CpG methylation changes within the IL2RA promoter in type 1 diabetes of childhood onset.

CpG methylation changes within the IL2RA promoter in type 1 diabetes of childhood onset.

None of the polymorphic variants of the IL2RA gene found associated with Type 1 Diabetes (T1D) was shown to have a functional effect. To test if the epigenetic variation could play a role at this locus, we studied the methylation of 6 CpGs located within the proximal promoter of IL2RA gene in 252 T1...

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Main Authors: Marie-Pierre Belot, Delphine Fradin, Nga Mai, Sophie Le Fur, Diana Zélénika, Julie Kerr-Conte, François Pattou, Bruno Lucas, Pierre Bougnères
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2013
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/f8b224860e7c4313b520da53d9cad5f4
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