Natural killer cell activation contributes to hepatitis B viral control in a mouse model

Abstract The roles of CD4 + T cells and CD8 + T cells in hepatitis B virus (HBV) infection have been well documented. However, the role of innate immunity in HBV infection remains obscure. Here we examined the effect of activation of innate immunity by polyinosinic: polycytidylic acid (PolyI:C) on H...

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Autores principales:	Shiwen Tong, Guangze Liu, Minghong Li, Xiumei Li, Qian Liu, Hong Peng, Shiying Li, Hong Ren, Wenwei Yin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f8bde878c43741498a7c45fb67c848ef
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spelling	oai:doaj.org-article:f8bde878c43741498a7c45fb67c848ef2021-12-02T16:08:01ZNatural killer cell activation contributes to hepatitis B viral control in a mouse model10.1038/s41598-017-00387-22045-2322https://doaj.org/article/f8bde878c43741498a7c45fb67c848ef2017-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00387-2https://doaj.org/toc/2045-2322Abstract The roles of CD4 + T cells and CD8 + T cells in hepatitis B virus (HBV) infection have been well documented. However, the role of innate immunity in HBV infection remains obscure. Here we examined the effect of activation of innate immunity by polyinosinic: polycytidylic acid (PolyI:C) on HBV infection. A chronic HBV replication mouse model was established by hydrodynamical injection of pAAV/HBV1.2 plasmid into C57BL/6 mice. We found that HBV did not seem to induce an active NK-cell response in the mouse model. Early PolyI:C treatment markedly decreased serum HBV levels and led to HBV clearance. Following PolyI:C injection, NK cells were activated and accumulated in the liver. Depletion of NK cells markedly attenuated the anti-HBV activity of PolyI:C. Moreover, we found that IFN-γ production from NK cells was essential for the antiviral effect of PolyI:C in the model. Importantly, activation of NK cells by PolyI:C could also lead to HBV suppression in HBV-tolerant mice and HBV-transgenic mice. These results suggest that activated NK cells might suppress HBV and contribute to HBV clearance during natural HBV infection. In addition, therapeutic activation of NK cells may represent a new strategy for the treatment of chronic HBV infection.Shiwen TongGuangze LiuMinghong LiXiumei LiQian LiuHong PengShiying LiHong RenWenwei YinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shiwen Tong Guangze Liu Minghong Li Xiumei Li Qian Liu Hong Peng Shiying Li Hong Ren Wenwei Yin Natural killer cell activation contributes to hepatitis B viral control in a mouse model
description	Abstract The roles of CD4 + T cells and CD8 + T cells in hepatitis B virus (HBV) infection have been well documented. However, the role of innate immunity in HBV infection remains obscure. Here we examined the effect of activation of innate immunity by polyinosinic: polycytidylic acid (PolyI:C) on HBV infection. A chronic HBV replication mouse model was established by hydrodynamical injection of pAAV/HBV1.2 plasmid into C57BL/6 mice. We found that HBV did not seem to induce an active NK-cell response in the mouse model. Early PolyI:C treatment markedly decreased serum HBV levels and led to HBV clearance. Following PolyI:C injection, NK cells were activated and accumulated in the liver. Depletion of NK cells markedly attenuated the anti-HBV activity of PolyI:C. Moreover, we found that IFN-γ production from NK cells was essential for the antiviral effect of PolyI:C in the model. Importantly, activation of NK cells by PolyI:C could also lead to HBV suppression in HBV-tolerant mice and HBV-transgenic mice. These results suggest that activated NK cells might suppress HBV and contribute to HBV clearance during natural HBV infection. In addition, therapeutic activation of NK cells may represent a new strategy for the treatment of chronic HBV infection.
format	article
author	Shiwen Tong Guangze Liu Minghong Li Xiumei Li Qian Liu Hong Peng Shiying Li Hong Ren Wenwei Yin
author_facet	Shiwen Tong Guangze Liu Minghong Li Xiumei Li Qian Liu Hong Peng Shiying Li Hong Ren Wenwei Yin
author_sort	Shiwen Tong
title	Natural killer cell activation contributes to hepatitis B viral control in a mouse model
title_short	Natural killer cell activation contributes to hepatitis B viral control in a mouse model
title_full	Natural killer cell activation contributes to hepatitis B viral control in a mouse model
title_fullStr	Natural killer cell activation contributes to hepatitis B viral control in a mouse model
title_full_unstemmed	Natural killer cell activation contributes to hepatitis B viral control in a mouse model
title_sort	natural killer cell activation contributes to hepatitis b viral control in a mouse model
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/f8bde878c43741498a7c45fb67c848ef
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Natural killer cell activation contributes to hepatitis B viral control in a mouse model

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