The influence of non-breathing-related sleep fragmentation on cognitive function in patients with cerebral small vessel disease
Jihui Wang,1,* Xiaodong Chen,2,* Jinchi Liao,2 Li Zhou,3 Siyuan Liao,2 Yilong Shan,2 Zhengqi Lu,2 Jiong Tao1 1Department of Psychiatry, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510630, People’s Republic of China; 2Department of Neurology, The Third Affiliated Hosp...
Guardado en:
| Autores principales: | , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Dove Medical Press
2019
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/f8c7f23286864ef3a85a3a755cfcfeea |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:f8c7f23286864ef3a85a3a755cfcfeea |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:f8c7f23286864ef3a85a3a755cfcfeea2021-12-02T03:12:19ZThe influence of non-breathing-related sleep fragmentation on cognitive function in patients with cerebral small vessel disease1178-2021https://doaj.org/article/f8c7f23286864ef3a85a3a755cfcfeea2019-04-01T00:00:00Zhttps://www.dovepress.com/the-influence-of-non-breathing-related-sleep-fragmentation-on-cognitiv-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Jihui Wang,1,* Xiaodong Chen,2,* Jinchi Liao,2 Li Zhou,3 Siyuan Liao,2 Yilong Shan,2 Zhengqi Lu,2 Jiong Tao1 1Department of Psychiatry, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510630, People’s Republic of China; 2Department of Neurology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510630, People’s Republic of China; 3Department of Rehabilitative Medicine, The First Affiliated Hospital of Clinical Medicine of Guangdong Pharmaceutical University, Guangzhou, 510080, People’s Republic of China *These authors contributed equally to this work Background: Cognitive impairment in patients with cerebral small vessel disease (CSVD) is common, but the pathogenic mechanism is not well understood. The situation of non-breathing-related sleep fragmentation in CSVD patients and its influence on cognitive impairment is not clear. The aim of this study was to investigate the influence of non-breathing-related sleep fragmentation on cognitive function in patients with CSVD.Methods: A group of 89 CSVD patients without breathing-related sleep disorders in the Department of Neurology, Third Affiliated Hospital of Sun Yat-sen University was enrolled. The patients underwent magnetic resonance scan, polysomnography, cognitive function evaluation using Montreal Cognitive Assessment scale (MoCA), and Mini-Mental State Examination. The patients were assigned to study group (arousal index [ArI] ≥26.8/hour) or control group (ArI <26.8/hour) based on the average level of ArI (mean =26.8, SD =7.5) at night, and the cognitive function of the patients in the two groups was analyzed.Results: The total MoCA score, the subscale scores of visuospatial ability and delayed recall in the study group were significantly lower than that in the control group (P<0.05). The cognitive impairment measured by MoCA was positively related to ArI level and %N-3 sleep according to the results of logistic regression (P<0.05).Conclusion: Non-breathing-related sleep fragmentation is associated with cognitive impairment in CSVD patients, especially executive function and delayed recall ability. Keywords: cerebrovascular disorders, sleep, fragmentation, cognition, polysomnographyWang JChen XLiao JZhou LLiao SShan YLu ZTao JDove Medical Pressarticlecerebral small vessel diseasesleep fragmentationcognitive functionpolysomnographyNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 15, Pp 1009-1014 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
cerebral small vessel disease sleep fragmentation cognitive function polysomnography Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
| spellingShingle |
cerebral small vessel disease sleep fragmentation cognitive function polysomnography Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Wang J Chen X Liao J Zhou L Liao S Shan Y Lu Z Tao J The influence of non-breathing-related sleep fragmentation on cognitive function in patients with cerebral small vessel disease |
| description |
