Transcorneal electrical stimulation increases chorioretinal blood flow in normal human subjects

Takuji Kurimoto1, Shinichirou Oono1, Hidehiro Oku2, Yuichi Tagami1, Ryousuke Kashimoto1, Masashi Takata1, Norio Okamoto1, Tsunehiko Ikeda2, Osamu Mimura11Department of Ophthalmology, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan; 2Department of Ophthalmology, Osaka Medical College, Takatsuki,...

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Autores principales:	Takuji Kurimoto, Shinichirou Oono, Hidehiro Oku, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/f8d3d6f87d534130b56313a97155334b
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spelling	oai:doaj.org-article:f8d3d6f87d534130b56313a97155334b2021-12-02T06:27:39ZTranscorneal electrical stimulation increases chorioretinal blood flow in normal human subjects1177-54671177-5483https://doaj.org/article/f8d3d6f87d534130b56313a97155334b2010-12-01T00:00:00Zhttp://www.dovepress.com/transcorneal-electrical-stimulation-increases-chorioretinal-blood-flow-a5828https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Takuji Kurimoto1, Shinichirou Oono1, Hidehiro Oku2, Yuichi Tagami1, Ryousuke Kashimoto1, Masashi Takata1, Norio Okamoto1, Tsunehiko Ikeda2, Osamu Mimura11Department of Ophthalmology, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan; 2Department of Ophthalmology, Osaka Medical College, Takatsuki, Osaka, Japan Purpose: The aim of this article is to investigate the effect of transcorneal electrical stimulation (TES) on chorioretinal blood flow in healthy human subjects.Methods: The chorioretinal blood flow of 10 healthy subjects was measured before and after TES by laser speckle flowgraphy and expressed as the square blur rate (SBR). The chorioretinal blood flow was determined before and immediately after TES and 0.5, 1, 1.5, 2, 2.5, 3, 24, and 40 h after TES in three different areas: the margin of the optic disc, a point located midway between the optic disc and macula, and the macula area. The SBR of the stimulated eye is expressed relative to the value of the fellow eye. The mean standardized blur ratio was calculated as the ratio of the standardized SBR to the baseline SBR. The changes of intraocular pressure (IOP), blood pressure (BP), and pulse rate (PR) were determined after each measurement of the SBR. The ocular perfusion pressure (OPP) was calculated from BP and IOP.Results: The mean standardized blur ratio at the optic disc did not change significantly throughout the course of the experiment. However, the mean standardized blur ratio midway between the optic disc and macula and at the macula area were significantly higher after TES than that after sham stimulation at 3 and 24 h (P &lt; 0.05, P &lt; 0.01, respectively). At all times, the mean BP, PR, IOP, and OPP were not significantly different from the prestimulation values.Conclusions: TES increases the chorioretinal blood flow in normal subjects with minimal effects on the systemic blood circulation and the IOP. The increase in chorioretinal blood flow may be one of the beneficial effects that TES has on ischemic retinal diseases.Keywords: transcorneal electrical stimulation, chorioretinal blood flow, laser speckle flowgraphy, healthy human subjects Takuji KurimotoShinichirou OonoHidehiro Okuet alDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2010, Iss default, Pp 1441-1446 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Takuji Kurimoto Shinichirou Oono Hidehiro Oku et al Transcorneal electrical stimulation increases chorioretinal blood flow in normal human subjects
description	Takuji Kurimoto1, Shinichirou Oono1, Hidehiro Oku2, Yuichi Tagami1, Ryousuke Kashimoto1, Masashi Takata1, Norio Okamoto1, Tsunehiko Ikeda2, Osamu Mimura11Department of Ophthalmology, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan; 2Department of Ophthalmology, Osaka Medical College, Takatsuki, Osaka, Japan Purpose: The aim of this article is to investigate the effect of transcorneal electrical stimulation (TES) on chorioretinal blood flow in healthy human subjects.Methods: The chorioretinal blood flow of 10 healthy subjects was measured before and after TES by laser speckle flowgraphy and expressed as the square blur rate (SBR). The chorioretinal blood flow was determined before and immediately after TES and 0.5, 1, 1.5, 2, 2.5, 3, 24, and 40 h after TES in three different areas: the margin of the optic disc, a point located midway between the optic disc and macula, and the macula area. The SBR of the stimulated eye is expressed relative to the value of the fellow eye. The mean standardized blur ratio was calculated as the ratio of the standardized SBR to the baseline SBR. The changes of intraocular pressure (IOP), blood pressure (BP), and pulse rate (PR) were determined after each measurement of the SBR. The ocular perfusion pressure (OPP) was calculated from BP and IOP.Results: The mean standardized blur ratio at the optic disc did not change significantly throughout the course of the experiment. However, the mean standardized blur ratio midway between the optic disc and macula and at the macula area were significantly higher after TES than that after sham stimulation at 3 and 24 h (P &lt; 0.05, P &lt; 0.01, respectively). At all times, the mean BP, PR, IOP, and OPP were not significantly different from the prestimulation values.Conclusions: TES increases the chorioretinal blood flow in normal subjects with minimal effects on the systemic blood circulation and the IOP. The increase in chorioretinal blood flow may be one of the beneficial effects that TES has on ischemic retinal diseases.Keywords: transcorneal electrical stimulation, chorioretinal blood flow, laser speckle flowgraphy, healthy human subjects
format	article
author	Takuji Kurimoto Shinichirou Oono Hidehiro Oku et al
author_facet	Takuji Kurimoto Shinichirou Oono Hidehiro Oku et al
author_sort	Takuji Kurimoto
title	Transcorneal electrical stimulation increases chorioretinal blood flow in normal human subjects
title_short	Transcorneal electrical stimulation increases chorioretinal blood flow in normal human subjects
title_full	Transcorneal electrical stimulation increases chorioretinal blood flow in normal human subjects
title_fullStr	Transcorneal electrical stimulation increases chorioretinal blood flow in normal human subjects
title_full_unstemmed	Transcorneal electrical stimulation increases chorioretinal blood flow in normal human subjects
title_sort	transcorneal electrical stimulation increases chorioretinal blood flow in normal human subjects
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/f8d3d6f87d534130b56313a97155334b
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Transcorneal electrical stimulation increases chorioretinal blood flow in normal human subjects

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