Reprogramming, oscillations and transdifferentiation in epigenetic landscapes

Abstract Waddington’s epigenetic landscape provides a phenomenological understanding of the cell differentiation pathways from the pluripotent to mature lineage-committed cell lines. In light of recent successes in the reverse programming process there has been significant interest in quantifying th...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Bivash Kaity, Ratan Sarkar, Buddhapriya Chakrabarti, Mithun K. Mitra
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f8b3e1c4808b4fb79527852698d4d61f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:f8b3e1c4808b4fb79527852698d4d61f
record_format	dspace
spelling	oai:doaj.org-article:f8b3e1c4808b4fb79527852698d4d61f2021-12-02T15:08:26ZReprogramming, oscillations and transdifferentiation in epigenetic landscapes10.1038/s41598-018-25556-92045-2322https://doaj.org/article/f8b3e1c4808b4fb79527852698d4d61f2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-25556-9https://doaj.org/toc/2045-2322Abstract Waddington’s epigenetic landscape provides a phenomenological understanding of the cell differentiation pathways from the pluripotent to mature lineage-committed cell lines. In light of recent successes in the reverse programming process there has been significant interest in quantifying the underlying landscape picture through the mathematics of gene regulatory networks. We investigate the role of time delays arising from multi-step chemical reactions and epigenetic rearrangement on the cell differentiation landscape for a realistic two-gene regulatory network, consisting of self-promoting and mutually inhibiting genes. Our work provides the first theoretical basis of the transdifferentiation process in the presence of delays, where one differentiated cell type can transition to another directly without passing through the undifferentiated state. Additionally, the interplay of time-delayed feedback and a time dependent chemical drive leads to long-lived oscillatory states in appropriate parameter regimes. This work emphasizes the important role played by time-delayed feedback loops in gene regulatory circuits and provides a framework for the characterization of epigenetic landscapes.Bivash KaityRatan SarkarBuddhapriya ChakrabartiMithun K. MitraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Bivash Kaity Ratan Sarkar Buddhapriya Chakrabarti Mithun K. Mitra Reprogramming, oscillations and transdifferentiation in epigenetic landscapes
description	Abstract Waddington’s epigenetic landscape provides a phenomenological understanding of the cell differentiation pathways from the pluripotent to mature lineage-committed cell lines. In light of recent successes in the reverse programming process there has been significant interest in quantifying the underlying landscape picture through the mathematics of gene regulatory networks. We investigate the role of time delays arising from multi-step chemical reactions and epigenetic rearrangement on the cell differentiation landscape for a realistic two-gene regulatory network, consisting of self-promoting and mutually inhibiting genes. Our work provides the first theoretical basis of the transdifferentiation process in the presence of delays, where one differentiated cell type can transition to another directly without passing through the undifferentiated state. Additionally, the interplay of time-delayed feedback and a time dependent chemical drive leads to long-lived oscillatory states in appropriate parameter regimes. This work emphasizes the important role played by time-delayed feedback loops in gene regulatory circuits and provides a framework for the characterization of epigenetic landscapes.
format	article
author	Bivash Kaity Ratan Sarkar Buddhapriya Chakrabarti Mithun K. Mitra
author_facet	Bivash Kaity Ratan Sarkar Buddhapriya Chakrabarti Mithun K. Mitra
author_sort	Bivash Kaity
title	Reprogramming, oscillations and transdifferentiation in epigenetic landscapes
title_short	Reprogramming, oscillations and transdifferentiation in epigenetic landscapes
title_full	Reprogramming, oscillations and transdifferentiation in epigenetic landscapes
title_fullStr	Reprogramming, oscillations and transdifferentiation in epigenetic landscapes
title_full_unstemmed	Reprogramming, oscillations and transdifferentiation in epigenetic landscapes
title_sort	reprogramming, oscillations and transdifferentiation in epigenetic landscapes
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/f8b3e1c4808b4fb79527852698d4d61f
work_keys_str_mv	AT bivashkaity reprogrammingoscillationsandtransdifferentiationinepigeneticlandscapes AT ratansarkar reprogrammingoscillationsandtransdifferentiationinepigeneticlandscapes AT buddhapriyachakrabarti reprogrammingoscillationsandtransdifferentiationinepigeneticlandscapes AT mithunkmitra reprogrammingoscillationsandtransdifferentiationinepigeneticlandscapes
_version_	1718388164328947712

Reprogramming, oscillations and transdifferentiation in epigenetic landscapes

Ejemplares similares