Structural and functional consequences of the STAT5BN642H driver mutation

Hyper-activated STAT5B and its disease-causing variants are of interest as cancer drug targets. Here the authors combine cell based studies, X-ray crystallography, biophysical experiments and MD simulations to structurally and functionally characterize the STAT5BN642H mutant found in aggressive T-ce...

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Autores principales:	Elvin D. de Araujo, Fettah Erdogan, Heidi A. Neubauer, Deniz Meneksedag-Erol, Pimyupa Manaswiyoungkul, Mohammad S. Eram, Hyuk-Soo Seo, Abdul K. Qadree, Johan Israelian, Anna Orlova, Tobias Suske, Ha T. T. Pham, Auke Boersma, Simone Tangermann, Lukas Kenner, Thomas Rülicke, Aiping Dong, Manimekalai Ravichandran, Peter J. Brown, Gerald F. Audette, Sarah Rauscher, Sirano Dhe-Paganon, Richard Moriggl, Patrick T. Gunning
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f8b672c48f8f4b91911646f53ce84f0b
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spelling	oai:doaj.org-article:f8b672c48f8f4b91911646f53ce84f0b2021-12-02T16:57:08ZStructural and functional consequences of the STAT5BN642H driver mutation10.1038/s41467-019-10422-72041-1723https://doaj.org/article/f8b672c48f8f4b91911646f53ce84f0b2019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10422-7https://doaj.org/toc/2041-1723Hyper-activated STAT5B and its disease-causing variants are of interest as cancer drug targets. Here the authors combine cell based studies, X-ray crystallography, biophysical experiments and MD simulations to structurally and functionally characterize the STAT5BN642H mutant found in aggressive T-cell leukemia and lymphomas and find that it has an increased affinity for self-dimerization.Elvin D. de AraujoFettah ErdoganHeidi A. NeubauerDeniz Meneksedag-ErolPimyupa ManaswiyoungkulMohammad S. EramHyuk-Soo SeoAbdul K. QadreeJohan IsraelianAnna OrlovaTobias SuskeHa T. T. PhamAuke BoersmaSimone TangermannLukas KennerThomas RülickeAiping DongManimekalai RavichandranPeter J. BrownGerald F. AudetteSarah RauscherSirano Dhe-PaganonRichard MorigglPatrick T. GunningNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Elvin D. de Araujo Fettah Erdogan Heidi A. Neubauer Deniz Meneksedag-Erol Pimyupa Manaswiyoungkul Mohammad S. Eram Hyuk-Soo Seo Abdul K. Qadree Johan Israelian Anna Orlova Tobias Suske Ha T. T. Pham Auke Boersma Simone Tangermann Lukas Kenner Thomas Rülicke Aiping Dong Manimekalai Ravichandran Peter J. Brown Gerald F. Audette Sarah Rauscher Sirano Dhe-Paganon Richard Moriggl Patrick T. Gunning Structural and functional consequences of the STAT5BN642H driver mutation
description	Hyper-activated STAT5B and its disease-causing variants are of interest as cancer drug targets. Here the authors combine cell based studies, X-ray crystallography, biophysical experiments and MD simulations to structurally and functionally characterize the STAT5BN642H mutant found in aggressive T-cell leukemia and lymphomas and find that it has an increased affinity for self-dimerization.
format	article
author	Elvin D. de Araujo Fettah Erdogan Heidi A. Neubauer Deniz Meneksedag-Erol Pimyupa Manaswiyoungkul Mohammad S. Eram Hyuk-Soo Seo Abdul K. Qadree Johan Israelian Anna Orlova Tobias Suske Ha T. T. Pham Auke Boersma Simone Tangermann Lukas Kenner Thomas Rülicke Aiping Dong Manimekalai Ravichandran Peter J. Brown Gerald F. Audette Sarah Rauscher Sirano Dhe-Paganon Richard Moriggl Patrick T. Gunning
author_facet	Elvin D. de Araujo Fettah Erdogan Heidi A. Neubauer Deniz Meneksedag-Erol Pimyupa Manaswiyoungkul Mohammad S. Eram Hyuk-Soo Seo Abdul K. Qadree Johan Israelian Anna Orlova Tobias Suske Ha T. T. Pham Auke Boersma Simone Tangermann Lukas Kenner Thomas Rülicke Aiping Dong Manimekalai Ravichandran Peter J. Brown Gerald F. Audette Sarah Rauscher Sirano Dhe-Paganon Richard Moriggl Patrick T. Gunning
author_sort	Elvin D. de Araujo
title	Structural and functional consequences of the STAT5BN642H driver mutation
title_short	Structural and functional consequences of the STAT5BN642H driver mutation
title_full	Structural and functional consequences of the STAT5BN642H driver mutation
title_fullStr	Structural and functional consequences of the STAT5BN642H driver mutation
title_full_unstemmed	Structural and functional consequences of the STAT5BN642H driver mutation
title_sort	structural and functional consequences of the stat5bn642h driver mutation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/f8b672c48f8f4b91911646f53ce84f0b
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Structural and functional consequences of the STAT5BN642H driver mutation

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