New Antibody Weapons against an Old Foe

ABSTRACT Antibodies have been used in a diagnostic capacity for many diseases and for identifying serotypes within single species of pathogens, notably between the multiple capsular polysaccharide serotypes of Streptococcus pneumoniae. For many years, the functions of antibodies in infection were t...

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Autor principal:	Jorge L. Benach
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2011
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/f8cc4a28785e4c9495c41e69161f84e1
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spelling	oai:doaj.org-article:f8cc4a28785e4c9495c41e69161f84e12021-11-15T15:38:58ZNew Antibody Weapons against an Old Foe10.1128/mBio.00227-112150-7511https://doaj.org/article/f8cc4a28785e4c9495c41e69161f84e12011-11-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00227-11https://doaj.org/toc/2150-7511ABSTRACT Antibodies have been used in a diagnostic capacity for many diseases and for identifying serotypes within single species of pathogens, notably between the multiple capsular polysaccharide serotypes of Streptococcus pneumoniae. For many years, the functions of antibodies in infection were thought to be limited to the opsonization of microorganisms followed by phagocytosis and to the fixing of complement. The thought that antibodies could have other functions has emerged only recently. The study by Yano and coworkers from the laboratory of Liise-anne Pirofski published in mBio [M. Yano, S. Gohil, J. R. Coleman, C. Manix, and L.-A. Pirofski, mBio 2(5):e00176-11, 2011] identifies one mechanism whereby nonopsonic antibodies enhance the transformation competence of two S. pneumoniae serotypes, which leads to an increase in genetic exchange and bacterial variability with a resulting population reduction through fratricide. These new and revealing antibody functions will add another chapter to the burgeoning story of the diversity and versatility of the immune response to bacteria.Jorge L. BenachAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 2, Iss 5 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Jorge L. Benach New Antibody Weapons against an Old Foe
description	ABSTRACT Antibodies have been used in a diagnostic capacity for many diseases and for identifying serotypes within single species of pathogens, notably between the multiple capsular polysaccharide serotypes of Streptococcus pneumoniae. For many years, the functions of antibodies in infection were thought to be limited to the opsonization of microorganisms followed by phagocytosis and to the fixing of complement. The thought that antibodies could have other functions has emerged only recently. The study by Yano and coworkers from the laboratory of Liise-anne Pirofski published in mBio [M. Yano, S. Gohil, J. R. Coleman, C. Manix, and L.-A. Pirofski, mBio 2(5):e00176-11, 2011] identifies one mechanism whereby nonopsonic antibodies enhance the transformation competence of two S. pneumoniae serotypes, which leads to an increase in genetic exchange and bacterial variability with a resulting population reduction through fratricide. These new and revealing antibody functions will add another chapter to the burgeoning story of the diversity and versatility of the immune response to bacteria.
format	article
author	Jorge L. Benach
author_facet	Jorge L. Benach
author_sort	Jorge L. Benach
title	New Antibody Weapons against an Old Foe
title_short	New Antibody Weapons against an Old Foe
title_full	New Antibody Weapons against an Old Foe
title_fullStr	New Antibody Weapons against an Old Foe
title_full_unstemmed	New Antibody Weapons against an Old Foe
title_sort	new antibody weapons against an old foe
publisher	American Society for Microbiology
publishDate	2011
url	https://doaj.org/article/f8cc4a28785e4c9495c41e69161f84e1
work_keys_str_mv	AT jorgelbenach newantibodyweaponsagainstanoldfoe
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New Antibody Weapons against an Old Foe

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