An L-Shaped Relationship Between Serum Iron and Stroke-Associated Pneumonia

Jia Li,1 Liang Feng,1 Qiqi Huang,2 Wenwei Ren1 1Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, People’s Republic of China; 2Department of Cardiac Care Unit, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000,...

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Autores principales:	Li J, Feng L, Huang Q, Ren W
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	stroke pneumonia serum iron Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/f8b883e70ecd40b3b029d3eb984e7821
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spelling	oai:doaj.org-article:f8b883e70ecd40b3b029d3eb984e78212021-12-02T17:06:25ZAn L-Shaped Relationship Between Serum Iron and Stroke-Associated Pneumonia1178-1998https://doaj.org/article/f8b883e70ecd40b3b029d3eb984e78212021-03-01T00:00:00Zhttps://www.dovepress.com/an-l-shaped-relationship-between-serum-iron-and-stroke-associated-pneu-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Jia Li,1 Liang Feng,1 Qiqi Huang,2 Wenwei Ren1 1Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, People’s Republic of China; 2Department of Cardiac Care Unit, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, People’s Republic of ChinaCorrespondence: Wenwei RenDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang Province, People’s Republic of ChinaTel/Fax +86 577 555 54543Email rww037@126.comQiqi HuangDepartment of Cardiac Care Unit, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang Province, People’s Republic of ChinaTel/Fax +86 577 555 54543Email wyyyhqq@126.comObjective: Pneumonia is a common complication in patients with stroke. There was a close relationship between serum iron and inflammatory response. This study aimed to explore the relationship between serum iron levels and stroke-associated pneumonia (SAP).Methods: Patients with acute stroke were recruited from the First Affiliated Hospital of Wenzhou Medical University and divided into SAP group and Non-SAP group. The demographic and clinical data of the patients were collected via the medical records, and the blood samples were collected within 24 hours after admission. The predictive value of serum iron to SAP was evaluated by receiver operating characteristic curve (ROC) and binary Logistic regression models. A restricted cubic spline (RCS) was used to furtherly clarify the relationship between serum iron and the risk of SAP.Results: A total of 906 participants were enrolled, including Non-SAP group (n = 755) and SAP group (n = 151). Serum iron levels in the SAP group were significantly lower than those in the Non-SAP group (9.77± 5.61 vs 14.01± 6.80, P < 0.001). Logistic regression showed that patients with high serum iron levels (≥ 7.8μmol/L) showed a lower risk of SAP (OR=0.43, 95% CI, 0.27– 0.69, P < 0.001). Besides, the RCS model showed that there was an L-shaped relationship between the serum iron and risk of SAP (P for non-linearity: 0.014).Conclusion: Low serum iron level was a risk factor for SAP, and there was an L-shaped relationship between them. Stroke patients with low serum iron levels should be alert to the risk of SAP.Keywords: stroke, pneumonia, serum ironLi JFeng LHuang QRen WDove Medical Pressarticlestrokepneumoniaserum ironGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 16, Pp 505-511 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	stroke pneumonia serum iron Geriatrics RC952-954.6
spellingShingle	stroke pneumonia serum iron Geriatrics RC952-954.6 Li J Feng L Huang Q Ren W An L-Shaped Relationship Between Serum Iron and Stroke-Associated Pneumonia
description	Jia Li,1 Liang Feng,1 Qiqi Huang,2 Wenwei Ren1 1Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, People’s Republic of China; 2Department of Cardiac Care Unit, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, People’s Republic of ChinaCorrespondence: Wenwei RenDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang Province, People’s Republic of ChinaTel/Fax +86 577 555 54543Email rww037@126.comQiqi HuangDepartment of Cardiac Care Unit, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang Province, People’s Republic of ChinaTel/Fax +86 577 555 54543Email wyyyhqq@126.comObjective: Pneumonia is a common complication in patients with stroke. There was a close relationship between serum iron and inflammatory response. This study aimed to explore the relationship between serum iron levels and stroke-associated pneumonia (SAP).Methods: Patients with acute stroke were recruited from the First Affiliated Hospital of Wenzhou Medical University and divided into SAP group and Non-SAP group. The demographic and clinical data of the patients were collected via the medical records, and the blood samples were collected within 24 hours after admission. The predictive value of serum iron to SAP was evaluated by receiver operating characteristic curve (ROC) and binary Logistic regression models. A restricted cubic spline (RCS) was used to furtherly clarify the relationship between serum iron and the risk of SAP.Results: A total of 906 participants were enrolled, including Non-SAP group (n = 755) and SAP group (n = 151). Serum iron levels in the SAP group were significantly lower than those in the Non-SAP group (9.77± 5.61 vs 14.01± 6.80, P < 0.001). Logistic regression showed that patients with high serum iron levels (≥ 7.8μmol/L) showed a lower risk of SAP (OR=0.43, 95% CI, 0.27– 0.69, P < 0.001). Besides, the RCS model showed that there was an L-shaped relationship between the serum iron and risk of SAP (P for non-linearity: 0.014).Conclusion: Low serum iron level was a risk factor for SAP, and there was an L-shaped relationship between them. Stroke patients with low serum iron levels should be alert to the risk of SAP.Keywords: stroke, pneumonia, serum iron
format	article
author	Li J Feng L Huang Q Ren W
author_facet	Li J Feng L Huang Q Ren W
author_sort	Li J
title	An L-Shaped Relationship Between Serum Iron and Stroke-Associated Pneumonia
title_short	An L-Shaped Relationship Between Serum Iron and Stroke-Associated Pneumonia
title_full	An L-Shaped Relationship Between Serum Iron and Stroke-Associated Pneumonia
title_fullStr	An L-Shaped Relationship Between Serum Iron and Stroke-Associated Pneumonia
title_full_unstemmed	An L-Shaped Relationship Between Serum Iron and Stroke-Associated Pneumonia
title_sort	l-shaped relationship between serum iron and stroke-associated pneumonia
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/f8b883e70ecd40b3b029d3eb984e7821
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_version_	1718381652069056512

An L-Shaped Relationship Between Serum Iron and Stroke-Associated Pneumonia

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