A comparative analysis of longitudinal computed tomography and histopathology for evaluating the potential of mesenchymal stem cells in mitigating radiation-induced pulmonary fibrosis
Abstract Radiation-induced pulmonary fibrosis (RIPF) is a debilitating side effect that occurs in up to 30% of thoracic irradiations in breast and lung cancer patients. RIPF remains a major limiting factor to dose escalation and an obstacle to applying more promising new treatments for cancer cure....
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Nature Portfolio
2017
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oai:doaj.org-article:f8c0c2ff052a4edba2920a77d6b2243d2021-12-02T11:40:20ZA comparative analysis of longitudinal computed tomography and histopathology for evaluating the potential of mesenchymal stem cells in mitigating radiation-induced pulmonary fibrosis10.1038/s41598-017-09021-72045-2322https://doaj.org/article/f8c0c2ff052a4edba2920a77d6b2243d2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-09021-7https://doaj.org/toc/2045-2322Abstract Radiation-induced pulmonary fibrosis (RIPF) is a debilitating side effect that occurs in up to 30% of thoracic irradiations in breast and lung cancer patients. RIPF remains a major limiting factor to dose escalation and an obstacle to applying more promising new treatments for cancer cure. Limited treatment options are available to mitigate RIPF once it occurs, but recently, mesenchymal stem cells (MSCs) and a drug treatment stimulating endogenous stem cells (GM-CSF) have been investigated for their potential in preventing this disease onset. In a pre-clinical rat model, we contrasted the application of longitudinal computed tomography (CT) imaging and classical histopathology to quantify RIPF and to evaluate the potential of MSCs in mitigating RIPF. Our results on histology demonstrate promises when MSCs are injected endotracheally (but not intravenously). While our CT analysis highlights the potential of GM-CSF treatment. Advantages and limitations of both analytical methods are contrasted in the context of RIPF.Jessica R. PerezSangkyu LeeNorma YbarraOla MariaMonica SerbanKrishinima JeyaseelanLi Ming WangJan SeuntjensIssam El NaqaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017) |
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Medicine R Science Q Jessica R. Perez Sangkyu Lee Norma Ybarra Ola Maria Monica Serban Krishinima Jeyaseelan Li Ming Wang Jan Seuntjens Issam El Naqa A comparative analysis of longitudinal computed tomography and histopathology for evaluating the potential of mesenchymal stem cells in mitigating radiation-induced pulmonary fibrosis |
description |
Abstract Radiation-induced pulmonary fibrosis (RIPF) is a debilitating side effect that occurs in up to 30% of thoracic irradiations in breast and lung cancer patients. RIPF remains a major limiting factor to dose escalation and an obstacle to applying more promising new treatments for cancer cure. Limited treatment options are available to mitigate RIPF once it occurs, but recently, mesenchymal stem cells (MSCs) and a drug treatment stimulating endogenous stem cells (GM-CSF) have been investigated for their potential in preventing this disease onset. In a pre-clinical rat model, we contrasted the application of longitudinal computed tomography (CT) imaging and classical histopathology to quantify RIPF and to evaluate the potential of MSCs in mitigating RIPF. Our results on histology demonstrate promises when MSCs are injected endotracheally (but not intravenously). While our CT analysis highlights the potential of GM-CSF treatment. Advantages and limitations of both analytical methods are contrasted in the context of RIPF. |
format |
article |
author |
Jessica R. Perez Sangkyu Lee Norma Ybarra Ola Maria Monica Serban Krishinima Jeyaseelan Li Ming Wang Jan Seuntjens Issam El Naqa |
author_facet |
Jessica R. Perez Sangkyu Lee Norma Ybarra Ola Maria Monica Serban Krishinima Jeyaseelan Li Ming Wang Jan Seuntjens Issam El Naqa |
author_sort |
Jessica R. Perez |
title |
A comparative analysis of longitudinal computed tomography and histopathology for evaluating the potential of mesenchymal stem cells in mitigating radiation-induced pulmonary fibrosis |
title_short |
A comparative analysis of longitudinal computed tomography and histopathology for evaluating the potential of mesenchymal stem cells in mitigating radiation-induced pulmonary fibrosis |
title_full |
A comparative analysis of longitudinal computed tomography and histopathology for evaluating the potential of mesenchymal stem cells in mitigating radiation-induced pulmonary fibrosis |
title_fullStr |
A comparative analysis of longitudinal computed tomography and histopathology for evaluating the potential of mesenchymal stem cells in mitigating radiation-induced pulmonary fibrosis |
title_full_unstemmed |
A comparative analysis of longitudinal computed tomography and histopathology for evaluating the potential of mesenchymal stem cells in mitigating radiation-induced pulmonary fibrosis |
title_sort |
comparative analysis of longitudinal computed tomography and histopathology for evaluating the potential of mesenchymal stem cells in mitigating radiation-induced pulmonary fibrosis |
publisher |
Nature Portfolio |
publishDate |
2017 |
url |
https://doaj.org/article/f8c0c2ff052a4edba2920a77d6b2243d |
work_keys_str_mv |
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