CpG methylation changes within the IL2RA promoter in type 1 diabetes of childhood onset.

None of the polymorphic variants of the IL2RA gene found associated with Type 1 Diabetes (T1D) was shown to have a functional effect. To test if the epigenetic variation could play a role at this locus, we studied the methylation of 6 CpGs located within the proximal promoter of IL2RA gene in 252 T1...

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Autores principales:	Marie-Pierre Belot, Delphine Fradin, Nga Mai, Sophie Le Fur, Diana Zélénika, Julie Kerr-Conte, François Pattou, Bruno Lucas, Pierre Bougnères
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f8b224860e7c4313b520da53d9cad5f4
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spelling	oai:doaj.org-article:f8b224860e7c4313b520da53d9cad5f42021-11-18T07:37:45ZCpG methylation changes within the IL2RA promoter in type 1 diabetes of childhood onset.1932-620310.1371/journal.pone.0068093https://doaj.org/article/f8b224860e7c4313b520da53d9cad5f42013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23874506/?tool=EBIhttps://doaj.org/toc/1932-6203None of the polymorphic variants of the IL2RA gene found associated with Type 1 Diabetes (T1D) was shown to have a functional effect. To test if the epigenetic variation could play a role at this locus, we studied the methylation of 6 CpGs located within the proximal promoter of IL2RA gene in 252 T1D patients compared with 286 age-matched controls. We found that DNA methylation at CpGs -373 and -456 was slightly but significantly higher in patients than in controls (40.4 ± 4.6 vs 38.3 ± 5.4, p=1.4E4; 91.4 ± 2.8 vs 89.5 ± 5.3, p=1.8E-6), while other CpG showed a strictly comparable methylation. Among 106 single nucleotide polymorphisms (SNPs) located in the neighboring 180 kb region, we found that 28 SNPs were associated with DNA methylation at CpG -373. Sixteen of these SNPs were known to be associated with T1D. Our findings suggest that the effect of IL2RA risk alleles on T1D may be partially mediated through epigenetic changes.Marie-Pierre BelotDelphine FradinNga MaiSophie Le FurDiana ZélénikaJulie Kerr-ConteFrançois PattouBruno LucasPierre BougnèresPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 7, p e68093 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marie-Pierre Belot Delphine Fradin Nga Mai Sophie Le Fur Diana Zélénika Julie Kerr-Conte François Pattou Bruno Lucas Pierre Bougnères CpG methylation changes within the IL2RA promoter in type 1 diabetes of childhood onset.
description	None of the polymorphic variants of the IL2RA gene found associated with Type 1 Diabetes (T1D) was shown to have a functional effect. To test if the epigenetic variation could play a role at this locus, we studied the methylation of 6 CpGs located within the proximal promoter of IL2RA gene in 252 T1D patients compared with 286 age-matched controls. We found that DNA methylation at CpGs -373 and -456 was slightly but significantly higher in patients than in controls (40.4 ± 4.6 vs 38.3 ± 5.4, p=1.4E4; 91.4 ± 2.8 vs 89.5 ± 5.3, p=1.8E-6), while other CpG showed a strictly comparable methylation. Among 106 single nucleotide polymorphisms (SNPs) located in the neighboring 180 kb region, we found that 28 SNPs were associated with DNA methylation at CpG -373. Sixteen of these SNPs were known to be associated with T1D. Our findings suggest that the effect of IL2RA risk alleles on T1D may be partially mediated through epigenetic changes.
format	article
author	Marie-Pierre Belot Delphine Fradin Nga Mai Sophie Le Fur Diana Zélénika Julie Kerr-Conte François Pattou Bruno Lucas Pierre Bougnères
author_facet	Marie-Pierre Belot Delphine Fradin Nga Mai Sophie Le Fur Diana Zélénika Julie Kerr-Conte François Pattou Bruno Lucas Pierre Bougnères
author_sort	Marie-Pierre Belot
title	CpG methylation changes within the IL2RA promoter in type 1 diabetes of childhood onset.
title_short	CpG methylation changes within the IL2RA promoter in type 1 diabetes of childhood onset.
title_full	CpG methylation changes within the IL2RA promoter in type 1 diabetes of childhood onset.
title_fullStr	CpG methylation changes within the IL2RA promoter in type 1 diabetes of childhood onset.
title_full_unstemmed	CpG methylation changes within the IL2RA promoter in type 1 diabetes of childhood onset.
title_sort	cpg methylation changes within the il2ra promoter in type 1 diabetes of childhood onset.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/f8b224860e7c4313b520da53d9cad5f4
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CpG methylation changes within the IL2RA promoter in type 1 diabetes of childhood onset.

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