Structural insights into substrate and inhibitor binding sites in human indoleamine 2,3-dioxygenase 1

Human indoleamine 2,3-dioxygenase 1 (hIDO1) is an immunotherapeutic target for cancer therapy. Here, the authors present the substrate-, inhibitor- and effector-bound hIDO1 crystal structures, which give insights into the mechanism and reveal a second small molecule binding site, which is of interes...

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Autores principales:	Ariel Lewis-Ballester, Khoa N. Pham, Dipanwita Batabyal, Shay Karkashon, Jeffrey B. Bonanno, Thomas L. Poulos, Syun-Ru Yeh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/f8b733a4df2546f48fc72aa65deeac3d
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spelling	oai:doaj.org-article:f8b733a4df2546f48fc72aa65deeac3d2021-12-02T14:43:00ZStructural insights into substrate and inhibitor binding sites in human indoleamine 2,3-dioxygenase 110.1038/s41467-017-01725-82041-1723https://doaj.org/article/f8b733a4df2546f48fc72aa65deeac3d2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01725-8https://doaj.org/toc/2041-1723Human indoleamine 2,3-dioxygenase 1 (hIDO1) is an immunotherapeutic target for cancer therapy. Here, the authors present the substrate-, inhibitor- and effector-bound hIDO1 crystal structures, which give insights into the mechanism and reveal a second small molecule binding site, which is of interest for drug design.Ariel Lewis-BallesterKhoa N. PhamDipanwita BatabyalShay KarkashonJeffrey B. BonannoThomas L. PoulosSyun-Ru YehNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ariel Lewis-Ballester Khoa N. Pham Dipanwita Batabyal Shay Karkashon Jeffrey B. Bonanno Thomas L. Poulos Syun-Ru Yeh Structural insights into substrate and inhibitor binding sites in human indoleamine 2,3-dioxygenase 1
description	Human indoleamine 2,3-dioxygenase 1 (hIDO1) is an immunotherapeutic target for cancer therapy. Here, the authors present the substrate-, inhibitor- and effector-bound hIDO1 crystal structures, which give insights into the mechanism and reveal a second small molecule binding site, which is of interest for drug design.
format	article
author	Ariel Lewis-Ballester Khoa N. Pham Dipanwita Batabyal Shay Karkashon Jeffrey B. Bonanno Thomas L. Poulos Syun-Ru Yeh
author_facet	Ariel Lewis-Ballester Khoa N. Pham Dipanwita Batabyal Shay Karkashon Jeffrey B. Bonanno Thomas L. Poulos Syun-Ru Yeh
author_sort	Ariel Lewis-Ballester
title	Structural insights into substrate and inhibitor binding sites in human indoleamine 2,3-dioxygenase 1
title_short	Structural insights into substrate and inhibitor binding sites in human indoleamine 2,3-dioxygenase 1
title_full	Structural insights into substrate and inhibitor binding sites in human indoleamine 2,3-dioxygenase 1
title_fullStr	Structural insights into substrate and inhibitor binding sites in human indoleamine 2,3-dioxygenase 1
title_full_unstemmed	Structural insights into substrate and inhibitor binding sites in human indoleamine 2,3-dioxygenase 1
title_sort	structural insights into substrate and inhibitor binding sites in human indoleamine 2,3-dioxygenase 1
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f8b733a4df2546f48fc72aa65deeac3d
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_version_	1718389607695908864

Structural insights into substrate and inhibitor binding sites in human indoleamine 2,3-dioxygenase 1

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