu Yang Ethan I. Huang Hui-Chen Su Cheng-Ming Hsu
author_sort	Geng-He Chang
title	Real-world evidence and optimization of vocal dysfunction in end-stage renal disease patients with secondary hyperparathyroidism
title_short	Real-world evidence and optimization of vocal dysfunction in end-stage renal disease patients with secondary hyperparathyroidism
title_full	Real-world evidence and optimization of vocal dysfunction in end-stage renal disease patients with secondary hyperparathyroidism
title_fullStr	Real-world evidence and optimization of vocal dysfunction in end-stage renal disease patients with secondary hyperparathyroidism
title_full_unstemmed	Real-world evidence and optimization of vocal dysfunction in end-stage renal disease patients with secondary hyperparathyroidism
title_sort	real-world evidence and optimization of vocal dysfunction in end-stage renal disease patients with secondary hyperparathyroidism
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/f8ab993fc51d4c8aba10667a6157a0d1
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Real-world evidence and optimization of vocal dysfunction in end-stage renal disease patients with secondary hyperparathyroidism

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