Jihui Wang,1,* Xiaodong Chen,2,* Jinchi Liao,2 Li Zhou,3 Siyuan Liao,2 Yilong Shan,2 Zhengqi Lu,2 Jiong Tao1 1Department of Psychiatry, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510630, People’s Republic of China; 2Department of Neurology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510630, People’s Republic of China; 3Department of Rehabilitative Medicine, The First Affiliated Hospital of Clinical Medicine of Guangdong Pharmaceutical University, Guangzhou, 510080, People’s Republic of China *These authors contributed equally to this work Background: Cognitive impairment in patients with cerebral small vessel disease (CSVD) is common, but the pathogenic mechanism is not well understood. The situation of non-breathing-related sleep fragmentation in CSVD patients and its influence on cognitive impairment is not clear. The aim of this study was to investigate the influence of non-breathing-related sleep fragmentation on cognitive function in patients with CSVD.Methods: A group of 89 CSVD patients without breathing-related sleep disorders in the Department of Neurology, Third Affiliated Hospital of Sun Yat-sen University was enrolled. The patients underwent magnetic resonance scan, polysomnography, cognitive function evaluation using Montreal Cognitive Assessment scale (MoCA), and Mini-Mental State Examination. The patients were assigned to study group (arousal index [ArI] ≥26.8/hour) or control group (ArI <26.8/hour) based on the average level of ArI (mean =26.8, SD =7.5) at night, and the cognitive function of the patients in the two groups was analyzed.Results: The total MoCA score, the subscale scores of visuospatial ability and delayed recall in the study group were significantly lower than that in the control group (P<0.05). The cognitive impairment measured by MoCA was positively related to ArI level and %N-3 sleep according to the results of logistic regression (P<0.05).Conclusion: Non-breathing-related sleep fragmentation is associated with cognitive impairment in CSVD patients, especially executive function and delayed recall ability. Keywords: cerebrovascular disorders, sleep, fragmentation, cognition, polysomnography |
| format |
article |
| author |
Wang J Chen X Liao J Zhou L Liao S Shan Y Lu Z Tao J |
| author_facet |
Wang J Chen X Liao J Zhou L Liao S Shan Y Lu Z Tao J |
| author_sort |
Wang J |
| title |
The influence of non-breathing-related sleep fragmentation on cognitive function in patients with cerebral small vessel disease |
| title_short |
The influence of non-breathing-related sleep fragmentation on cognitive function in patients with cerebral small vessel disease |
| title_full |
The influence of non-breathing-related sleep fragmentation on cognitive function in patients with cerebral small vessel disease |
| title_fullStr |
The influence of non-breathing-related sleep fragmentation on cognitive function in patients with cerebral small vessel disease |
| title_full_unstemmed |
The influence of non-breathing-related sleep fragmentation on cognitive function in patients with cerebral small vessel disease |
| title_sort |
influence of non-breathing-related sleep fragmentation on cognitive function in patients with cerebral small vessel disease |
| publisher |
Dove Medical Press |
| publishDate |
2019 |
| url |
https://doaj.org/article/f8c7f23286864ef3a85a3a755cfcfeea |
| work_keys_str_mv |
AT wangj theinfluenceofnonbreathingrelatedsleepfragmentationoncognitivefunctioninpatientswithcerebralsmallvesseldisease AT chenx theinfluenceofnonbreathingrelatedsleepfragmentationoncognitivefunctioninpatientswithcerebralsmallvesseldisease AT liaoj theinfluenceofnonbreathingrelatedsleepfragmentationoncognitivefunctioninpatientswithcerebralsmallvesseldisease AT zhoul theinfluenceofnonbreathingrelatedsleepfragmentationoncognitivefunctioninpatientswithcerebralsmallvesseldisease AT liaos theinfluenceofnonbreathingrelatedsleepfragmentationoncognitivefunctioninpatientswithcerebralsmallvesseldisease AT shany theinfluenceofnonbreathingrelatedsleepfragmentationoncognitivefunctioninpatientswithcerebralsmallvesseldisease AT luz theinfluenceofnonbreathingrelatedsleepfragmentationoncognitivefunctioninpatientswithcerebralsmallvesseldisease AT taoj theinfluenceofnonbreathingrelatedsleepfragmentationoncognitivefunctioninpatientswithcerebralsmallvesseldisease AT wangj influenceofnonbreathingrelatedsleepfragmentationoncognitivefunctioninpatientswithcerebralsmallvesseldisease AT chenx influenceofnonbreathingrelatedsleepfragmentationoncognitivefunctioninpatientswithcerebralsmallvesseldisease AT liaoj influenceofnonbreathingrelatedsleepfragmentationoncognitivefunctioninpatientswithcerebralsmallvesseldisease AT zhoul influenceofnonbreathingrelatedsleepfragmentationoncognitivefunctioninpatientswithcerebralsmallvesseldisease AT liaos influenceofnonbreathingrelatedsleepfragmentationoncognitivefunctioninpatientswithcerebralsmallvesseldisease AT shany influenceofnonbreathingrelatedsleepfragmentationoncognitivefunctioninpatientswithcerebralsmallvesseldisease AT luz influenceofnonbreathingrelatedsleepfragmentationoncognitivefunctioninpatientswithcerebralsmallvesseldisease AT taoj influenceofnonbreathingrelatedsleepfragmentationoncognitivefunctioninpatientswithcerebralsmallvesseldisease |
| _version_ |
1718401897280307200 |