Strain diversity of Treponema pallidum subsp. pertenue suggests rare interspecies transmission in African nonhuman primates

Abstract In our most recent study, we found that in Tanzania infection with Treponema pallidum (TP) subsp. pertenue (TPE) is present in four different monkey species. In order to gain information on the diversity and epidemiological spread of the infection in Tanzanian nonhuman primates (NHP), we id...

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Autores principales:	Idrissa S. Chuma, Christian Roos, Anagaw Atickem, Torsten Bohm, D. Anthony Collins, Linda Grillová, Luisa K. Hallmaier-Wacker, Rudovick R. Kazwala, Julius D. Keyyu, Simone Lüert, Ulrich Maloueki, Jan Oppelt, Klára J. Petrželková, Alexander Piel, Fiona A. Stewart, David Šmajs, Sascha Knauf
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/f8c164691259480489fa429dfbf414e4
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spelling	oai:doaj.org-article:f8c164691259480489fa429dfbf414e42021-12-02T15:08:08ZStrain diversity of Treponema pallidum subsp. pertenue suggests rare interspecies transmission in African nonhuman primates10.1038/s41598-019-50779-92045-2322https://doaj.org/article/f8c164691259480489fa429dfbf414e42019-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-50779-9https://doaj.org/toc/2045-2322Abstract In our most recent study, we found that in Tanzania infection with Treponema pallidum (TP) subsp. pertenue (TPE) is present in four different monkey species. In order to gain information on the diversity and epidemiological spread of the infection in Tanzanian nonhuman primates (NHP), we identified two suitable candidate genes for multi-locus sequence typing (MLST). We demonstrate the functionality of the MLST system in invasively and non-invasively collected samples. While we were not able to demonstrate frequent interspecies transmission of TPE in Tanzanian monkeys, our results show a clustering of TPE strains according to geography and not host species, which is suggestive for rare transmission events between different NHP species. In addition to the geographic stability, we describe the relative temporal stability of the strains infecting NHPs and identified multi-strain infection. Differences between TPE strains of NHP and human origin are highlighted. Our results show that antibiotic resistance does not occur in Tanzanian TPE strains of NHP origin.Idrissa S. ChumaChristian RoosAnagaw AtickemTorsten BohmD. Anthony CollinsLinda GrillováLuisa K. Hallmaier-WackerRudovick R. KazwalaJulius D. KeyyuSimone LüertUlrich MalouekiJan OppeltKlára J. PetrželkováAlexander PielFiona A. StewartDavid ŠmajsSascha KnaufNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Idrissa S. Chuma Christian Roos Anagaw Atickem Torsten Bohm D. Anthony Collins Linda Grillová Luisa K. Hallmaier-Wacker Rudovick R. Kazwala Julius D. Keyyu Simone Lüert Ulrich Maloueki Jan Oppelt Klára J. Petrželková Alexander Piel Fiona A. Stewart David Šmajs Sascha Knauf Strain diversity of Treponema pallidum subsp. pertenue suggests rare interspecies transmission in African nonhuman primates
description	Abstract In our most recent study, we found that in Tanzania infection with Treponema pallidum (TP) subsp. pertenue (TPE) is present in four different monkey species. In order to gain information on the diversity and epidemiological spread of the infection in Tanzanian nonhuman primates (NHP), we identified two suitable candidate genes for multi-locus sequence typing (MLST). We demonstrate the functionality of the MLST system in invasively and non-invasively collected samples. While we were not able to demonstrate frequent interspecies transmission of TPE in Tanzanian monkeys, our results show a clustering of TPE strains according to geography and not host species, which is suggestive for rare transmission events between different NHP species. In addition to the geographic stability, we describe the relative temporal stability of the strains infecting NHPs and identified multi-strain infection. Differences between TPE strains of NHP and human origin are highlighted. Our results show that antibiotic resistance does not occur in Tanzanian TPE strains of NHP origin.
format	article
author	Idrissa S. Chuma Christian Roos Anagaw Atickem Torsten Bohm D. Anthony Collins Linda Grillová Luisa K. Hallmaier-Wacker Rudovick R. Kazwala Julius D. Keyyu Simone Lüert Ulrich Maloueki Jan Oppelt Klára J. Petrželková Alexander Piel Fiona A. Stewart David Šmajs Sascha Knauf
author_facet	Idrissa S. Chuma Christian Roos Anagaw Atickem Torsten Bohm D. Anthony Collins Linda Grillová Luisa K. Hallmaier-Wacker Rudovick R. Kazwala Julius D. Keyyu Simone Lüert Ulrich Maloueki Jan Oppelt Klára J. Petrželková Alexander Piel Fiona A. Stewart David Šmajs Sascha Knauf
author_sort	Idrissa S. Chuma
title	Strain diversity of Treponema pallidum subsp. pertenue suggests rare interspecies transmission in African nonhuman primates
title_short	Strain diversity of Treponema pallidum subsp. pertenue suggests rare interspecies transmission in African nonhuman primates
title_full	Strain diversity of Treponema pallidum subsp. pertenue suggests rare interspecies transmission in African nonhuman primates
title_fullStr	Strain diversity of Treponema pallidum subsp. pertenue suggests rare interspecies transmission in African nonhuman primates
title_full_unstemmed	Strain diversity of Treponema pallidum subsp. pertenue suggests rare interspecies transmission in African nonhuman primates
title_sort	strain diversity of treponema pallidum subsp. pertenue suggests rare interspecies transmission in african nonhuman primates
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/f8c164691259480489fa429dfbf414e4
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Strain diversity of Treponema pallidum subsp. pertenue suggests rare interspecies transmission in African nonhuman primates

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