Metalloproteinases in Endometrial Cancer—Are They Worth Measuring?

Endometrial cancer is one of the most common gynecological malignancies, yet the molecular mechanisms that lead to tumor development and progression are still not fully established. Matrix metalloproteinases (MMPs) are a group of enzymes that play an important role in carcinogenesis. They are protea...

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Autores principales:	Kaja Michalczyk, Aneta Cymbaluk-Płoska
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	metalloproteinases MMP TIMP endometrial cancer cancer Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/f8c7a91c8cef4674bf5bb1d81044bad4
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id	oai:doaj.org-article:f8c7a91c8cef4674bf5bb1d81044bad4
record_format	dspace
spelling	oai:doaj.org-article:f8c7a91c8cef4674bf5bb1d81044bad42021-11-25T17:56:58ZMetalloproteinases in Endometrial Cancer—Are They Worth Measuring?10.3390/ijms2222124721422-00671661-6596https://doaj.org/article/f8c7a91c8cef4674bf5bb1d81044bad42021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12472https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Endometrial cancer is one of the most common gynecological malignancies, yet the molecular mechanisms that lead to tumor development and progression are still not fully established. Matrix metalloproteinases (MMPs) are a group of enzymes that play an important role in carcinogenesis. They are proteases involved in the degradation of the extracellular matrix (ECM) that surrounds the tumor and the affected tissue allows cell detachment from the primary tumor causing local invasion and metastasis formation. Recent investigations demonstrate significantly increased metalloproteinase and metalloproteinase inhibitor levels in patients with endometrial cancer compared to those with normal endometrium. In this review, we aim to show their clinical significance and possible use in the diagnosis and treatment of patients with endometrial cancer. We have critically summarized and reviewed the research on the role of MMPs in endometrial cancer.Kaja MichalczykAneta Cymbaluk-PłoskaMDPI AGarticlemetalloproteinasesMMPTIMPendometrial cancercancerBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12472, p 12472 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	metalloproteinases MMP TIMP endometrial cancer cancer Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	metalloproteinases MMP TIMP endometrial cancer cancer Biology (General) QH301-705.5 Chemistry QD1-999 Kaja Michalczyk Aneta Cymbaluk-Płoska Metalloproteinases in Endometrial Cancer—Are They Worth Measuring?
description	Endometrial cancer is one of the most common gynecological malignancies, yet the molecular mechanisms that lead to tumor development and progression are still not fully established. Matrix metalloproteinases (MMPs) are a group of enzymes that play an important role in carcinogenesis. They are proteases involved in the degradation of the extracellular matrix (ECM) that surrounds the tumor and the affected tissue allows cell detachment from the primary tumor causing local invasion and metastasis formation. Recent investigations demonstrate significantly increased metalloproteinase and metalloproteinase inhibitor levels in patients with endometrial cancer compared to those with normal endometrium. In this review, we aim to show their clinical significance and possible use in the diagnosis and treatment of patients with endometrial cancer. We have critically summarized and reviewed the research on the role of MMPs in endometrial cancer.
format	article
author	Kaja Michalczyk Aneta Cymbaluk-Płoska
author_facet	Kaja Michalczyk Aneta Cymbaluk-Płoska
author_sort	Kaja Michalczyk
title	Metalloproteinases in Endometrial Cancer—Are They Worth Measuring?
title_short	Metalloproteinases in Endometrial Cancer—Are They Worth Measuring?
title_full	Metalloproteinases in Endometrial Cancer—Are They Worth Measuring?
title_fullStr	Metalloproteinases in Endometrial Cancer—Are They Worth Measuring?
title_full_unstemmed	Metalloproteinases in Endometrial Cancer—Are They Worth Measuring?
title_sort	metalloproteinases in endometrial cancer—are they worth measuring?
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/f8c7a91c8cef4674bf5bb1d81044bad4
work_keys_str_mv	AT kajamichalczyk metalloproteinasesinendometrialcanceraretheyworthmeasuring AT anetacymbalukpłoska metalloproteinasesinendometrialcanceraretheyworthmeasuring
_version_	1718411839990136832

Metalloproteinases in Endometrial Cancer—Are They Worth Measuring?

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