Treatment of patients with comorbid depression and diabetes with metformin and milnacipran
Peter HofmannUniversity Clinic of Psychiatry, Graz Medical University, Graz, AustriaAbstract: Depression is twice as frequent in patients with diabetes as in the general ­population, and has a negative impact on self-care, adherence to treatment, and the general prognosis of diabetes. Th...
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Dove Medical Press
2010
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oai:doaj.org-article:f8cea47e4e3a44ea818d1f29d00ac9b52021-12-02T03:59:36ZTreatment of patients with comorbid depression and diabetes with metformin and milnacipran1176-63281178-2021https://doaj.org/article/f8cea47e4e3a44ea818d1f29d00ac9b52010-08-01T00:00:00Zhttp://www.dovepress.com/treatment-of-patients-with-comorbid-depression-and-diabetes-with-metfo-a5110https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Peter HofmannUniversity Clinic of Psychiatry, Graz Medical University, Graz, AustriaAbstract: Depression is twice as frequent in patients with diabetes as in the general ­population, and has a negative impact on self-care, adherence to treatment, and the general prognosis of diabetes. This underscores the importance of screening all diabetic patients for depression and, if necessary, treating it with an effective antidepressant drug in parallel with standard diabetes ­treatment. In a recent study, a simple two-question screening tool was used to screen diabetic patients for comorbid depression. The effects of the serotonin and norepinephrine reuptake inhibitor antidepressant, milnacipran, on metabolic parameters and depressive ­symptoms in 64 diabetic patients with comorbid depression detected by this screen were ­studied. Patients received ­milnacipran for 6 months, in addition to standard diabetes treatment with metformin. At the end of the study, 72% of patients had responded to antidepressant treatment (≥50% reduction of baseline Beck Depression Score). The proportion of patients with <8% glycosylated hemoglobin HbA1c (a common indication in diabetes of the need for intensive therapeutic intervention) had decreased significantly from 46.6% at baseline to 6.9%. HbA1c, fasting blood glucose, body mass index, total and low-density lipoprotein cholesterol, and serum triglyceride levels were all significantly decreased in patients with an antidepressant response, but not in patients whose depressive symptoms had not responded to milnacipran.Keywords: depression, diabetes, milnacipran, serotonin, norepinephrine, reuptake inhibitors Peter HofmannDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2010, Iss Supplement 1, Pp 9-15 (2010) |
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Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
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Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Peter Hofmann Treatment of patients with comorbid depression and diabetes with metformin and milnacipran |
| description |
Peter HofmannUniversity Clinic of Psychiatry, Graz Medical University, Graz, AustriaAbstract: Depression is twice as frequent in patients with diabetes as in the general ­population, and has a negative impact on self-care, adherence to treatment, and the general prognosis of diabetes. This underscores the importance of screening all diabetic patients for depression and, if necessary, treating it with an effective antidepressant drug in parallel with standard diabetes ­treatment. In a recent study, a simple two-question screening tool was used to screen diabetic patients for comorbid depression. The effects of the serotonin and norepinephrine reuptake inhibitor antidepressant, milnacipran, on metabolic parameters and depressive ­symptoms in 64 diabetic patients with comorbid depression detected by this screen were ­studied. Patients received ­milnacipran for 6 months, in addition to standard diabetes treatment with metformin. At the end of the study, 72% of patients had responded to antidepressant treatment (≥50% reduction of baseline Beck Depression Score). The proportion of patients with <8% glycosylated hemoglobin HbA1c (a common indication in diabetes of the need for intensive therapeutic intervention) had decreased significantly from 46.6% at baseline to 6.9%. HbA1c, fasting blood glucose, body mass index, total and low-density lipoprotein cholesterol, and serum triglyceride levels were all significantly decreased in patients with an antidepressant response, but not in patients whose depressive symptoms had not responded to milnacipran.Keywords: depression, diabetes, milnacipran, serotonin, norepinephrine, reuptake inhibitors |
| format |
article |
| author |
Peter Hofmann |
| author_facet |
Peter Hofmann |
| author_sort |
Peter Hofmann |
| title |
Treatment of patients with comorbid depression and diabetes with metformin and milnacipran |
| title_short |
Treatment of patients with comorbid depression and diabetes with metformin and milnacipran |
| title_full |
Treatment of patients with comorbid depression and diabetes with metformin and milnacipran |
| title_fullStr |
Treatment of patients with comorbid depression and diabetes with metformin and milnacipran |
| title_full_unstemmed |
Treatment of patients with comorbid depression and diabetes with metformin and milnacipran |
| title_sort |
treatment of patients with comorbid depression and diabetes with metformin and milnacipran |
| publisher |
Dove Medical Press |
| publishDate |
2010 |
| url |
https://doaj.org/article/f8cea47e4e3a44ea818d1f29d00ac9b5 |
| work_keys_str_mv |
AT peterhofmann treatmentofpatientswithcomorbiddepressionanddiabeteswithmetforminandmilnacipran |
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